3ÔÂ4ÈÕ£¬£¬£¬ngµç×ÓÓÎÏ·Á¥ÊôµÚÒ»Ò½ÔºÉñ¾Íâ¿ÆÕÅåó½ÌÊÚÍŶÓÔÚ¹ú¼Ê×ÅÃûѧÊõÆÚ¿¯Nature Cell Biology½ÒÏþÌâΪ¡°Circular RNA-encoded oncogenic E-cadherin variant promotes glioblastoma tumorigenicity through activation of EGFR¨CSTAT3 signalling¡±µÄÂÛÎÄ£¬£¬£¬Õ¹ÏÖC-E-CadÊǽºÖÊÁö¸Éϸ°ûTKIÔ·¢·´¿¹µÄÔÒòÖ®Ò»£¬£¬£¬¿¹C-E-CadÖÎÁÆÓÐÍû³ÉΪ½ºÖÊĸϸ°ûÁö°ÐÏò¾«×¼ÖÎÁƵÄȫз½°¸¡£¡£
¸ÃÑо¿ÓëÃÀ¹úÎ÷±±´óѧFeinbergҽѧԺShi-Yuan Cheng½ÌÊÚÅäºÏÏàÖúÍê³É£¬£¬£¬²©Ê¿ºó¸ßÐÁÑÇ¡¢¡¢¡¢Àî·²äÞ¡¢¡¢¡¢²©Ê¿ÏÄê¿¡¢¡¢¡¢¿ÆÑÐÖúÀíÕÅïÀ×ΪÅäºÏµÚÒ»×÷Õߣ¬£¬£¬Á¥ÊôµÚһҽԺΪµÚÒ»×÷ÕߺÍ×îºóͨѶ×÷Õßµ¥Î»£¬£¬£¬ÎÄÕÂÒÀÍÐÓÚ¾«×¼Ò½Ñ§Ñо¿ÔºÊµÑéÆ½Ì¨Íê³É¡£¡£
½ºÖÊĸϸ°ûÁö£¨GBM£©ÊÇÖÐÊàÉñ¾ÏµÍ³³£¼ûµÄ¶ñÐÔÖ×ÁöÖ®Ò»¡£¡£EGFR×÷ΪÖ÷ÒªµÄÇý¶¯»ùÒòÔÚÔ¼½ü°ëÊýµÄGBMÖб£´æ×Ųî±ð³Ì¶ÈµÄÀ©ÔöºÍÍ»±ä¡£¡£GBMÖеĽºÖÊÁö¸Éϸ°û±»ÒÔΪÊÇÖ×Áö±¬·¢¡¢¡¢¡¢ÄÍÒ©ºÍ¸´·¢µÄÖ÷ÒªÔÒò¡£¡£°ÐÏòEGFRÒÔ¼°½ºÖÊÁö¸Éϸ°ûÒ»Ö±ÊǽºÖÊÁö¾«×¼ÖÎÁÆÖеÄÖ÷Òª×é³É²¿·Ö¡£¡£
ËäÈ»ÈËÃǾݴ˿ª·¢³öÁË´ó×ڵķÖ×ÓÒÖÖÆ¼ÁÈçÂç°±ËἤøÒÖÖÆ¼Á£¨TKI£©µÈ£¬£¬£¬µ«ÆäÁÙ´²ÊµÑéЧ¹ûÁîÈËʧÍû¡£¡£ÉÐÎÞÓÐÓÃÒ©ÎïµÃÒÔÓ¦ÓÃÓÚÁÙ´²¡£¡£²ûÊÍEGFRµÄ¼¤»î»úÖÆÊÇGBM¾«×¼ÖÎÁÆØ½´ý½â¾öµÄÎÊÌâÖ®Ò»¡£¡£
¿ËÈÕ£¬£¬£¬ÕÅåó½ÌÊÚÍŶÓ̫ͨ¹ýÎö½ºÖÊĸϸ°ûÁöÑù±¾ºÍÅä¶ÔÕý³£×éÖ¯Ñù±¾µÄ»·×´RNA²âÐò£¨Circ-RNA Seq£©ÒÔ¼°ºËÌÇÌåÓ¡¼Ç²âÐò£¨ribosome profiling£©£¬£¬£¬Ð§¹û·¢Ã÷ÔڹŰåÒâÒåÉϵÄÒÖ°©»ùÒòE-cadherin¿ÉÒÔÐγÉÒ»¸ö»·×´RNA Circ-E-Cad²¢·ÒëСÂѰ×C-E-Cad¡£¡£C-E-Cad¿ÉÒÔͨ¹ý×ÔÉøÍ¸ÒÔ¼°ÅÔÉøÍ¸µÄ·½Ê½¼¤»îEGFR/EGFRviii²¢Ôö½ø½ºÖÊÁö¸Éϸ°ûµÄ×ÔÎÒ¸üС£¡£C-E-CadÁ¬ÏµÓÚEGFR/EGFRviiiµÄCR2½á¹¹Óò£¬£¬£¬ÒýÆð¶þÕߵijÖÐøµÍÁ÷Á¿¼¤»î£¨Í¼1£©¡£¡£

ͼ1. C-E-CadÔö½ø¼äÖÊÁö¸Éϸ°û×ÔÎÒ¸üÐÂģʽͼ
ÔÚÂãÊóÔλ³ÉÁöÄ£×ÓÖУ¬£¬£¬ÕÅåó½ÌÊÚÍŶӷ¢Ã÷¿¹C-E-CadÖÎÁÆ¿ÉÒÔÏÔÖøÒÖÖÆGBMÀú³Ì£¬£¬£¬ÑÓÉìÂãÊóÉúÑÄÆÚ£¬£¬£¬ÆäÖÎÁÆÐ§¹ûÓÅÓÚ¿¹EGFRÖÎÁÆÇÒ¶þÕßÁªÓþßÓнϺõÄÐͬÖÎÁÆÐ§¹û¡£¡£
¸ÃÑо¿ÊÂÇé»ñµÃÁ˹ú¼ÒÖØµãÑз¢ÍýÏëÇàÄê¿ÆÑ§¼ÒÏîÄ¿¡°»·×´RNA·ÒëÂѰ×Öʵĵ÷¿ØÀú³ÌÓëÉúÎïѧ¹¦Ð§¡±¡¢¡¢¡¢¹ú¼Ò×ÔÈ»¿ÆÑ§»ù½ðÓÅÒìÇàÄê»ù½ðÒÔ¼°ÃæÉÏÏîÄ¿µÈÏîÄ¿µÄ×ÊÖú¡£¡£
ÂÛÎÄÁ´½Ó£º£ºhttps://doi.org/10.1038/s41556-021-00639-4