ngµç×ÓÓÎÏ·

05

¿ÆÑÐÏ£Íû

ÖÐɽÈýÔºÈÖÀûÃñ/ºÎÁôÃñÍŶÓÌá³ö×éÖ¯ÈÚºÏË®Äý½ºÖØËܼ¹ËèËðÉË΢ÇéÐÎÎÈ̬´ÙÉñ¾­ÔÙÉúÐÞ¸´ÐÂÕ½ÂÔ

¸å¼þȪԴ£º£º£ºÁ¥ÊôµÚÈýÒ½Ôº ±à¼­£º£º£ºÌ¸Ï£¡£¡£¡¢¡¢Â¬ì½Î¬ ÉóºË£º£º£ºËïÒ«±ó ÔĶÁÁ¿£º£º£º

ngµç×ÓÓÎÏ·ÐÂÎÅÍøÑ¶£¨Í¨Ñ¶Ô±ºÎÁôÃñ£©¿ËÈÕ£¬Á¥ÊôµÚÈýÒ½ÔºÄÔ²¡ÖÐÐļ¹ÖùÍâ¿ÆÍŶÓÔÚ¹ú¼Ê×ÛºÏѧÊõÆÚ¿¯Science Advances£¨ÖпÆÔºÒ»ÇøTop£©½ÒÏþÌâΪ¡°Integrating hydrogels manipulate ECM deposition after spinal cord injury for specific neural reconnections via neuronal relays¡±µÄÑо¿ÂÛÎÄ¡£¡£¡£¡£¡£

¼¹ËèÊÇÖÐÊàÉñ¾­ÏµÍ³Ö÷Òª×é³É²¿·Ö£¬ËðÉ˺ó¼«Ò×Ôì³ÉÑÏÖØµÄÉñ¾­¹¦Ð§Õϰ­£¬¾ßÓÐÖ²ÐÂʸß¡¢¡¢éæÃüÂʸߺÍÖÎÁÆÄÑÌâµÈÌØµã£¬ÆäÐÞ¸´³ÉΪµ±½ñÌìÏÂÐÔҽѧÄÑÌâ¡£¡£¡£¡£¡£ÉúÎïÖÊÁϽüÄêÔÚ¸ÄÉÆËðÉË΢ÇéÐκÍÔö½øÉñ¾­ÔÙÉúÉÏÈ¡µÃÁîÈ˹ÄÎèµÄÏ£Íû£¬Îª¼¹ËèËðÉËÐÞ¸´´øÀ´ÐµÄÏ£Íû¡£¡£¡£¡£¡£ÎÒÔº¼¹ÖùÍâ¿ÆÍŶÓʹÓöà°Í°·½Ó֦͸Ã÷ÖÊËᣨHADA£©²¢ÁªºÏ¹¦Ð§¶ÌëÄHRR¹¹½¨ÁËÍØÆË½á¹¹¡¢¡¢ÉúÎï»îÐÔ¡¢¡¢ÉúÎïÁ¦Ñ§µÈ¶àģ̬Èںϼ¹ËèµÄ³¬·Ö×ÓË®Äý½º£¬Äܹ»¸ºÔز¢»ºÂýÊÍ·ÅÉñı»®ÑøÒò×ÓNT3Ó뿹Ñ×Ò©Îェ»ÆËØ£¨Cur£©£¬´Ó¶ø¸ÄÉÆÖáÍ»ÔÙÉú΢ÇéÐΣ¬Ôö½øÖáÍ»ÔÙÉúºÍËðÉËÁ½Í·µÄÉñ¾­Ôª´æ»î£¬²¢ÇÒ½¨ÉèÁËÌØÒìÐÔµÄÍ»´¥½á¹¹£¬ÊµÏÖÉÏÏÂÐÐÉñ¾­ÏËÎ¬ÖØÐÂÅþÁ¬£¨Í¼1£©¡£¡£¡£¡£¡£

42E972EC101865073FDB6BC8771_188D00C7_F5F7

ͼ1£º£º£ºHADA/HRR+NT3/CurË®Äý½ºÖØËÜϸ°ûÍâ»ùÖÊÖØÐÞÉÏÏÂÐÐÉñ¾­ÁªÏµ

ÔÚÕý³£×éÖ¯ÖУ¬Ï¸°ûÍâ»ùÖÊ£¨extracellular matrix£¬ECM£©ÎªÏ¸°ûµÄÉúÑļ°»î¶¯ÌṩÏàÒ˵ij¡ºÏ£¬µ«¼¹ËèËðÉ˺óECMÌ«¹ý³Á»ýÐγÉÏËάñ£º£º£ºÛ£¬³ÉΪÖáÍ»ÔÙÉúµÄÎïÀíÆÁÕÏ¡£¡£¡£¡£¡£¸ÃÍŶӷ¢Ã÷£¬HADA/HRRË®Äý½ºÄæ×ªÁ˼¹ËèËðÉ˺óÏËά»¯Àú³Ì£¬»ñµÃƽÐÐÅÅÁеĽṹָµ¼ÔÙÉúÖáÍ»Éú³¤£¬¶ø·ÇÎÞ¹æÂþÑܵÄÖÂÃÜñ£º£º£ºÛ¡£¡£¡£¡£¡£½øÒ»²½Ñо¿·¢Ã÷£¬PDGFR¦Â+ϸ°û£¨¼¹ËèËðÉ˺óÏËάñ£º£º£ºÛÖ÷ÒªÐγÉϸ°û£©ÔÚHADA/HRRË®Äý½º¸ÉÔ¤×é³ÊƽÐÐÅÅÐò·½Ê½ÏòË®Äý½ºÇ¨á㣬¶ø·ÇÎÞ¸ÉÔ¤×éµÄÎÞ¹æÇ¨áã¡£¡£¡£¡£¡£»£»ºÊÍNT3ºÍCurºóÄܹ»½øÒ»²½ÔöÇ¿ECMÖØËÜЧ¹û£¨Í¼2£©¡£¡£¡£¡£¡£ÕâÌáÐÑ£¬HADA/HRRË®Äý½ºÍ¨¹ýµ÷¿ØPDGFR¦Â+ϸ°ûÐÐÎªÖØËÜECM£¬Îª¼¹ËèËðÉ˺óÏËάñ£º£º£ºÛ¸ÉÔ¤ÌṩÁËÒ»ÖÖÁ¢ÒìÕ½ÂÔ¡£¡£¡£¡£¡£

D0F4DDB9A2EF72EA57DB732D4EB_F785F0D6_2837B

ͼ2£º£º£ºHADA/HRR+NT3/CurË®Äý½ºµ÷¿ØPDGFR¦Â+ϸ°û½þÈóÖØËÜËðÉ˽çÏßECM

Éñ¾­ÔªºÍÖáÍ»¾ßÓнṹºÍ¹¦Ð§µÄ¸ß¶ÈÒìÖÊÐÔ£¬ÖØÐÞµÄÉñ¾­½á¹¹ÐèʵÏÖ¿µ½¡¼¹ËèÖÐÌØÒìÐÔµÄÉñ¾­ÁªÏµ£¬ÕâÊǹ¦Ð§»Ö¸´µÄÒªº¦¡£¡£¡£¡£¡£

ÔÚ¸ÃÑо¿ÖУ¬HADA/HRR+NT3/CurË®Äý½ºÔö½øÁËËðÉ˽çÏßÖÐÐÄÉñ¾­ÔªµÄ´æ»î¡£¡£¡£¡£¡£ÕâЩ¼¤»îµÄÖÐÐÄÉñ¾­Ôª×÷ΪÖмÌÕ¾£¬ÓëÖÐÖ¹µÄÉÏÏÂÐÐÉñ¾­ÏËάÐγÉÁËÒìÖÊÐÔÍ»´¥½á¹¹£¬ÊµÏÖÉñ¾­ÁªÏµµÄ¡°¾«×¼¡±ÖØÐÞ£¬Ôö½øÁËÔ˶¯¡¢¡¢¸ÐÊܺͰòë×¹¦Ð§»Ö¸´¡£¡£¡£¡£¡£

Ñо¿»¹Õ¹ÏÖÁËHADA/HRR+NT3/Cur Ë®Äý½ºÔöÇ¿ÁËËðÉËÁ½Í·V2aÉñ¾­Ôª´æ»î£¬²¢Óë´«µ¼ÊøÉñ¾­ÏËά½¨ÉèÐË·ÜÐÔÍ»´¥ÁªÏµ£¨Í¼3£©£¬ÌáÐѼ¤»îÌØ¶¨ÖмÌÉñ¾­Ôª²¢Ôö½øËüÃÇÕûºÏµ½Éñ¾­ÍøÂçÖжԹ¦Ð§»Ö¸´µÄÖ÷ÒªÐÔ¡£¡£¡£¡£¡£Æù½ñ£¬¼¹ËèËðÉ˺óÉñ¾­½á¹¹ÔÙÉúÈ¡µÃÁËÁîÈ˹ÄÎèµÄÏ£Íû£¬µ«¹¦Ð§»Ö¸´È´ÔâÓöÆ¿¾±¡£¡£¡£¡£¡£¸ÃÑо¿»¹·¢Ã÷£¬Ô˶¯¹¦Ð§»Ö¸´Óë¡°ÖмÌÉñ¾­Ôª¡±ÊýÄ¿ÕýÏà¹Ø£¬ÕâΪ¼¹ËèËðÉËÐÞ¸´ÌṩÁËDZÔڵĸÉÔ¤°Ðµã¡£¡£¡£¡£¡£

3E2B87E8261BFA71A98C1A5FF15_DE8EF3E1_25C67

ͼ3£º£º£ºHADA/HRR+NT3/Cur Ë®Äý½ºÓÕµ¼ËðÉ˽çÏßÖÐÐÄÉñ¾­Ôª½¨ÉèÒìÖÊÐÔÉñ¾­ÅþÁ¬

×ÛÉÏ£¬¸ÃÑо¿ÌṩÁËÒ»ÖÖ»ùÓÚ×éÖ¯ÈÚºÏÐÔË®Äý½ºÖØËܼ¹ËèËðÉË΢ÇéÐÎÎÈ̬Ôö½øÉñ¾­ÔÙÉúÓ빦Ч»Ö¸´µÄÕ½ÂÔ£¬Ëù»ñµÃµÄЧ¹ûÔڱȸñÈ®¼¹Ëè°ëºá¶ÏËðÉËÐÞ¸´ÖлñµÃÑéÖ¤¡£¡£¡£¡£¡£Ñо¿Í¬Ê±Ò²Õ¹ÏÖÁËÌØ¶¨Éñ¾­ÔªÑÇȺÔÚÉñ¾­½á¹¹ÖØÐÞÖеÄ×÷Óã¬ÒÔ´Ë×÷Ϊ¸ÉÔ¤°Ðµã£¬ÉîÈë̽ÌÖÆäÅþÁ¬¼¹Ëè´«µ¼ÊøµÄÒªº¦»úÖÆ£¬½«Îª¹¦Ð§»Ö¸´µÄÌṩÀíÂÛÒÀ¾Ý£¬Íƶ¯¼¹ËèËðÉËÔÙÉúÐÞ¸´ÊÖÒյĿªÕ¹¡£¡£¡£¡£¡£

¹Ç¿ÆÑ§¿Æ´ø¶¯ÈËÈÖÀûÃñ½ÌÊÚ¡¢¡¢¹Ç¿ÆºÎÁôÃñÑо¿Ô±ÎªÍ¨Ñ¶×÷Õߣ¬¼¹ÖùÍâ¿ÆË¶Ê¿Ñо¿ÉúÌ·ÔÞ¡¢¡¢Ð¤Â¡ÓкÍÂí¾ýÎäΪÅäºÏµÚÒ»×÷Õß¡£¡£¡£¡£¡£¸ÃÑо¿»ñµÃÁ˹ú¼Ò×ÔÈ»¿ÆÑ§»ù½ð£¨32271417£¬32071354£¬U22A20297£©£¬¹ã¶«Ê¡¿Æ¼¼Á¢ÒìÕ½ÂÔרÏîÔÁ¸Û¿Æ¼¼Á¢ÒìÁªºÏ×ÊÖúÏîÄ¿£¨2021A0505110007£©£¬¹ã¶«Ê¡×ÔÈ»¿ÆÑ§»ù½ð-ÓÅÒìÇàÄêÏîÄ¿£¨022B1515020083£©£¬¹ãÖÝÊÐÖØµãÑз¢ÍýÏ루202206060002£¬202206060003£©µÈ»ù½ðµÄ×ÊÖú¡£¡£¡£¡£¡£

ÂÛÎÄÁ´½Ó:https://www.science.org/doi/10.1126/sciadv.ado9120

¡¾ÍøÕ¾µØÍ¼¡¿