ngµç×ÓÓÎÏ·

05

¿ÆÑÐÏ£Íû

ngµç×ÓÓÎÏ·Á¥ÊôµÚÈýÒ½ÔºÄÔ²¡ÖÐÐÄÉñ¾­ÃâÒßÍŶӹØÓÚ×ÔÉíÃâÒßÐÔÄÔÑ×ÒÅ´«»úÖÆÑо¿È¡µÃÏ£Íû

¸å¼þȪԴ£º£º£ºÁ¥ÊôµÚÈýÒ½Ôº ±à¼­£º£º£ºÂ¬ì½Î¬ ÉóºË£º£º£ºËïÒ«±ó ÔĶÁÁ¿£º£º£º

ngµç×ÓÓÎÏ·ÐÂÎÅÍøÑ¶£¨Í¨Ñ¶Ô±ÊæÑÂÇ壩¿ËÈÕ£¬£¬Á¥ÊôµÚÈýÒ½ÔºÄÔ²¡ÖÐÐÄÉñ¾­ÃâÒßÍŶÓÔÚÉñ¾­²¡Ñ§Æì½¢ÆÚ¿¯Annals of Neurology£¨ÖпÆÔºÒ»ÇøTop£¬£¬IF=11.2£©½ÒÏþÁËÌâΪ ¡°Autoimmune glial fibrillary acidic protein astrocytopathy is associated with HLA-A*3303 and HLA-DPB1*0501¡±µÄÑо¿ÂÛÎÄ¡£¡£¡£¡£¸ÃÑо¿ÓÉÁ¥ÊôµÚÈýÒ½ÔºÄÔ²¡ÖÐÐÄÉñ¾­ÃâÒßÍŶÓÁªºÏµÂ¹úBorstelÑо¿ÖÐÐļ°º£Äϸ¾Å®¶ùͯҽѧÖÐÐĵȺ£ÄÚÍâ16¼Òµ¥Î»ÅäºÏÍê³É¡£¡£¡£¡£ÄÔ²¡ÖÐÐÄÊæÑÂÇåΪÂÛÎĵÚÒ»×÷Õߣ»£»£»Á¥ÊôµÚÈýÒ½Ôº¿Í×ù½ÌÊÚ¡¢¡¢¡¢µÂ¹úBorstelÑо¿ÖÐÐÄÓàлª£¬£¬ÄÔ²¡ÖÐÐÄÇñΰΪÂÛÎÄÅäºÏͨѶ×÷Õß¡£¡£¡£¡£

×ÔÉíÃâÒßÐÔ½ºÖÊÏËάËáÐÔÂѰ×ÐÇÐνºÖÊϸ°û²¡£¡£¡£¡£¨GFAP-A£©ÊÇÒ»ÖÖÐÂÐ͵ÄÉñ¾­ÏµÍ³×ÔÉíÃâÒß²¡£¡£¡£¡£¬£¬ÁÙ´²ÌåÏÖΪÄÔĤ¡¢¡¢¡¢ÄÔʵÖÊ¡¢¡¢¡¢¼¹Ëè¡¢¡¢¡¢ÊÓÉñ¾­¡¢¡¢¡¢ÖÜΧÉñ¾­ÊÜÀÛ¡£¡£¡£¡£GFAP-AÊôÓÚÓÐÊý²¡£¡£¡£¡£¬£¬ºÃ·¢ÓÚÇà׳Ä꣬£¬ÁÙ´²ÒìÖÊÐÔÇ¿£¬£¬»úÖÆ²»ÇåÎú£¬£¬¼«Ò×ÎóÕïÇÒÔ¤ºó²î£¬£¬¸ø¼ÒÍ¥ºÍÉç»á´øÀ´¼«Öؼ縺¡£¡£¡£¡£Òò´Ë£¬£¬ÆÊÎö¸Ã²¡·¢²¡²¡ÒòÓë»úÖÆÉõΪҪº¦¡£¡£¡£¡£

±¾Ñо¿ÔÚ¹ú¼ÊÉÏÂÊÏȶÔGFAP-A¼²²¡HLA»ùÒò¾ÙÐÐÅÐ¶ÏÆÊÎö£¬£¬·¢Ã÷GFAP-A·¢²¡Ò׸ÐÐÔÏà¹ØµÄ»ùÒò£º£º£ºHLA-A*3303ºÍHLA-DBP1*0501¡£¡£¡£¡£ÁíÍ⣬£¬³ýÁ˺ͼ²²¡µÄÒ׸ÐÐÔÏà¹ØÍ⣬£¬HLA-A*3303»¹ºÍÁÙ´²Ö¸±êÏÔÖøÏà¹Ø£¬£¬ÌáÐÑÕâÒ»HLA- IÀà·Ö×Ӻͼ²²¡µÄÑÏÖØ³Ì¶ÈºÍ/»ò¶ÔÖÎÁƵķ´Ó³Ïà¹Ø¡£¡£¡£¡£

ͨ¹ý¶ÔHLA»ùÒò·ÖÐÍ·¢Ã÷£¬£¬GFAP-A¼²²¡Ò׸ÐÐÔºÍHLA-A*3303 (OR = 2.02, 95% CI = 1.32 ¨C 3.06, P = 0.00072, Padj. = 0.046) ÒÔ¼°HLA-DBP1*0501 (OR = 0.51, 95% CI = 0.36 ¨C 0.71, P = 0.000048, Padj. = 0.0062) ÏÔÖøÏà¹Ø¡£¡£¡£¡£

½øÒ»²½ÆÊÎö·¢Ã÷£¬£¬ºÍ²»Ð¯´øHLA-A*3303µÄGFAP-A»¼ÕßÏà±È£¬£¬Ð¯´øHLA-A*3303µÄGFAP-A»¼ÕßÁÙ´²Ö¸±êÒ²±£´æÏÔÖø²î±ð£¬£¬ÀýÈçסԺʱ³¤¸ü³¤£¬£¬ÑªÌÇˮƽ¸ü¸ßµÈ£¨Í¼1£©¡£¡£¡£¡£

9028AA51CC8B8D94800D3882FB1_3DC890AE_5F8F

ͼ1 HLA-A*33ÓëÁÙ´²Ö¸±êסԺʱ¼äÒÔ¼°ÑªÌÇˮƽµÄ¹ØÏµ

×îºó£¬£¬Ñо¿Ö°Ô±Ô¤²âÁËGFAPÂѰ×ÖÐÓëHLA-A*3303ºÍDPB1*0501ÕâÁ½¸ö¼²²¡Ïà¹ØHLA·Ö×ÓÁ¬ÏµµÄëĶΣ¬£¬²¢ÇÒ¶ÔÕâЩëĶÎÓëÏìÓ¦µÄHLA·Ö×ÓµÄÏ໥×÷ÓþÙÐÐÁËÈýά½á¹¹µÄÄ£ÄâÆÊÎö£¨Í¼2£©¡£¡£¡£¡£

0D21AD43FA80AF320689EB5870E_9E99FBD3_17D1E

ͼ2 HLA-GFAPÂѰ×Ï໥×÷ÓõÄÈýά½á¹¹Ä£Äâ

±¾Ñо¿ÌáÐÑ×ÔÉí·´Ó³ÐÔTϸ°û (ÓÈÆäÊÇCD8+ T ϸ°û) ¼ÓÈëÁËGFAP-A¼²²¡µÄ±¬·¢ºÍÏ£Íû¡£¡£¡£¡£Òò´Ë£¬£¬¸ÃÑо¿Ê×´ÎÕ¹ÏÖHLAµÈÒÅ´«ÒòËØÔÚGFAP-A·¢²¡ÖеÄ×÷Ó㬣¬²»µ«ÎªGFAP-AÒÅ´«ÃâÒßÑо¿µÓÚ¨»ù´¡£¡£¡£¡£¬£¬»¹ÎªÁÙ´²¾«×¼ÖÎÁÆGFAP-AÌṩÐÂ˼Ð÷¡£¡£¡£¡£

½üÄêÀ´£¬£¬ÄÔ²¡ÖÐÐÄÇñΰ¡¢¡¢¡¢ÊæÑÂÇå¿ÎÌâ×éÒ»Ö±ÖÂÁ¦ÓÚ×ÔÉíÃâÒßÐÔÄÔÑ×ÕâÒ»ÀàÓÐÊý²¡ÁÙ´²Óë»ù´¡Ñо¿¡£¡£¡£¡£ÁªºÏº£ÄÚÙÉÐУ¬£¬½¨ÉèÁÙ´²ÐÐÁУ¬£¬¿ÎÌâ×é´ÓÒÅ´«²¡Òòѧ¡¢¡¢¡¢»úÖÆ¡¢¡¢¡¢Õï¶Ï±ê¼ÇÎïµÈ¶àά¶È¾ÙÐÐÉîÈë̽ÌÖ£¬£¬È¡µÃÁËһϵÁÐÔ­´´ÐÔÑо¿Ð§¹û£º£º£ºÊ״η¢Ã÷ÁË×ÔÉíÃâÒßÄÔÑ×˯ÃßÏà¹ØµÄÄÔµçÉúÎï±ê¼ÇÎNeurology£¬£¬2024£¬£¬ÒÑÎüÊÕ£©£»£»£»Ê״ι¹½¨NMDARÄÔÑ×µÄÈËÔ´»¯Ð¡ÊóÄ£×Ó£¨Journal of Neuroinflammation£¬£¬2023£©£»£»£»Ê״ᨵÀNMDARÄÔÑ×Ò׸лùÒòHLA_DRB1*16:02£¨Journal of Neurology, Neurosurgery, and Psychiatry£¬£¬2019£©µÈ¡£¡£¡£¡£Î´À´£¬£¬Á¥ÊôµÚÈýÒ½ÔºÄÔ²¡ÖÐÐĽ«¼ÌÐøÒÀÍйú¼ÒÉñ¾­ÇøÓòÒ½ÁÆÖÐÐÄ£¨ÖÐÄÏÇø£©µÄ½¨É裬£¬È«Á¦Ê©Õ¹Éñ¾­ÃâÒßÍŶӵÄÑÇר¿ÆÓÅÊÆ£¬£¬Æð¾¢Ó뺣ÄÚ¡¢¡¢¡¢ÍâÑóÙÉÐÐÏàÖúÑо¿£¬£¬Ôö½øÕïÁÆË®Æ½ÌáÉý£¬£¬¸üºÃÖª×ãÈËÃñȺÖÚ¿µ½¡ÐèÇ󡣡£¡£¡£

Ô­ÎÄÁ´½Ó: https://doi.org/10.1002/ana.26899

¡¾ÍøÕ¾µØÍ¼¡¿