ngµç×ÓÓÎÏ·

05

¿ÆÑÐÏ£Íû

Ðíº«Ê¦Ð¤ÓξýÍŶÓÕ¹ÏÖMETTL1½éµ¼µÄm7G¼×»ù»¯Ôö½øÀà·çʪÊàŦÑ×»¬Ä¤ÇÖÏ®µÄлúÖÆ

¸å¼þȪԴ£ºÁ¥ÊôµÚÒ»Ò½Ôº ±à¼­£ºÎâÁ¢¼á ÉóºË£ºËïÒ«±ó É󶨣º»ÆÑÞ ÔĶÁÁ¿£º

ngµç×ÓÓÎÏ·ÐÂÎÅÍøÑ¶£¨Í¨Ñ¶Ô±¿µ¾þÃù£©¿ËÈÕ£¬£¬ £¬Á¥ÊôµÚÒ»Ò½ÔºÐíº«Ê¦/ФÓξýÍŶÓÊ×´ÎÕ¹ÏÖÁ˼׻ù×ªÒÆÃ¸ÑùÂѰ×1£¨METTL1£©½éµ¼µÄmRNAÄÚ²¿N7-¼×»ùÄñÜÕ£¨m7G£©ÐÞÊÎÔÚÀà·çʪÊàŦÑ×£¨RA£©³ÉÏËάÑù»¬Ä¤Ï¸°û£¨FLSs£©Òì³£»£»£»î»¯¼°ÊàÅ¦ÆÆËðÖеÄÒªº¦×÷Óᣡ£Ïà¹ØÑо¿½ÒÏþÔÚ·çʪ²¡ÁìÓò¶¥¼¶ÆÚ¿¯¡¶·çʪ²¡Ñ§Äê¼ø¡·£¨Annals of the Rheumatic Diseases£©¡£¡£

B2B085ADA05B4ABCF932C2620D3_05713602_E9FE

Ñо¿·¢Ã÷£¬£¬ £¬RA»¼Õß»¬Ä¤×éÖ¯¼°FLSsÖÐMETTL1±í´ï¼°m7GÐÞÊÎˮƽÏÔÖøÉý¸ß£¬£¬ £¬ÇÒÓë¼²²¡»î¶¯¶È³ÊÕýÏà¹Ø¡£¡£ÇõÍMETTL1ÄÜÓÐÓÃÒÖÖÆRA FLSsÇÖÏ®ÄÜÁ¦ºÍ»ùÖʽðÊôÂѰ×ø9£¨MMP9£©µÄ±í´ï¡£¡£ÌåÄÚÑо¿Ö¤Êµ£¬£¬ £¬ÇõÍMETTL1¿ÉÏÔÖø½µµÍRA¶¯ÎïÄ£×ÓµÄÊàŦÑ×ÑÏÖØ³Ì¶È¡£¡£»£»£»úÖÆÉÏ£¬£¬ £¬METTL1ͨ¹ý´ß»¯×éÖ¯ÂѰ×øB£¨CTSB£©mRNA 5'·Ç·­ÒëÇø£¨5' UTR£©µÄÌØ¶¨Î»µã±¬·¢m7G¼×»ù»¯£¬£¬ £¬´Ó¶øÔöÇ¿CTSB mRNAµÄ·­ÒëЧÂÊ£¬£¬ £¬×îÖÕÔö½øCTSBÂѰ׵ĺϳÉÓëÉøÍ¸¡£¡£¸ÃÑо¿²»µ«ÆÊÎöÁËMETTL1-m7G-CTSBÖáÊÇÇý¶¯RA»¬Ä¤ÇÖÏ®ºÍÊàÅ¦ÆÆËðµÄÒ»¸öȫбí¹Ûת¼µ÷¿Ø»úÖÆ£¬£¬ £¬Ò²Îª¿ª·¢ÒÔMETTL1Ϊ°ÐµãµÄRA¾«×¼ÖÎÁÆÌṩÁ˼áʵµÄʵÑé»ù´¡¡£¡£

Á¥ÊôµÚÒ»Ò½Ôº·çʪÃâÒß¿ÆÐíº«Ê¦½ÌÊÚΪ×îºóͨѶ×÷Õߣ¬£¬ £¬·çʪÃâÒß¿ÆÐ¤Óξý¸±½ÌÊÚÓëÄÏ·½Ò½¿Æ´óѧÖé½­Ò½Ôº½ÓÁ¦¸Õ½ÌÊÚΪÅäºÏͨѶ×÷Õߣ¬£¬ £¬·çʪÃâÒ߿ƳÂ˼Ãñ²©Ê¿¡¢¡¢¡¢Ëïâý²©Ê¿ºÍÅí³¿¹â˶ʿΪÅäºÏµÚÒ»×÷Õß¡£¡£

ÂÛÎÄÁ´½Ó£ºhttps://ard.eular.org/article/S0003-4967(25)04415-2/abstract



¡¾ÍøÕ¾µØÍ¼¡¿