ngµç×ÓÓÎÏ·ÐÂÎÅÍøÑ¶£¨Í¨Ñ¶Ô±ÕżҾü£©±±¾©Ê±¼ä2022Äê12ÔÂ30ÈÕ£¬£¬£¬¹ú¼Ê¸ßˮƽѧÊõÆÚ¿¯Nucleic Acids Research£¨IF=19.160£©ÔÚÏß½ÒÏþÁËngµç×ÓÓÎÏ·ÊýѧѧԺ£¨¹ã¶«Ê¡ÅÌËã¿ÆÑ§ÖØµãʵÑéÊÒ£©ÕżҾü½ÌÊÚ¿ÎÌâ×éµÄ¿ÆÑÐЧ¹û¡°Genome-wide inference reveals that feedback regulations constrain promoter-dependent transcriptional burst kinetics¡±£¬£¬£¬¸ÃЧ¹ûËù½¨ÉèµÄÊýѧģ×ÓºÍͳ¼ÆÍƶÏÒªÁìΪÑо¿×ªÂ¼±¬·¢¶¯Á¦Ñ§ÌṩÁËÒ»ÖÖÎÞаÓÐÓõÄÒªÁ죬£¬£¬Ëù»ñµÃµÄЧ¹û½«ÓÐÖúÓÚÃ÷ȷϸ°û·¢ÓýºÍÔËÆø¾öÒé¡£¡£¡£ngµç×ÓÓÎÏ·ÊýÑ§Ñ§ÔºÂæáÔºÀ²©Ê¿ºÍÍõ×ÓºÀ²©Ê¿ºóΪÅäºÏµÚÒ»×÷Õߣ¬£¬£¬ÕÅÛÚȪ²©Ê¿ºóΪÅäÏàÖúÕß¡£¡£¡£ngµç×ÓÓÎÏ·ÊýѧѧԺÖÜÌìÊÙ½ÌÊÚΪÅäºÏͨѶ×÷Õߣ¬£¬£¬ÕżҾü½ÌÊÚΪ×îºóͨѶ×÷Õß¡£¡£¡£
ÓÉËæ»úÀú³ÌÒýÆðµÄ»ùÒò±í´ï¿É±äÐÔÒѳÉΪÑо¿»ùÒòµ÷¿ØµÄÒ»¸ö½¹µã¹Ø×¢µã¡£¡£¡£»£»£»ùÒòͨ³£ÒÔ²»Á¬ÐøµÄ±¬·¢·½Ê½Ëæ»úת¼¡£¡£¡£×ªÂ¼±¬·¢±»ÒÔΪÊÇ»ùÒò±í´ïËæ»úÐÔµÄÖ÷ÒªÊðÀí£¬£¬£¬²¢ÓÐÖúÓÚϸ°û¼äµÄ±äÒìÐÔ£¬£¬£¬¿ÉÊǵ÷¿Ø×ªÂ¼±¬·¢¶¯Á¦Ñ§µÄ·Ö×Ó»úÖÆÈÔÈ»ÄÑÒÔ×½Ãþ¡£¡£¡£Ðí¶àʵÑéÑо¿ÒѾΪ¾²Ì¬Æô¶¯×ӽṹºÍÐòÁÐÓëת¼±¬·¢ÒÔ¼°Óɴ˵¼ÖµĻùÒò±í´ï¿É±äÐÔÖ®¼äµÄÁªÏµÌṩÁËÖ¤¾Ý¡£¡£¡£ÕâÖֿɱäÐÔ¿ÉÒÔͨ¹ýÖØ´óµÄµ÷¿ØÍøÂç´ÓmRNAÈö²¥µ½ÂѰ×ÖÊ£¬£¬£¬²¢½øÒ»²½Èö²¥µ½ÏÂÓΰлùÒò¡£¡£¡£ÕâÌá³öÁËÖ÷ÒªµÄÎÊÌ⣺£ºÔÚÈ«»ùÒò×鹿ģÄÚ£¬£¬£¬¾²Ì¬Æô¶¯×Óµ÷¿ØÐòÁÐÔõÑù±àÂëת¼±¬·¢¶¯Á¦Ñ§£¬£¬£¬¶¯Ì¬»ùÒòµ÷¿ØÍøÂçÔõÑùÐγɱ¬·¢¶¯Á¦Ñ§?

ͼ1 Ò»ÖÖÄ£×ÓÓëÊý¾Ý¡°Ë«Çý¶¯¡±µÄÈ«»ùÒò×éͳ¼ÆÍƶϿò¼Ü
ÔÚÕâÀ£¬£¬¿ÎÌâ×éÑо¿Ö°Ô±¿ª·¢ÁËÒ»¸ö»ùÓÚÄ£×ÓÇý¶¯ºÍÊý¾ÝÇý¶¯×éºÏµÄͳ¼Æ¿ò¼Ü£¬£¬£¬ÒÔÖ´ÐпÉÀ©Õ¹µÄÈ«»ùÒò×éÍÆ¶Ï¡£¡£¡£¸Ã¿ò¼ÜʹÓÃscRNA-seqÊý¾ÝµÄ¾²Ì¬¿ìÕÕÀ´ÍƶÏת¼±¬·¢¶¯Á¦Ñ§µÄµ÷¿Ø»úÖÆ¡£¡£¡£Ïêϸ¶øÑÔ£¬£¬£¬ËüÕûºÏÁË»ùÒò±í´ï¿É±äÐÔ¡¢¡¢±¬·¢ÆµÂÊ¡¢¡¢±¬·¢¾ÞϸºÍ·´À¡µ÷¿ØÐÎʽµÈÐÅÏ¢¡£¡£¡£½«´ËÍÆ¶ÏÒªÁìÓ¦ÓÃÓÚСÊóÅßÌ¥³ÉÏËάϸ°ûscRNA-seqÊý¾Ý£¬£¬£¬ÎÒÃÇ·¢Ã÷·´À¡ÒÔ²î±ðµÄ·½Ê½µ÷Àí±¬·¢ÆµÂʺ;Þϸ£¬£¬£¬TATA»ùÒò½öÔÚÕý·´À¡±£´æµÄÇéÐÎÏÂÒԸ߱¬·¢ÆµÂʱí´ï£¬£¬£¬·´À¡µ÷¿ØÒþ²ØÁËTSSÂþÑܶÔת¼±¬·¢¶¯Á¦Ñ§µÄÓ°Ï죬£¬£¬ÒÔ¼°E -PÏ໥×÷ÓÃÖ»ÓÐÔÚÕý·´À¡±£´æµÄÇéÐÎÏ£¬£¬£¬²ÅÖ÷Òªµ÷Àí±¬·¢ÆµÂÊ¡£¡£¡£¼òÆÓµØËµ£¬£¬£¬ÎÒÃÇ·¢Ã÷ÔÚûÓз´À¡µ÷¿ØµÄÇéÐÎÏ£¬£¬£¬È«»ùÒò×éת¼±¬·¢¶¯Á¦Ñ§µÄÌØÕ÷ÓëÓз´À¡µ÷¿ØµÄÇéÐÎϲî±ð£¬£¬£¬ÕâÒâζ×ÅSimpsonã£ÂÛ£¬£¬£¬Ò»¸öÓÐȤµÄͳ¼ÆÕ÷Ï󡣡£¡£

ͼ2 Æô¶¯×ÓÓë·´À¡µ÷¿ØÅäºÏÐ×÷µ÷Àíת¼±¬·¢¶¯Á¦Ñ§
ÕâÏîÊÂÇé»ñµÃÁ˹ú¼ÒÖØµãÑз¢ÍýÏëÏîÄ¿¡¢¡¢¹ú¼Ò×ÔÈ»¿ÆÑ§»ù½ð¡¢¡¢¹ã¶«»ù´¡ºÍÓ¦Óûù´¡Ñо¿»ù½ð¡¢¡¢¹ãÖÝÒªº¦ÁìÓòºÍ¿ªÕ¹ÍýÏëÏîÄ¿ºÍ¹ã¶«ngµç×ÓÓÎÏ·ÅÌËã¿ÆÑ§Ê¡ÖØµãʵÑéÊÒµÈÏîÄ¿µÄ×ÊÖú¡£¡£¡£
ÂÛÎÄÁ´½Ó£º£ºhttps://academic.oup.com/nar/advance-article/doi/10.1093/nar/gkac1204/6965449