ngµç×ÓÓÎÏ·

05

¿ÆÑÐÏ£Íû

ngµç×ÓÓÎϷҩѧԺ£¨ÉîÛÚ£©³Âºì²¨ ¡¢¡¢¡¢³Ì·¼Ñо¿ÍŶÓÔÚÃâÒßÒÖÖÆÐ°е㠷¢Ã÷ºÍÐÂÐÍÃâÒßÒÖÖÆ¼ÁÑз¢ÁìÓòÈ¡µÃϵÁÐЧ¹û

¸å¼þȪԴ£º£º£ºÒ©Ñ§Ôº£¨ÉîÛÚ£© ±à¼­£º£º£ºÖ£Áú·É ¡¢¡¢¡¢Íõ¶¬Ã· ÔĶÁÁ¿£º£º£º

ngµç×ÓÓÎÏ·ÐÂÎÅÍøÑ¶£¨Í¨Ñ¶Ô±³Âºì²¨£©Æ÷¹ÙÒÆÖ²¿ªÕ¹ÖÁ½ñ£¬£¬ÒÆÖ²Æ÷¹ÙµÄÉúÑÄ ¡¢¡¢¡¢ÊÖÊõ¼°Êõºó´¦ÀíÒÑÈÕÒæ³ÉÊ죬£¬ÊÜÕß´æ»îÂÊÓÐËùÔö¸ß£¬£¬µ«ÒÆÖ²ÇãÔþ·´Ó³ÈÔÈ»ÊÇÍþвÊÜÕߺã¾Ã´æ»îµÄÖ÷ÒªÒòËØ¡£Òò´ËÉîÈëÑо¿Æ÷¹ÙÒÆÖ²ÃâÒßÇãÔþ±¬·¢µÄϸ°ûÐźÅлúÖÆ£¬£¬ÅжÏеÄÖÎÁưе㣬£¬¶Ô¿ª·¢ÐÂÐÍÃâÒßÖÆ¼Á¾ßÓÐÖØ´óµÄÀíÂÛ¼°ÁÙ´²ÒâÒå¡£ngµç×ÓÓÎϷҩѧԺ£¨ÉîÛÚ£©µËÎıó½ÌÊÚ ¡¢¡¢¡¢³Âºì²¨ºÍ³Ì·¼¸±½ÌÊÚÍŶӽüÈýÄêÔÚ´ËÑо¿ÁìÓòÈ¡µÃÁËһϵÁÐÖ÷ҪЧ¹û¡£

Ê×ÏÈ£¬£¬ÍŶÓÊ×´ÎÌá³öTϸ°û»î»¯µÄºËÈÊЭͬ¼¤»îÐÂÀíÂÛ£¬£¬·¢Ã÷Ò»¸öºËÈʶ¨Î»ÂѰ׸´ºÏÌåNF45/90ͨ¹ýµ÷¿ØºËÈÊrDNA»ùÒòת¼ºÍºËÌÇÌå×é×°£¬£¬ÊÇTϸ°û»î»¯¾­µäÐźÅͨ·¡°calcineurin-NFAT-IL-2¡±²»¿É»òȱµÄЭͬ´Ì¼¤ÐźÅ£»£»²¢Àֳɽ«Ò»¸ö¿¹°©¡°ÀÏÒ©¡±CX5461µÄ˳Ӧ֢À©Õ¹µ½Æ÷¹ÙÒÆÖ²ÃâÒßÇãÔþÑо¿ÁìÓò£¨EMBO Mol Med, 2021 Mar 5;13(3):e12834. IF=12.1)¡£

±ðµÄ£¬£¬¸ÃÑо¿ÍŶӻ¹Ê×´Î֤ʵÁËÃâÒß¼ì²éµãϵÁзÖ×ÓÔÚÆ÷¹ÙÒÆÖ²ÇãÔþÖеÄ×÷Ó㬣¬²¢·¢Ã÷Æä¿ÉÒÔ×÷ΪÐÂÐÍÃâÒßÒÖÖÆ¼Á¿ª·¢µÄ°Ðµã¡£ÃâÒß¼ì²éµã·Ö×ÓÊÇÃâÒßϵͳÖеÄÒÖÖÆÐÔµ÷Àí·Ö×Ó£¬£¬ÆÕ±é±í´ïÔÚÃâÒßϸ°ûÉÏ£¬£¬ÁÙ´²ÉÏÖ÷Ҫͨ¹ýµ¥¿Ë¡¿¹Ìå×è¶ÏÃâÒ߸ºµ÷¿ØÐźŽø¶øÔöÇ¿Ö×ÁöÃâÒßЧ¹û¡£ÍŶÓͨ¹ýСÊóÐÄÔàÒÆÖ²Ä£×ÓºÍÁÙ´²ÉöÔàÒÆÖ²Ñù±¾ÊӲ췢Ã÷£¬£¬ÔÚÆ÷¹ÙÃâÒßÇãÔþ±¬·¢Ê±£¬£¬PD-1 ¡¢¡¢¡¢LAG3 ¡¢¡¢¡¢CD80µÈÃâÒ߸ºµ÷¿Ø·Ö×ÓÔÚTϸ°ûºÍÆäËûÃâÒßϸ°ûÖеıí´ïÁ¿ÏÔÖøÉý¸ß£¬£¬ÍŶÓÍÆ²âÊÇÃâÒßϵͳΪÁ˽¨ÉèÃâÒßÄÍÊÜ£¬£¬ÒÔ·´¿¹ÃâÒßϸ°ûµÄÌ«¹ý»î»¯¡£È»¶ø£¬£¬ÍŶӼì²â·¢Ã÷ÆäÏìÓ¦µÄÅäÌå·Ö×ӺñÈPD-L1 ¡¢¡¢¡¢CTLA-4ºÍFGL1ÔÚÌåÄÚ²¢Ã»ÓÐÏìÓ¦µÄÉý¸ß±í´ï£¬£¬Òò´ËÃâÒßÄÍÊÜÈÔÈ»ÄÑÒÔ½¨Éè¡£¿ª·¢ÃâÒß¼ì²éµã·Ö×Ó¼¤¶¯¼Á£¨Ð¡·Ö×ÓÒ©Îï»òµ¥¿¹£©ÄѶȴ󣬣¬µ½ÏÖÔÚΪֹ»¹Ã»ÓÐÉÏÊÐÒ©Îï¡£ÓÉÓÚϸ°ûĤ¿ÉÒԺܺõıí´ïÖØ´ó½á¹¹Ä¤ÂѰ×£¬£¬Îª³ÊµÝÃâÒß¼ì²éµãÅäÌå·Ö×Ó ¡¢¡¢¡¢ÔöÇ¿ÃâÒ߸ºµ÷¿Ø£¬£¬ÖØÐÞÃâÒßÄÍÊÜÌṩÁË¿ÉÄÜ¡£¸ÃÍŶÓǰÆÚͨ¹ý»ùÒò¹¤³ÌÊÖÒÕ£¬£¬ÖƱ¸ÁË¿ÉÒԸ߱í´ïÅäÌå·Ö×ÓµÄϸ°ûĤÄÉÃ×ÄÒÅÝ£¬£¬²¢·¢Ã÷ÆäÄܹ»ÔÚÌåÄÚÍâÓÐÓõØÒÖÖÆPBMCºÍTϸ°ûµÄÔöÖµ£¬£¬ÑÓÉìÒÆÖ²Æ÷¹ÙµÄ´æ»îʱ¼ä¡££¨ACS Nano. 2020 Jul 28;14(7):7959-7969£¬£¬¸±·âÃæÎÄÕ£¬£¬IF=15.9£»£»Biomater Sci. 2021 Feb 23;9(4):1246-1255. ·âÃæÎÄÕ£¬£¬IF=6.8£»£»Theranostics. 2021 Apr 7;11(12):6033-6043. IF=11.6£©¡£

ËäȻϸ°ûĤÄÒÅÝÖÆ±¸¼òÆÓºÍȪԴ¸»×㣬£¬ÒѾ­³ÉΪÁ˺ÜÊÇÓÐÔ¶¾°µÄÉúÎïµÝËÍÖÊÁÏ£¬£¬¿ÉÊÇÒ²»¹±£´æÐí¶àÎÊÌâ¡£Ê×ÏÈ£¬£¬ÔÚÖÆ±¸Àú³ÌÖУ¬£¬Ä¤µÄ²»ÍêÕûÐÔ ¡¢¡¢¡¢ÄÚÍâĤ·­×ª£¬£¬¶¼ÓпÉÄܽµµÍÄÒÅݵÄÖÎÁÆÐ§ÂÊ¡£±ðµÄ£¬£¬Õë¶ÔһЩÃâÒßÐԵļ²²¡£¬£¬Ï¸°ûĤÄÒÅÝ¿ÉÄÜÓÉÓÚÆäÃâÒßÔ­ÐÔ¶ø¸øÃâÒß¼²²¡µÄÖÎÁÆ´øÀ´Î´ÖªµÄÇå¾²Òþ»¼£¬£¬ÒÔÊÇ¿ÎÌâ×éÒ»Ö±ÔÚѰÕÒ¸üÓÐÓà ¡¢¡¢¡¢ÉúÎïÏàÈÝÐÔ¸ü¸ßµÄÉúÎïÖÊÁÏ¡£ÍâÃÚÌåÊÇÒ»ÖÖϸ°ûÉøÍ¸µÄ×ÔȻ֬ÖÊË«²ãĤ½á¹¹£¬£¬Óëϸ°ûĤÄÒÅÝÏà±È¾ßÓиüºÃµÄÁÙ´²Ó¦ÓÃDZÁ¦¡£¿ÎÌâ×éǰÆÚʹÓÃIFN-¦ÃÓÕµ¼ÁËÐþÉ«ËØÁöϸ°ûÉøÍ¸¸ß±í´ïPD-L1µÄÍâÃÚÌ壬£¬²¢Ö¤ÊµÎúÆäÓÅÒìµÄÃâÒßÒÖÖÆÄÜÁ¦£¨´ËÑо¿Ð§¹û½ÒÏþÔÚ Journal of Extracellular Vesicles, 2020,(9):1709262. IF=25.841£©¡£

¿ËÈÕ£¬£¬¸ÃÑо¿ÍŶÓÔÚAdvanced ScienceÉϽÒÏþÁËÌâΪ¡°Engineered small extracellular vesicles as a FGL1/PD-L1 dual-targeting delivery system for alleviating immune rejection¡±µÄÑо¿ÂÛÎÄ£¨¸±·âÃæÎÄÕ£¬£¬IF=16.806£©¡£ÔÚ´ËÑо¿ÖУ¬£¬×÷ÕßÅжÏLAG-3ºÍPD-1ÊÇÁ½¸öDZÔ򵀮÷¹ÙÒÆÖ²ÃâÒßÇãÔþÖÎÁưе㣬£¬ÀÖ³ÉÖÆ±¸Á˼ä³äÖʸÉϸ°ûȪԴµÄFGL1/PD-L1Ë«°ÐµãÍâÃÚÌ壬£¬·¢Ã÷ÆäÄܹ»ÔÚСÊóÒìÌåÐÄÔàÒÆÖ²Ä£×ÓÖÐÓÐÓüõÇáÒÆÖ²ÇãÔþ£¬£¬Õ¹ÏÖÁËÓÅÒìµÄÖÎÁÆÐ§¹û¡£

Æê´ø¼ä³äÖʸÉϸ°ûÒѾ­¿ªÕ¹Á˰üÀ¨Æ÷¹ÙËðÉËÐÞ¸´ÔÚÄڵĶàÖÖÄÑÖÎÐÔ¼²²¡µÄÁÙ´²Ñо¿£¬£¬±»Ö¤ÊµÊÇÒ»ÖÖÇå¾²ÓÐÓõÄϸ°û¡£¼ä³äÖʸÉϸ°ûȪԴµÄÍâÃÚÌ壨MSC-EVs£©¾ßÓÐMSCµÄ´ó²¿·ÖÌØÕ÷£¬£¬²¢¾ßÓÐϸ°ûÃâÒßµ÷Àí¹¦Ð§£¬£¬ÏÖÒѱ»Ö¤Êµ¿ÉÒÔͨ¹ýµ÷¿ØTϸ°ûºÍBϸ°ûµÄÔöÖ³À´µ÷¿ØË³Ó¦ÐÔÃâÒß·´Ó³£¬£¬ÒÔÊÇMSC-EVs³ÉΪÖÎÁÆÃâÒßÐÔ¼²²¡¾ø¼ÑµÄÉúÎïÔØÌå¡£¿ÎÌâ×é½ÓÄÉÉúÎ﹤³ÌÊÖÒÕË¢ÐÂMSC£¬£¬»ñµÃÁËPD-L1/FGL1Ë«±í´ïµÄMSC-sEVs¡£Í¬Ê±ÌåÍâϸ°ûѧºÍÌåÄÚ¶¯ÎïÄ£×ÓʵÑéЧ¹û¾ù·¢Ã÷£¬£¬PD-L1/FGL1Ë«±í´ïMSC-sEVs¾ßÓиüÇ¿µÄ¿¹Æ÷¹ÙÒÆÖ²ÃâÒßÇãÔþ×÷Óá£×îºó»¹Ö¤Êµ£¬£¬PD-L1/FGL1Ë«±í´ïMSC-sEVsÁªºÏµÍ¼ÁÁ¿µÄFK506£¬£¬Æðµ½ÏÔÖøµÄЭͬÖÎÁÆÐ§¹û¡£Æ÷¹ÙÒÆÖ²ÇãÔþ×îºÃµÄÖÎÁÆÊÖ¶ÎÊÇÖØÐÞÃâÒßÄÍÊÜ£¬£¬¶øTregϸ°ûºÍTh1/Th2µÄ±ÈÀýÔÚÃâÒßÄÍÊÜÖØÐÞÀú³ÌÖÐÖÁ¹ØÖ÷Òª¡£Ç°ÆÚÑо¿Åú×¢FK506²»¿ÉÖØÆôTregϸ°û£¬£¬ÓÉÓÚTregϸ°ûÊǽÏÉÙÒÀÀµÓÚNFATÐźÅ;¾¶µÄ¡£µ«Ñо¿·¢Ã÷£¬£¬PD-L1/FGL1Ë«±í´ïMSC-sEVs¾ßÓÐÓÅÒìµÄÖØÐÞTregϸ°ûºÍTh1/Th2±ÈÀýµÄÄÜÁ¦£¬£¬Õâ»òÐíÊÇÁ½ÕßÁªºÏÈ¡µÃ¸üºÃÖÎÁÆÐ§¹ûµÄ·Ö×ÓÀíÂÛ»ù´¡¡£

Ê×Ò³|ngµç×ÓÓÎÏ·Öйú¼¯ÍŹٷ½ÍøÕ¾

¸ß±í´ïFGL1/PD-L1µÄ¼ä³äÖʸÉϸ°ûÍâϸ°ûÄÒÅÝÒÖÖÆÐÄÔàÒÆÖ²ÇãÔþ·´Ó³Ê¾Òâͼ

ÉÏÊöÑо¿»ñµÃÁ˹ú¼Ò×ÔÈ»¿ÆÑ§ÃæÉÏÏîÄ¿ ¡¢¡¢¡¢¹ã¶«Ê¡×ÔÈ»¿ÆÑ§»ù½ðÃæÉÏÏîÄ¿ ¡¢¡¢¡¢ÉîÛÚÊпƴ´Î¯»ù´¡Ñо¿ÖصãÏîÄ¿ºÍngµç×ÓÓÎÏ·ÖØ´óºÍ½»Ö¯ÏîÄ¿ÅàÓý»ù½ðµÈ¶à¸öÏîÄ¿µÄÖ§³Ö¡£

ÏîÄ¿×éÒѽ¨ÉèÏȽøµÄ¸ßͨÁ¿ÒÅ´«ÎÄ¿âɸѡÊÖÒÕÆ½Ì¨£¨CRISPR pooled gRNA libraries)£¬£¬ÖÂÁ¦ÓÚ×ÔÉíÃâÒߺÍÒÆÖ²ÃâÒßÁìÓòµÄлúÖÆºÍае㷢Ã÷£¬£¬²¢¿ª·¢»ùÓÚаеãµÄÐÂÐÍÃâÒßÒÖÖÆ¼ÁÒ©Îͬʱ£¬£¬ÍŶÓÒ²Àֳɽ¨ÉèÁ˹æÄ£»£»¯µÄÈËÔ´ºÍÖ²ÎïÔ´ÍâÃÚÌå´ó¹æÄ£ÖƱ¸ºÍÓ¦ÓÃÆ½Ì¨¡£

Ïà¹ØÂÛÎÄÁ´½Ó£º£º£º

1. https://doi.org/10.15252/emmm.202012834

2. https://pubs.acs.org/doi/10.1021/acsnano.9b09065

3. https://doi.org/10.1039/D0BM01798A

4. https://www.thno.org/v11p6033.htm

5. https://doi.org/10.1080/20013078.2019.1709262

6. https://doi.org/10.1002/advs.202102634

¡¾ÍøÕ¾µØÍ¼¡¿