ngµç×ÓÓÎÏ·

05

¿ÆÑÐÏ£Íû

ngµç×ÓÓÎÏ·ÍŶÓÕ¹ÏÖ¸ÎÔàÐàÂõÏà¹ØÐÔËðÉ˵ĻúÖÆ

¸å¼þȪԴ£º£º£ºÁ¥ÊôµÚÈýÒ½Ôº ±à¼­£º£º£ºÌ¸Ï£¡£¡£¡¢ ¡¢Íõ¶¬Ã· ÉóºË£º£º£ºËïÒ«±ó ÔĶÁÁ¿£º£º£º

ngµç×ÓÓÎÏ·ÐÂÎÅÍøÑ¶£¨Í¨Ñ¶Ô±Ò¶ÁÖÉ­£©¿ËÈÕ£¬£¬ngµç×ÓÓÎÏ·Á¥ÊôµÚÈýÒ½Ôº¸ÎÔàÍâ¿ÆÑîÑï½ÌÊÚÍŶÓÔÚ¸ÎÔಡѧ¶¥¼¶ÆÚ¿¯HepatologyÔÚÏß½ÒÏþÌâΪ¡°Single-cell immune profiling of mouse liver aging reveals Cxcl2+ macrophages recruit neutrophils to aggravate liver injury¡±µÄÑо¿ÂÛÎÄ¡£ÉîÈë̽ÌÖÁËCxcl2+¾ÞÊÉϸ°ûͨ¹ýCXCL2-CXCR2ÖáÇý¶¯µÄÖÐÐÔÁ£Ï¸°ûÕÙļ»úÖÆ£¬£¬²¢ÌṩÁËDZÔÚµÄÖÎÁÆÕ½ÂÔ£¬£¬ÒÔÓ¦¶ÔÓëÄêËêÏà¹ØµÄ¸ÎËðÉË¡£ÂÛÎĵÄÅäºÏͨѶ×÷ÕßΪngµç×ÓÓÎÏ·Á¥ÊôµÚÈýÒ½Ôº¸ÎÔàÍâ¿ÆÑîÑï½ÌÊÚ¡¢ ¡¢ÕÅÓ¢²Å½ÌÊÚ¡¢ ¡¢Ö£¿£¿£¿¡Ö÷ÖÎҽʦÒÔ¼°ngµç×ÓÓÎÏ·ÖÐɽҽѧԺÑÈÙ½ÌÊÚ¡£

Ë¥×ÜÊǸβ¡µÄÖ÷Òª·çÏÕÒòËØ£¬£¬ÌåÏÖΪ¸ÎÔÙÉúÄÜÁ¦ÏÔÖøÏ½µ¡¢ ¡¢Ö¬ÖÊ»ýÀÛÐÄÀíÐÔÔöÌíºÍÏËά»¯Ï£Íû¼ÓËÙ¡£×÷Ϊһ¸öÖ÷ÒªµÄÃâÒ߯÷¹Ù£¬£¬¸ÎÔàÓµÓÐÖØ´óµÄ¸ÎÄÚÃâÒßϸ°ûÍøÂç¼°Ï໥×÷Óá£ÐàÂõ»áÏÔÖø¸Ä±äפÁôÃâÒßϸ°ûµÄ×é³É£¬£¬½ø¶øÔöÌí¸ÎÔà¶ÔÓëÐàÂõÏà¹Ø¼²²¡£¨Èç¸Î°©¡¢ ¡¢¸ÎÓ²»¯ºÍÖ¬·¾¸Î²¡£©µÄÒ׸ÐÐÔ£¬£¬ÐγɶñÐÔÑ­»·¡£Òò´Ë£¬£¬ÆÈÇÐÐèÒªÉîÈëÏàʶ¸ÎÔàÐàÂõÀú³ÌÖоֲ¿ÃâÒß΢ÇéÐεĶ¯Ì¬×ª±ä£¬£¬Õâ¶Ô¿ÆÑ§Ñо¿ºÍÁÙ´²ÖÎÁƾßÓÐÖ÷ÒªÒâÒå¡£

¿ÆÑ§¼Òͨ³£Ê¹ÓÃBulk-RNA-seqÊÖÒÕÀ´Ñо¿ÉúÎïѧ»úÖÆ¡£È»¶ø£¬£¬ÕâÖÖÒªÁì¿ÉÄÜÑÚÊÎÁËϸ°ûȺÄÚ²¿Çý¶¯¹¦Ð§ÒìÖÊÐÔµÄת±ä¡£×î½ü£¬£¬µ¥Ï¸°ûRNA²âÐòÊÖÒյĿªÕ¹Ê¹µÃÎÒÃÇÄܹ»ÍøÂçÕû¸ö¸ÎÔàµÄϸ°ûת¼×éÊý¾Ý£¬£¬²¢ÆÊÎö·¢²¡Àú³ÌÖÐÌØ¶¨Ï¸°ûÀàÐ͵Äת±ä¡£ÒѾ­ÓйØÓÚ¸ÎÔàµÄµ¥Ï¸°ûRNA²âÐòÑо¿±¨µÀ£¬£¬ÕâЩÑо¿Ö§³ÖÎÒÃÇ̽ÌÖÔÚСÊó¡¢ ¡¢´óÊóºÍÈËÀàÐàÂõÀú³ÌÖжà¸öϸ°ûȺµÄТ˳¡£È»¶ø£¬£¬ÔÚÒÑÍùµÄÑо¿ÖУ¬£¬¶Ô¸ÎÔàÄÚ²¿ÃâÒßϸ°ûµÄ±¨µÀÏà¶Ô½ÏÉÙ¡£±ðµÄ£¬£¬Ë¥×ÜÊÇÒ»¸öÒ»Ö±¶¯Ì¬¸Ä±äµÄÀú³Ì£¬£¬Òò´ËÎÒÃÇÐèÒª¶Ô¸ÎÔàÐàÂõÀú³Ì¾ÙÐÐÖÜÈ«µÄÐÎò£¬£¬¶ø²»µ«½ö½«Æä·ÖΪÁ½¸ö½×¶Î£¨ÇàÄêºÍÍíÄ꣩¡£

ΪÏàʶ¾öÉÏÊöÎÊÌ⣬£¬Ñо¿Ö°Ô±×¨×¢ÓÚ¸ÎÔàÃâÒß΢ÇéÐΣ¬£¬ÆÀ¹ÀÁËСÊó¸ÎÔàÐàÂõÀú³ÌÖÐÃâÒßϸ°ûµÄ»ùÒò±í´ïת±ä¡£¸ÃÑо¿º­¸ÇÁËÐÂÉú¶ù¡¢ ¡¢²¸ÈéÆÚ¡¢ ¡¢ÇàÄêºÍÍíÄêËĸö½×¶Î£¬£¬½¨ÉèÁËÏÖÔÚ¸ÎÔàÐàÂõÑо¿ÖÐ×î´óµÄÃâÒßϸ°ûͼÆ×¡£½øÒ»²½µÄÑо¿·¢Ã÷£¬£¬ÔÚÍíÄêСÊóµÄ¸ÎÔàÖУ¬£¬¸»¼¯µÄCxcl2+¾ÞÊÉϸ°ûÌåÏÖ³öÐàÂõÏà¹ØÉøÍ¸±íÐÍ£¨SASP£©£¬£¬²¢Í¨¹ýCXCL2-CXCR2ÖáÎüÒýÖÐÐÔÁ£Ï¸°û½øÈëÍíÄê¸ÎÔà¡£Ëæºó£¬£¬ÕâЩCxcl2+¾ÞÊÉϸ°ûÉøÍ¸µÄIL-1¦ÂºÍTNF-¦Á´Ì¼¤ÁËÖÐÐÔÁ£Ï¸°û°ûÍâÓÕ²¶Íø£¨NETs£©µÄÐγÉ£¬£¬¶øÌ«¹ýµÄNETs»ýÀÛµ¼Ö¸ÎÔàËðÉË¡£ÕâÏîÑо¿ÍêÉÆÁ˸ÎÔàÃâÒß΢ÇéÐÎÔÚµ¥Ï¸°ûˮƽÉÏÐàÂõÀú³ÌÖеĶ¯Ì¬×ª±äÀú³Ì£¬£¬²¢È·¶¨ÁËCXCL2-CXCR2ÐźÅÖáÔÚ¸ÄÉÆÓëÄêËêÏà¹Ø¸ÎËðÉËÖеĽ¹µã×÷Óá£ÕâÒ»·¢Ã÷¹ØÓÚÉîÈëÃ÷È·¸ÎÔàÐàÂõµÄ·Ö×Ó»úÖÆÒÔ¼°¿ª·¢Ïà¹ØÖÎÁÆÕ½ÂÔ¾ßÓÐÖ÷ÒªÒâÒå¡£

6867D3B361E57C737467BCF14D6_FDD22FA2_14BA2

»úÖÆÄ£Ê½Í¼


ÂÛÎÄÁ´½Ó£º£º£ºhttps://journals.lww.com/hep/abstract/9900/single_cell_immune_profiling_of_mouse_liver_aging.558.aspx

¡¾ÍøÕ¾µØÍ¼¡¿