ngµç×ÓÓÎÏ·ÐÂÎÅÍøÑ¶£¨Í¨Ñ¶Ô±»Æ¾²Ó±£©Ëæ×ÅRNAÒßÃçµÄÀÖ³ÉÕë¶ÔºËËáµÄÖÎÁÆÕ½ÂÔÔ½À´Ô½Êܵ½ÖØÊÓ¡£¡£Á£Ï¸°û°ûÍâDNAÍøÊÇÒ»ÖÖÌØÊâµÄϸ°ûÍâºËËáÐźţ¬£¬£¬ÔÚ¶àÖÖÖØ´ó¼²²¡Æðµ½Ö÷Òª×÷Óᣡ£¼ÈÍù·¢Ã÷µÄDNA¸ÐÊÜÆ÷¶¼ÔÚ°ûÄÚ£¬£¬£¬Ï¸°ûÊÇÔõÑù¸ÐÖª°ûÍâDNAÐźÅ֮ǰһֱ²»ÇåÎú¡£¡£2020Ä꣬£¬£¬ngµç×ÓÓÎÏ·ËïÒÝÏɼÍÄîÒ½ÔºËζûÎÀԺʿºÍËÕÊ¿³ÉÑо¿Ô±ÍŶÓNatureÑо¿ÎÄÕÂÅжÏÊ׸ö¶¨Î»ÔÚϸ°ûÖÊĤµÄDNA¸ÐÊÜÆ÷CCDC25£¬£¬£¬²¢ÆÊÎöÆä½éµ¼ÖÐÐÔÁ£Ï¸°û°ûÍâDNAÍø´ÙÖ×Áö×ªÒÆ»úÖÆ¡£¡£
ÕâÌ×ÐźÅÍøÂçÔÚÆäËûÑ×Ö¢¼²²¡ÊÇ·ñÓÐ×÷Óã¿ËïÒÝÏɼÍÄîÒ½ÔºËÕÊ¿³ÉÍŶӺÍɽºÓƽÍŶÓÏàÖúÕ¹ÏÖÊÈËáÐÔÁ£Ï¸°û°ûÍâDNAÍøÓëÉñ¾»¥×÷¼ÓÖØÏø´Ð»úÖÆ£¬£¬£¬Ñо¿Ð§¹ûÓÚ2021Äê10ÔÂ6ÈÕÔÚ¹ú¼ÊÖøÃûÆÚ¿¯Nature Cell BiologyÔÚÏß½ÒÏþ£¬£¬£¬ÌâΪ¡°Eosinophil extracellular traps drive asthma progression through neuro-immune signals¡±¡£¡£ Nature Cell Biology½ÒÏþͬÆÚרÆÀ£¬£¬£¬³Æ¸ÃÑо¿¡°ÎªÏø´ÖÎÁÆÌṩÁËеİе㡱£¨Lu et al. provide evidence that eosinophil-derived extracellular DNA traps worsen allergic asthma, presenting a new target for treatment£©¡£¡£¸ÃÎÄÕ±»Ñ¡Îªµ±ÆÚ·âÃæÂÛÎÄ¡£¡£ËÕÊ¿³ÉÑо¿Ô±ºÍɽºÓƽ½ÌÊÚÊDZ¾ÂÛÎĵÄÅäºÏͨѶ×÷Õß¡£¡£ËζûÎÀԺʿ¸øÓèÁËÃû¹óµÄÒâ¼û¡£¡£Â½ÒÕÎĸ±Ñо¿Ô±¡¢»ÆÒ»ð¨¡¢À轡¢»Æ¾²Ó±ºÍÕÅÀö֥ΪÎÄÕµÄÅäºÏµÚÒ»×÷Õß¡£¡£
ÔÚ¹ú¼Ò×ÔÈ»¿ÆÑ§»ù½ð¡¢¹ú¼ÒÖØµãÑз¢ÍýÏëÏîÄ¿µÄÖ§³ÖÏ£¬£¬£¬ÏàÖúÍŶӷ¢Ã÷ÁË´ó´ó¶¼ÇéÐÎÏ£¬£¬£¬Ïø´·Î²¿°ûÍâDNAÍøÖ÷ҪȪԴ²»ÊÇÖÐÐÔÁ£Ï¸°û£¬£¬£¬¶øÊÇÊÈËáÐÔÁ£Ï¸°û¡£¡£¹ýÃôÔÓÕµ¼ÐØÏÙ»ùÖÊÁܰÍϸ°ûÌìÉúËØ£¨Thymic stromal lymphopoietin, TSLP£©ÉøÍ¸£¬£¬£¬TSLPÔö½øÊÈËáÐÔÁ£Ï¸°û°ûÍâDNAÍøÐγɡ£¡£ÊÈËáÐÔÁ£Ï¸°û°ûÍâDNAÍøÍ¨¹ýÉñ¾ÄÚÉøÍ¸Ï¸°ûµÄCCDC25Ôö½øÉñ¾ëÄÉøÍ¸£¬£¬£¬Éñ¾ëļÓÖØ2ÐÍÑ×Ö¢·´Ó³¡£¡£×è¶ÏCCDC25ÄÜÏÔ×ÅÒÖÖÆÉñ¾ÄÚÉøÍ¸Ï¸°ûµÄ¼¤»îºÍÏø´ÆøµÀÑ×Ö¢·´Ó³¡£¡£ÁíÍ⣬£¬£¬Ñо¿ÍŶӻ¹Ê×´ÎϵͳµØÅжÏÊÈËáÐÔÁ£Ï¸°û°ûÍâDNAÍøÁ¬ÏµµÄÂѰ×ÒòËØ£¬£¬£¬DNAÍøÉϵÄÊÈËáÐÔÁ£Ï¸°û¹ýÑõ»¯Îïø£¨eosinophil peroxidase, EPX£©·Å´óDNA-CCDC25Ðźţ¬£¬£¬½øÒ»²½Ôö½øÉñ¾ëÄÉøÍ¸ºÍ2ÐÍÑ×Ö¢·´Ó³¡£¡£ÒÑÓдó×ÚÑо¿±¨µÀ±¨µÀÖÐÐÔÁ£Ï¸°û°ûÍâDNAÍøÔÚ¶àÖÖÑ×Ö¢¼²²¡ÖÐÆðµ½Ö÷Òª×÷Ó㬣¬£¬µ«ÆäËûϸ°ûȪԴµÄ°ûÍâDNAÍøÉÙÉÙÊܵ½¹Ø×¢¡£¡£±¾Ñо¿ÏµÍ³µØÆÊÎöÁËÊÈËáÐÔÁ£Ï¸°û°ûÍâDNAÍø×é³ÉÒòËØºÍ±¬·¢×÷ÓûúÖÆ£¬£¬£¬Îª¶àÖÖÖØ´óÑ×Ö¢Ïà¹Ø¼²²¡ÖÎÁÆÌṩÁËÐÂ˼Ð÷¡£¡£
ÂÛÎÄÁ´½Ó£º£º£ºhttps://www.nature.com/articles/s41556-021-00762-2