ngµç×ÓÓÎÏ·ÐÂÎÅÍøѶ£¨Í¨Ñ¶Ô±ÕÅÀö£©¿ËÈÕ£¬£¬Cell metabolismÔÓÖ¾ÔÚÏß½ÒÏþÁËÌâΪ¡°Stress triggers irritable bowel syndrome with diarrhea through a spermidine-mediated decline in type I interferon¡±µÄÑо¿Ð§¹û£¬£¬¸ÃÑо¿Îªngµç×ÓÓÎÏ·Á¥ÊôµÚÈýÒ½ÔºÉñ¾ÃâÒßÓ뿵½¡³¤ÊÙÑо¿ÖÐÐĵĽù½òÍŶÓЧ¹û£¬£¬±¨µÀÁËѹÁ¦ÓÕµ¼¸¹ÐºÐͳ¦Ò×¼¤×ÛºÏÕ÷µÄÏêϸ·Ö×Ó»úÖÆ¡£¡£
¸¹ÐºÐͳ¦Ò×¼¤×ÛºÏÕ÷£¨Irritable Bowel Syndrome with diarrhea, IBS-D£©ÊÇÒ»ÖÖÂýÐÔ¹¦Ð§ÐÔ賦µÀ¼²²¡£¬£¬»¼Õß³£ÌåÏÖ³ö½á³¦¾·ÂΡ¢¡¢¡¢ÂýÐÔ¸¹Í´¡¢¡¢¡¢¸¹Õͺ͸¹ÐºµÈÅűã¸Ä±ä¡£¡£ÏÖÔÚÒÔΪIBS-DµÄ·¢²¡»úÖÆÓëÐÄÀíÓ¦¼¤¡¢¡¢¡¢¼¡ÈâÒì³£Ëõ¶Ì¡¢¡¢¡¢Ñ×Ö¢ºÍ³¦µÀ¾úȺÔÓÂҵȶàÖÖÒòËØÓйء£¡£È»¶ø£¬£¬ÏÖÔÚÉÐȱ·¦¶ÔÕâЩÒòËØÖ®¼äÂß¼µ÷¿ØÏà¹ØÐÔµÄÖÜÈ«ÆÊÎö¡£¡£
½üÄêÀ´£¬£¬Ñо¿Åú×¢£¬£¬Ñ¹Á¦ÔÚIBS-DµÄ±¬·¢ºÍ¼Ó¾çÖÐÆðµ½ÁËÖ÷Òª×÷Óᣡ£ÆÕ±éµÄ»ùÒò×éÆÊÎöÏÔʾ£¬£¬IBS-DµÄÒÅ´«Ò׸ÐÐÔÖ÷ÒªÓëÇéÐ÷ÕÏ°Óйأ¬£¬°üÀ¨½¹ÂǺÍÒÖÓôµÈÖ¢×´¡£¡£Ñ¹Á¦¿ÉÒÔͨ¹ý¸Ä±ä³¦µÀ¼¡ÈâµÄËõ¶ÌÀ´Ó°ÏìÏû»¯ÏµÍ³µÄ¹¦Ð§£¬£¬µ¼ÖÂÅűãÏ°¹ßµÄת±ä¡£¡£È»¶ø£¬£¬ÏÖÔÚ¶ÔѹÁ¦ÓÕµ¼IBS-DµÄ»úÖÆÏàʶÈÔÈ»ÓÐÏÞ£¬£¬Ïà¹ØµÄ²¡Àí¸Ä±äºÍ׼ȷµÄÒ©Îï°ÐµãÉÐδÃ÷È·¡£¡£
ÔÚ±¾ÏîÑо¿ÖУ¬£¬Ñо¿ÍŶӷ¢Ã÷ѹÁ¦ÓÕµ¼ÁËIBS-D»¼ÕߺÍСÊóѪÇåÖлÆàÑßʵÄÌ«¹ý±¬·¢£¬£¬²¢ÇÒͨ¹ýÌåÄÚʵÑéÑéÖ¤»ÆàÑßÊ¿ÉÒÔÖ±½ÓÓÕµ¼³¦Ò×¼¤×ÛºÏÕ÷Ïà¹ØÖ¢×´µÄ±¬·¢¡£¡£Ñо¿ÍŶÓͨ¹ý¶ÔСÊóµÄ·à±ã¾ÙÐкê»ùÒò×é²âÐòÆÊÎö£¬£¬·¢Ã÷ѹÁ¦ºÍ»ÆàÑßÊ´¦ÀíÄܹ»Ö±½Ó¸Ä±äСÊ󳦵ÀÊóÈé¸Ë¾ú£¨Lactobacillus murinus£©µÄƷòºÍ´úлÌØÕ÷¡£¡£½øÒ»²½µÄÑо¿·¢Ã÷£¬£¬À©ÔöµÄÊóÈé¸Ë¾ú±¬·¢ÁË´ó×ÚµÄÑǾ«°·£¬£¬Ö±½ÓÓÕµ¼ÁËIBS-DµÄ±¬·¢¡£¡£Ö»¹ÜÑǾ«°·¾ßÓжàÖÖÐÄÀíЧӦ£¬£¬°üÀ¨×ÔÊɵ÷Àí¡¢¡¢¡¢ÎÈ̬ά³Ö¡¢¡¢¡¢Ñ×Ö¢ÒÖÖƺÍÖ¬ÖÊ´úл£¬£¬µ«ÆäÔõÑùÔö½øѹÁ¦Òý·¢µÄIBS-DµÄ²¡Àí»úÖÆÈÔ²»ÇåÎú¡£¡£
Ñо¿ÍŶÓÉîÈëµÄ»úÖÆÑо¿Åú×¢£¬£¬ÑǾ«°·¿ÉÒÔÒÖÖÆTRAF3µÄk63¶à¾Û·ºËØ»¯£¬£¬ÒÖÖƽ¬Ï¸°ûÑùÊ÷ͻ״ϸ°û£¨Plasmacytoid dendritic cell£¬£¬pDC£©ÖÐIÐÍ×ÌÈÅËØ(IFN)-¦ÁµÄ»ù´¡±í´ï¡£¡£Ò»ÐÍ×ÌÈÅËصĽµµÍÄܹ»Ö±½ÓÔö½ø½á³¦Æ½»¬¼¡Ï¸°ûµÄËõ¶Ì£¬£¬´Ó¶øµ¼ÖÂÅűãÔöÌí¡£¡£
±¾Ñо¿ÆÊÎöÁËѹÁ¦ÓÕµ¼¸¹ÐºÐͳ¦Ò×¼¤×ÛºÏÕ÷µÄÏêϸ·Ö×Ó»úÖÆ£¬£¬Õ¹ÏÖÁËÃâÒß´úлʧµ÷¡¢¡¢¡¢¾«ÉñѹÁ¦¡¢¡¢¡¢Î¢ÉúÎïȺÔÓÂҺͽ᳦ƽ»¬¼¡Ëõ¶Ì¹¦Ð§ÕÏ°Ö®¼äµÄÄÚÔÚÁªÏµ¡£¡£ÕâÒ»·¢Ã÷²»µ«Ôö½øÁËÎÒÃǶÔIBS-D²¡Àí»úÖƵÄÃ÷È·£¬£¬Ò²ÎªÎ´À´IBS-DµÄÖÎÁÆÕ½ÂÔÌṩÁËеÄÆ«Ïò¡£¡£±¾Ñо¿»ñµÃÁËÖصãÏîÄ¿¡¢¡¢¡¢ÃæÉÏÏîÄ¿ºÍÇàÄê¿Æѧ»ù½ðµÈµÄ×ÊÖú¡£¡£
ngµç×ÓÓÎÏ·Á¥ÊôµÚÈýÒ½Ôº½ù½ò½ÌÊÚ¡¢¡¢¡¢¶«ÄÏ´óѧÀîÒìæ½ÌÊÚΪ±¾ÎĵÄÅäºÏͨѶ×÷Õß¡£¡£Õã½´óѧҽѧԺÁ¥ÊôÉÛÒÝ·òÒ½ÔºÌØƸÑо¿Ô±ÕÅÀö¡¢¡¢¡¢Õã½´óѧÒѽáÒµ²©Ê¿Íõê»Àõ¡¢¡¢¡¢Õã½´óѧÕÅÑÇ·¼²©Ê¿¡¢¡¢¡¢ngµç×ÓÓÎÏ·Á¥ÊôµÚÈýÒ½ÔºÖúÀíÑо¿Ô±Ã«ÐÅ躡¢¡¢¡¢Õã½´óѧÒѽáÒµ²©Ê¿ÎâæÃæÃΪ±¾ÎĵÄÅäºÏµÚÒ»×÷Õß¡£¡£
ÂÛÎÄÁ´½Ó£º£º£ºhttps://www.cell.com/cell-metabolism/abstract/S1550-4131(24)00366-8
µØµã:¹ãÖÝÊÐиÛÎ÷·135ºÅ Óʱà:510275
µç»°: 020-84112828
ngµç×ÓÓÎÏ·°æȨËùÓÐ COPYRIGHT?1999-2022 , SUN YAT-SEN UNIVERSITY