ngµç×ÓÓÎÏ·ÐÂÎÅÍøѶ£¨Í¨Ñ¶Ô±ÕÅæÃæᢴ÷Ï£°²¡¢¼òÎÄÑ10ÔÂ18ÈÕ£¬ £¬ngµç×ÓÓÎÏ·Á¥ÊôµÚÁùÒ½Ôº¸Ø³¦Íâ¿ÆÈζ«ÁÖ¡¢ÁÖºê³ÇÍŶÓÔÚ½áÖ±³¦°©ÁìÓòµÄ×îÐÂÑо¿Ð§¹û¡°Cancer-associated fibroblasts undergoing neoadjuvant chemotherapy suppress rectal cancer revealed by single-cell and spatial transcriptomics¡±ÒÔÔ´´ÂÛÖøµÄÐÎʽÔÚCell Reports MedicineÕýʽ½ÒÏþ¡£¡£
¸ÃÑо¿ÓëÉîÛÚ»ª´óÉúÃü¿ÆѧÑо¿ÔºÁõʯƽÑо¿Ô±ÍŶӡ¢»ªÄÏÀí¹¤´óѧÉúÎï¿ÆѧÓ빤³ÌѧԺÍõ¾Õ·¼½ÌÊÚÍŶÓÏàÖúÍê³É¡£¡£Á¥ÊôµÚÁùÒ½Ôº»ÆÁÁ¸±Ö÷ÈÎҽʦ¡¢²©Ê¿ºó³Â»ªÏÔΪÂÛÎÄÅäºÏµÚÒ»×÷Õߣ¬ £¬Á¥ÊôµÚÁùÒ½ÔºÈζ«ÁÖ½ÌÊÚ¡¢ÁÖºê³Ç¸±Ö÷ÈÎҽʦΪÅäºÏͨѶ×÷Õß¡£¡£
½áÖ±³¦°©ÊÇÈ«ÇòµÚÈý´ó×î³£¼ûµÄ¶ñÐÔÖ×Áö¡£¡£ÔÚÖйú£¬ £¬Ö±³¦°©»¼ÕßËùÕ¼µÄ±ÈÀý¸ßÓÚÎ÷·½¹ú¼Ò¡£¡£¾Ö²¿Ï£ÍûÆÚÖ±³¦°©»¼Õß½ÓÊÜи¨Öú»¯ÁÆ£¬ £¬¿ÉÏÔÖøÌáÄÜÊÖÊõÇгýÂÊ£¬ £¬½µµÍ¾Ö²¿¸´·¢ÂÊ£¬ £¬²¢¿É¹æ±Ü·ÅÁÆ´øÀ´µÄ·çÏÕ¡£¡£
Ö×ÁöÃâÒß΢ÇéÐÎÏÔÖøµØÓ°ÏìÖ×ÁöÖÎÁÆЧ¹û¡£¡£Ô½À´Ô½¶àµÄÑо¿Ö¸³öи¨Öú»¯ÁƲ»µ«¾ßÓл¯ÁÆÒ©Îï¶ÔÖ×Áöϸ°ûµÄÖ±½ÓɪË×÷Ó㬠£¬²¢ÇÒ»¹¼ÓÈëµ÷ÀíÖ×Áö΢ÇéÐΣ¬ £¬Æô¶¯¿¹Ö×ÁöÃâÒߣ¬ £¬´Ó¶øʵÏÖÖ×ÁöÖÎÁÆ×÷Óᣡ£ÁíÍâи¨Öú»¯ÁƵÄÁÆЧ²»¼ÑÒ²ÓëÖ×Áö΢ÇéÐεÄÃâÒßÒÖÖÆÏà¹Ø¡£¡£È»¶ø£¬ £¬Ð¸¨Öú»¯ÁƵÄÃâÒßµ÷Àí×÷ÓûúÖÆÉв»ÇåÎú¡£¡£
˼Á¿µ½ÉÏÊöÎÊÌ⣬ £¬Èζ«ÁÖ¡¢ÁÖºê³ÇÍŶÓÕÐļÁË29ÀýÖ±³¦°©»¼Õߣ¬ £¬ÔÚи¨Öú»¯ÁÆÇ°ºó»®·ÖÈ¡Ñù£¬ £¬²¢¶ÔÑù±¾¾ÙÐÐÁ˵¥Ï¸°ûת¼×é²âÐòºÍ¿Õ¼äת¼×é²âÐò¡£¡£Ñо¿ÍŶÓƾ֤ÁÆЧ½«ÑùÌìְΪCR£¨ÍêÈ«»º½â£©¡¢PR£¨²¿·Ö»º½â£©ºÍNR£¨ÎÞÏÔ×Å»º½â£©Èý¸ö·Ö×é¾ÙÐÐÖÎÁÆÇ°ºóºÍ²î±ðÁÆЧ֮¼äµÄ¶àά¶ÈÆÊÎö£¬ £¬¹¹½¨ÁËÖ×Áö΢ÇéÐÎÔÚи¨Öú»¯ÁÆÇ°ºó¶¯Ì¬×ª±äµÄϸ°ûͼÆ×£¬ £¬ÊµÏÖÖ×Áö΢ÇéÐÎÔõÑùÓ°Ïìи¨Öú»¯ÁÆÁÆЧµÄϵͳÑо¿¡£¡£
Ñо¿ÍŶÓÊ״η¢Ã÷и¨Öú»¯ÁƶÔ΢ÇéÐÎÖеĶàÖÖϸ°ûÒòËر¬·¢ÁËÖ÷ÒªÓ°Ï죬 £¬²¢ºÍÁÆЧÏà¹Ø¡£¡£ÖµµÃ×¢ÖصÄÊÇ£¬ £¬Ñо¿ÍŶӷ¢Ã÷Ö×ÁöÏà¹Ø³ÉÏËάϸ°û£¨CAFs£©ÔÚи¨Öú»¯ÁÆÖб»ÏÔ×ÅÖØËÜ£¬ £¬·Ö»¯³öÁËеÄϸ°ûÑÇÐÍ£¬ £¬Õ¹ÏÖÁËCAFsÑÇȺµÄÖØ´óÐÔÒÔ¼°Ö×ÁöÔö½øºÍÃâÒß¼¤»îµÄË«ÖØ×÷Óᣡ£Ò»·½Ã棬 £¬Ò»²¿·ÖµÄCAFs£¨CAF_PI16¡¢CAF_SLIT2ºÍCAF_ADAM28£©Óëи¨Öú»¯ÁÆÁÆЧÏà¹Ø£¬ £¬ÇÒÕâЩCAFs¿Éͨ¹ýÉø͸CXCL12¡¢SLIT2ºÍDCN¶ÔCD8+ЧӦTϸ°ûºÍÊ÷ͻ״ϸ°û¾ÙÐи»¼¯ºÍ»î»¯£¬ £¬½ø¶øÊ©Õ¹¿¹Ö×ÁöÃâÒߣ¬ £¬ÒÖÖÆÖ×ÁöµÄÏ£Íû¡£¡£ÁíÒ»·½Ã棬 £¬²¿·ÖCAFÑÇȺ±í´ï´ó×ÚÓëѪ¹ÜÌìÉú¡¢ECMÖØËÜ¡¢EMTºÍÖ×ÁöÇÖÏ®µÈ´ÙÖ×Áö¹¦Ð§Ïà¹Ø»ùÒò¡£¡£Ñо¿ÍŶÓÊӲ쵽CAF_FAPͨ¹ýMIR4435 - 2HGÔöÇ¿Ö×ÁöEMT£¬ £¬²¢Óë½Ï²îµÄи¨Öú»¯ÁÆÁÆЧÏà¹Ø¡£¡£
Ñо¿Ê¾Òâͼ
×ÛÉÏËùÊö£¬ £¬¸ÃÑо¿Ê×´Îͨ¹ýµ¥Ï¸°û²âÐòÁªºÏ¿Õ¼äת¼×éÊÖÒÕ£¬ £¬ÆÊÎöÁËи¨Öú»¯ÁÆÖØËÜÖ±³¦°©Ö×Áö΢ÇéÐεÄÀú³Ì£¬ £¬Á¢ÒìÐÔµØÌá³öÁ˳ÉÏËάϸ°ûÓëи¨Öú»¯ÁÆÃâÒßÓ¦´ðµÄ¹Øϵ¼°»úÖÆ£¬ £¬ÎªÖ±³¦°©Ð¸¨Öú»¯ÁÆ»úÖÆÑо¿¼°×ª»¯Ñо¿ÁìÓòÌṩÁËÖ÷ÒªµÄ;¾¶ºÍ˼Ð÷£¬ £¬Îª½øÒ»²½Ì½Ë÷¸üÓÐÓõÄÖ×Áöи¨ÖúÖÎÁÆÕ½ÂÔÌṩÁËÐÂÆ«Ïò¡£¡£
ÂÛÎÄÁ´½Ó£º£ºhttps://www.cell.com/cell-reports-medicine/fulltext/S2666-3791(23)00408-1
µØµã:¹ãÖÝÊÐиÛÎ÷·135ºÅ Óʱà:510275
µç»°: 020-84112828
ngµç×ÓÓÎÏ·°æȨËùÓÐ COPYRIGHT?1999-2022 , SUN YAT-SEN UNIVERSITY