ngµç×ÓÓÎÏ·ÐÂÎÅÍøѶ£¨Í¨Ñ¶Ô±Â½¹ã°²£©ÉúÎïÔÚ·¢ÓýÀú³Ì±£´æÇþµÀ»¯£¨canalization£©µÄÌØÕ÷¡£¡£¡£¸ÃÌØÕ÷ÌåÏÖΪÉúÎïÌåÔÚ·¢ÓýÀú³ÌÖÐÄܹ»»º³åÖÖÖÖÄÚÔ´»òÍâÔ´µÄÈŶ¯£¨perturbation£©£¬Î¬³Ö±íÐ͵ÄÎÈ̬¡£¡£¡£ÔÚ1942Ä꣬ÒÅ´«Ñ§¼ÒC.H.Waddington µÄÔËÓÃË®Á÷ÑØ׿ȶ¨¹µÇþÁ÷¶¯µÄ±ÈÓ÷£¬Ìá³öÁËÇþ»¯Ð§Ó¦µÄ¿´·¨£¬µÓÚ¨Á˱íÐÍÎÈ̬ά³ÖµÄÀíÂÛ»ù´¡¡£¡£¡£½üÄêÀ´£¬¹ØÓÚ±íÐÍÎÈ̬µÄ·Ö×Ó»úÖÆÑо¿ÒÑ´ÓÓÐÏ޵ĵ÷¿Ø»Ø·ÍØÕ¹ÖÁ±í´ïµ÷¿ØÄ£¿é£¬ÉõÖÁÖØ´óµÄ¶à»ùÒò»¥×÷µ÷¿ØÍøÂç¡£¡£¡£ÒÑÓÐÑо¿ÌáÐÑ£¬»ùÒò×éÖеÄmicroRNA¿ÉÒÔͨ¹ýÔöÌí»ùÒò±í´ïµ÷¿ØÍøÂçµÄÎȹÌÐÔ£¬Î¬³Ö±íÐ͵ÄÎÈ̬£»£»È»¶øʵ֤µÄÑо¿ÈÔȻȱ·¦¡£¡£¡£
ΪÁËÑо¿microRNA½éµ¼µÄÇþ»¯µ÷¿Ø¹¦Ð§£¬ngµç×ÓÓÎÏ·ÉúÃü¿ÆѧѧԺÉúÃü×éѧƫÏòÎâÖÙÒå½ÌÊÚÍŶÓÒÔģʽÎïÖÖ¹ûӬΪÑо¿Ä£×Ó£¬Í¨¹ýÇõÍdicer-1 µÄ±í´ï£¬ÆÕ±éÇÒ΢ÈõµØϵ÷¹ûÓ¬»ùÒò×éÖеÄÇþ»¯µ÷¿Ø·Ö×Ó£¬microRNAµÄ±í´ïˮƽ£¬ÒÔ´Ë×÷ΪÑо¿ÏµÍ³£¨Í¼1£©Ì½ÌÖmicroRNA½éµ¼µÄÇþ»¯µ÷¿ØЧӦ¡£¡£¡£Ñо¿·¢Ã÷µ±microRNA±í´ïˮƽ±»ÕûÌåµ÷µÍʱ£¬×ªÂ¼µ÷¿ØÍøÂçÔÚ¶ÌÆÚÄÚÊÕµ½µÄÓ°ÏìºÜ΢Èõ£¬Ïà±È֮ϣ¬Í¨¹ýÏàͬҪÁìÆÕ±éÇõÍÆäËûµ÷Àí»ùÒò£¨ÓÈÆäÊÇת¼Òò×Ó£©£¬¿Éµ¼ÖÂת¼µ÷¿ØÍøÂçµÄÇ¿ÁҸı䡣¡£¡£ÔÚ±íÐͲãÃ棬dicer-1 Çõ͹ûÓ¬ÔÚ·¢ÓýÀú³ÌÖлáÖð½¥Æ«ÀëÆä¼È¶¨µÄ·¢Óý¹ì¼££¬ÔÚ¸öÌå·¢ÓýµÄºóÆÚ³ÊÏÖÑÏÖرíÐÍȱÏÝ£¨ÖîÈçÊÙÃüËõ¶Ì£©£¬ÌåÏÖ³öÏÔÖøµÄÈ¥Çþ»¯£¨De-canalization£©ÌØÕ÷¡£¡£¡£¸ÃЧ¹ûÅú×¢£¬ËæןöÌå·¢ÓýµÄ¾ÙÐУ¬ÇéÐÎÈŶ¯Ëù´øÀ´µÄÎó²î½«Ò»Ö±»ýÀÛ£¬Ô½ÊÇ·¢ÓýµÄºóÆÚ£¬»ùÒòµ÷¿ØÍøÂçÔ½ÐèÒªÇþ»¯Ð§Ó¦·Ö×ÓÀ´Î¬³ÖÆäÎȹ̡£¡£¡£ÕâÒ»·¢Ã÷ÂÊÏÈ´Óʵ֤µÄ½Ç¶È֤ʵÁËmicroRNAÊÇ»ùÒò×éÖеÄÖ÷ÒªÇþ»¯Ð§Ó¦·Ö×Ó£¬¿Éͨ¹ý»º³åÉúÎï¸öÌå·¢ÓýÀú³ÌÖгÖÐø±£´æµÄ ¡¢Î¢ÈõµÄÈŶ¯£¬ÔöÌíת¼µ÷¿ØÍøÂçµÄÎȹÌÐÔ£¬½ø¶øά³Ö±íÐ͵ÄÎÈ̬£¬ÎªÉîÈëÃ÷È··¢ÓýÇþµÀ»¯ÌØÕ÷µÄÒÅ´«»úÖÆÌṩÁËеÄÆôʾ¡£¡£¡£
ͼ1. ¹ûÓ¬microRNA½éµ¼µÄÇþ»¯µ÷¿ØÑо¿ÏµÍ³¡£¡£¡£Í¼ÖÐʾÒâºÚ¸¹¹ûÓ¬dicer-1ÇõÍƷϵ£¬ÔÚ¸ÃÒÅ´«Åä¾°ÖУ¬»ùÒò×éÖÐmicroRNAµÄ±í´ïˮƽ±»ÆÕ±éÇÒ΢ÈõµØϵ÷¡£¡£¡£
¸ÃÂÛÎÄ¡°Canalization of Phenotypes¡ªWhen the Transcriptome is Constantly but Weakly Perturbed¡±£¬ÓÚ2023Äê1ÔÂÔÚ½ø»¯ÒÅ´«Ñ§¹ú¼ÊÖ÷Á÷ÆÚ¿¯ Molecular Biology and Evolution½ÒÏþ¡£¡£¡£ngµç×ÓÓÎÏ·ÉúÃü¿ÆѧѧԺÊǵÚÒ»×÷Õßµ¥Î»¡£¡£¡£¸ÃÊÂÇéÊܵ½¹ú¼Ò×ÔÈ»¿Æѧ»ù½ð ¡¢¹ã¶«Ê¡×ÔÈ»¿Æѧ»ù½ð ¡¢Öйú²©Ê¿ºó»ù½ð ¡¢¹ã¶«Ê¡ÖصãÑз¢ÏîÄ¿ºÍÄÏ·½º£Ñó¿ÆѧÓ빤³Ì¹ã¶«Ê¡ÊµÑéÊÒ£¨Ö麣£©Á¢ÒìÍŶÓÏîÄ¿µÄ×ÊÖú¡£¡£¡£
ÂÛÎÄÁ´½Ó: https://academic.oup.com/mbe/article/40/1/msad005/6974681
µØµã:¹ãÖÝÊÐиÛÎ÷·135ºÅ Óʱà:510275
µç»°: 020-84112828
ngµç×ÓÓÎÏ·°æȨËùÓÐ COPYRIGHT?1999-2022 , SUN YAT-SEN UNIVERSITY