2021Äê1ÔÂ14ÈÕ£¬ngµç×ÓÓÎÏ·Á¥ÊôµÚÒ»Ò½ÔºÉñ¾Íâ¿ÆÕÅåó½ÌÊÚÍŶÓÑо¿Ð§¹û¡°A novel protein encoded by circular SMO RNA is essential for hedgehog signaling activation and glioblastoma tumorigenicity¡±ÔÚÏß½ÒÏþÓÚ¹ú¼Ê×ÅÃûѧÊõÆÚ¿¯Genome Biology£¨IF=10.806£¬ JCRÒ»Çø£©£¬Á¥ÊôµÚһҽԺΪµÚÒ»×÷ÕߺÍΨһͨѶ×÷Õßµ¥Î» ¡£¡£µÚÒ»×÷ÕßΪÁ¥ÊôµÚÒ»Ò½ÔºÉñ¾Íâ¿Æ²©Ê¿Ñо¿ÉúÎâÐò¼Î¡¢¡¢¡¢ËïÒÝÏɼÍÄîÒ½ÔºÉñ¾ÄÚ¿ÆФËÌ»ª½ÌÊÚ¡¢¡¢¡¢Á¥ÊôµÚÒ»Ò½Ôº¿ÆÑÐÖúÀíÕÅïÀ× ¡£¡£Î¨Ò»Í¨Ñ¶×÷ÕßΪÁ¥ÊôµÚÒ»Ò½ÔºÉñ¾Íâ¿ÆÕÅåó½ÌÊÚ ¡£¡£¸ÃÎÄÕÂÒÀÍÐÓÚÁ¥ÊôµÚÒ»Ò½Ôº¾«×¼Ò½Ñ§Ñо¿ÔºÊµÑéƽ̨Íê³É ¡£¡£
HedgehogÐźÅͨ·ÊÇÕý³£·¢ÓýÀú³ÌÖеıز»¿ÉÉٵķÖ×Óͨ·£¬¿ÉÊdzÉÈËÖÐHedgehogÐźÅͨ·µÄ³ÖÐøÌ«¹ý¼¤»îÈ´µ¼Ö¶àÖÖÖ×ÁöµÄ±¬·¢Ï£Íû£¬°üÀ¨½ºÖÊÁö ¡£¡£Hedgehogͨ·ÔÚ¾²Ï¢×´Ì¬Ï£¬SMO³ÖÐøÊܵ½PTCHµÄÒÖÖÆ£»£»µ±HHÅäÌåÁ¬ÏµPTCHʱ£¬SMOÊܵ½µÄÒÖÖƱ»É¨³ý£¬½øÒ»²½¼¤»îÏÂÓÎת¼Òò×ÓGli£¬µ÷¿Ø°Ð»ùÒò±í´ï ¡£¡£µ¨¹Ì´¼µÄÁ¬ÏµÓëÐÞÊζÔSMOµÄ¼¤»îÊDZØÐ裬¿ÉÊǵ¨¹Ì´¼µ÷¿ØSMO¼¤»îµÄÏêϸ»úÖÆÈÔ²»ÇåÎú ¡£¡£
ͼ£º£ºÎÄÕ·¢Ã÷×ܽá
ΪÁ˽øÒ»²½Ñо¿ÕâÌõͨ·£¬ÕÅåó½ÌÊÚÍŶÓͨ¹ý12¶Ô½ºÖÊÁö°©ºÍ°©ÅÔÑù±¾»·×´RNA²âÐò£¬Ëø¶¨Ò»¸ö¸ßƷòµÄ¡¢¡¢¡¢ÔÚ½ºÖÊÁöÖÐÏÔÖø¸ß±í´ï¡¢¡¢¡¢ÇÒÓÉHedgehogÐźÅͨ·Ö÷Òª³ÉÔ±SMO»ùÒòËùÐγɵĻ·×´»ùÒòCirc-SMO£¬½øÒ»²½µÄÑо¿Ö¤Êµ£¬Circ-SMO±àÂëÒ»¸öȫеÄÂÑ°×£¬ÃüÃûΪSMO-193a.a. ¡£¡£SMO-193a.a.¼ÓÈëÁ˽ºÖÊÁö¸Éϸ°û×ÔÎÒ¸üк͸ÉÐÔά³Ö£¬²¢Ôö½ø½ºÖÊÁö¸Éϸ°ûµÄÌåÄÚ³ÉÁöÄÜÁ¦ ¡£¡£Í¨¹ýת¼×é²âÐòºÍ·Ö×ÓÉúÎïѧÑо¿·¢Ã÷£¬SMO-193a.a.Á¬ÏµSMOĸÂÑ°×µÄN¶Ë£¬×÷Ϊµ¨¹Ì´¼µÄ¡°°áÔ˹¤¡±£¬Í¨¹ýÔËÊ䵨¹Ì´¼ÊµÏÖ¶ÔSMOµÄ¼¤»î£¬ÇÒSMO-193a.a.ÉÏÓε÷¿Ø·Ö×ÓFUSÄܱ»shh/Gli1ת¼¼¤»î£¬´Ó¶øÐγÉShh/Gli1/FUS/SMO-193a.a.Õý·´À¡µÄ¼¤»î»·Â· ¡£¡£SMO-193a.a.ÔÚ½ºÖÊÁö»¼ÕßÖи߱í´ï²¢ÌáÐѸü²îµÄÔ¤ºó£¬¾ßÓÐ×÷ΪеĽºÖÊÁöÕï¶ÏÖÎÁưеãµÄDZÄÜ ¡£¡£
ÉÏÊöÑо¿ÊÂÇé»ñµÃ¹ú¼ÒÖصãÑз¢ÍýÏëÇàÄê¿Æѧ¼ÒÏîÄ¿¡°»·×´RNA·ÒëÂÑ°×Öʵĵ÷¿ØÀú³ÌÓëÉúÎïѧ¹¦Ð§¡±¡¢¡¢¡¢¹ú¼Ò×ÔÈ»¿Æѧ»ù½ðÓÅÒìÇàÄê»ù½ðÒÔ¼°ÃæÉÏÏîÄ¿µÈÏîÄ¿µÄ×ÊÖú ¡£¡£
ÂÛÎÄÁ´½Ó£º£ºhttps://genomebiology.biomedcentral.com/articles/10.1186/s13059-020-02250-6
µØµã:¹ãÖÝÊÐиÛÎ÷·135ºÅ Óʱà:510275
µç»°: 020-84112828
ngµç×ÓÓÎÏ·°æȨËùÓÐ COPYRIGHT?1999-2022 , SUN YAT-SEN UNIVERSITY