ngµç×ÓÓÎÏ·ÐÂÎÅÍøѶ£¨Í¨Ñ¶Ô±Â½¹ã°²£©ÉúÎïÔÚ·¢ÓýÀú³Ì±£´æÇþµÀ»¯£¨canalization£©µÄÌØÕ÷¡£¸ÃÌØÕ÷ÌåÏÖΪÉúÎïÌåÔÚ·¢ÓýÀú³ÌÖÐÄܹ»»º³åÖÖÖÖÄÚÔ´»òÍâÔ´µÄÈŶ¯£¨perturbation£©£¬£¬£¬Î¬³Ö±íÐ͵ÄÎÈ̬¡£ÔÚ1942Ä꣬£¬£¬ÒÅ´«Ñ§¼ÒC.H.Waddington µÄÔËÓÃË®Á÷ÑØ׿ȶ¨¹µÇþÁ÷¶¯µÄ±ÈÓ÷£¬£¬£¬Ìá³öÁËÇþ»¯Ð§Ó¦µÄ¿´·¨£¬£¬£¬µÓÚ¨Á˱íÐÍÎÈ̬ά³ÖµÄÀíÂÛ»ù´¡¡£½üÄêÀ´£¬£¬£¬¹ØÓÚ±íÐÍÎÈ̬µÄ·Ö×Ó»úÖÆÑо¿ÒÑ´ÓÓÐÏ޵ĵ÷¿Ø»Ø·ÍØÕ¹ÖÁ±í´ïµ÷¿ØÄ£¿é£¬£¬£¬ÉõÖÁÖØ´óµÄ¶à»ùÒò»¥×÷µ÷¿ØÍøÂç¡£ÒÑÓÐÑо¿ÌáÐÑ£¬£¬£¬»ùÒò×éÖеÄmicroRNA¿ÉÒÔͨ¹ýÔöÌí»ùÒò±í´ïµ÷¿ØÍøÂçµÄÎȹÌÐÔ£¬£¬£¬Î¬³Ö±íÐ͵ÄÎÈ̬£»£»£»È»¶øʵ֤µÄÑо¿ÈÔȻȱ·¦¡£
ΪÁËÑо¿microRNA½éµ¼µÄÇþ»¯µ÷¿Ø¹¦Ð§£¬£¬£¬ngµç×ÓÓÎÏ·ÉúÃü¿ÆѧѧԺÉúÃü×éѧƫÏòÎâÖÙÒå½ÌÊÚÍŶÓÒÔģʽÎïÖÖ¹ûӬΪÑо¿Ä£×Ó£¬£¬£¬Í¨¹ýÇõÍdicer-1 µÄ±í´ï£¬£¬£¬ÆÕ±éÇÒ΢ÈõµØϵ÷¹ûÓ¬»ùÒò×éÖеÄÇþ»¯µ÷¿Ø·Ö×Ó£¬£¬£¬microRNAµÄ±í´ïˮƽ£¬£¬£¬ÒÔ´Ë×÷ΪÑо¿ÏµÍ³£¨Í¼1£©Ì½ÌÖmicroRNA½éµ¼µÄÇþ»¯µ÷¿ØЧӦ¡£Ñо¿·¢Ã÷µ±microRNA±í´ïˮƽ±»ÕûÌåµ÷µÍʱ£¬£¬£¬×ªÂ¼µ÷¿ØÍøÂçÔÚ¶ÌÆÚÄÚÊÕµ½µÄÓ°ÏìºÜ΢Èõ£¬£¬£¬Ïà±È֮ϣ¬£¬£¬Í¨¹ýÏàͬҪÁìÆÕ±éÇõÍÆäËûµ÷Àí»ùÒò£¨ÓÈÆäÊÇת¼Òò×Ó£©£¬£¬£¬¿Éµ¼ÖÂת¼µ÷¿ØÍøÂçµÄÇ¿ÁҸı䡣ÔÚ±íÐͲãÃ棬£¬£¬dicer-1 Çõ͹ûÓ¬ÔÚ·¢ÓýÀú³ÌÖлáÖð½¥Æ«ÀëÆä¼È¶¨µÄ·¢Óý¹ì¼££¬£¬£¬ÔÚ¸öÌå·¢ÓýµÄºóÆÚ³ÊÏÖÑÏÖرíÐÍȱÏÝ£¨ÖîÈçÊÙÃüËõ¶Ì£©£¬£¬£¬ÌåÏÖ³öÏÔÖøµÄÈ¥Çþ»¯£¨De-canalization£©ÌØÕ÷¡£¸ÃЧ¹ûÅú×¢£¬£¬£¬ËæןöÌå·¢ÓýµÄ¾ÙÐУ¬£¬£¬ÇéÐÎÈŶ¯Ëù´øÀ´µÄÎó²î½«Ò»Ö±»ýÀÛ£¬£¬£¬Ô½ÊÇ·¢ÓýµÄºóÆÚ£¬£¬£¬»ùÒòµ÷¿ØÍøÂçÔ½ÐèÒªÇþ»¯Ð§Ó¦·Ö×ÓÀ´Î¬³ÖÆäÎȹ̡£ÕâÒ»·¢Ã÷ÂÊÏÈ´Óʵ֤µÄ½Ç¶È֤ʵÁËmicroRNAÊÇ»ùÒò×éÖеÄÖ÷ÒªÇþ»¯Ð§Ó¦·Ö×Ó£¬£¬£¬¿Éͨ¹ý»º³åÉúÎï¸öÌå·¢ÓýÀú³ÌÖгÖÐø±£´æµÄ¡¢ ¡¢Î¢ÈõµÄÈŶ¯£¬£¬£¬ÔöÌíת¼µ÷¿ØÍøÂçµÄÎȹÌÐÔ£¬£¬£¬½ø¶øά³Ö±íÐ͵ÄÎÈ̬£¬£¬£¬ÎªÉîÈëÃ÷È··¢ÓýÇþµÀ»¯ÌØÕ÷µÄÒÅ´«»úÖÆÌṩÁËеÄÆôʾ¡£
ͼ1. ¹ûÓ¬microRNA½éµ¼µÄÇþ»¯µ÷¿ØÑо¿ÏµÍ³¡£Í¼ÖÐʾÒâºÚ¸¹¹ûÓ¬dicer-1ÇõÍƷϵ£¬£¬£¬ÔÚ¸ÃÒÅ´«Åä¾°ÖУ¬£¬£¬»ùÒò×éÖÐmicroRNAµÄ±í´ïˮƽ±»ÆÕ±éÇÒ΢ÈõµØϵ÷¡£
¸ÃÂÛÎÄ¡°Canalization of Phenotypes¡ªWhen the Transcriptome is Constantly but Weakly Perturbed¡±£¬£¬£¬ÓÚ2023Äê1ÔÂÔÚ½ø»¯ÒÅ´«Ñ§¹ú¼ÊÖ÷Á÷ÆÚ¿¯ Molecular Biology and Evolution½ÒÏþ¡£ngµç×ÓÓÎÏ·ÉúÃü¿ÆѧѧԺÊǵÚÒ»×÷Õßµ¥Î»¡£¸ÃÊÂÇéÊܵ½¹ú¼Ò×ÔÈ»¿Æѧ»ù½ð¡¢ ¡¢¹ã¶«Ê¡×ÔÈ»¿Æѧ»ù½ð¡¢ ¡¢Öйú²©Ê¿ºó»ù½ð¡¢ ¡¢¹ã¶«Ê¡ÖصãÑз¢ÏîÄ¿ºÍÄÏ·½º£Ñó¿ÆѧÓ빤³Ì¹ã¶«Ê¡ÊµÑéÊÒ£¨Ö麣£©Á¢ÒìÍŶÓÏîÄ¿µÄ×ÊÖú¡£
ÂÛÎÄÁ´½Ó: https://academic.oup.com/mbe/article/40/1/msad005/6974681
µØµã:¹ãÖÝÊÐиÛÎ÷·135ºÅ Óʱà:510275
µç»°: 020-84112828
ngµç×ÓÓÎÏ·°æȨËùÓÐ COPYRIGHT?1999-2022 , SUN YAT-SEN UNIVERSITY