ngµç×ÓÓÎÏ·

05

¿ÆÑÐÏ£Íû

ÁèÎÄ»ªÍŶӷ¢Ã÷Ó붯ÂöÖàÑùÓ²»¯ÐÔÐÄѪ¹Ü¼²²¡Ïà¹ØµÄ³¦µÀ¾úȺ´úлÎï

¸å¼þȪԴ£º£º¹«¹²ÎÀÉúѧԺ ±à¼­£º£ºÖ£Áú·É¡¢¡¢¡¢Íõ¶¬Ã· ÉóºË£º£ºÏÄçø ÔĶÁÁ¿£º£º

ngµç×ÓÓÎÏ·ÐÂÎÅÍøÑ¶£¨Í¨Ñ¶Ô±Ñ¦àÚÁÁ£©¶¯ÂöÖàÑùÓ²»¯ÐÔÐÄѪ¹Ü¼²²¡£¨atherosclerotic cardiovascular diseases, ASCVD£©ÊÇÌìϹæÄ£ÄÚµ¼ÖÂéæÃüºÍ²Ð¼²µÄÖ÷ÒªÔ­Òò¡£ASCVDÊÇÒ»ÖÖ¶àÒòËØµ¼Öµļ²²¡£¬£¬£¬Ô½À´Ô½¶àµÄÑо¿Åú×¢£¬£¬£¬ÓªÑøÉÅʳºÍ³¦µÀ¾úȺ£¨gut microbiota£©Ï໥×÷ÓÃÔÚASCVDµÄ±¬·¢¿ªÕ¹ÖÐʩչÖ÷ÒªµÄµ÷¿Ø×÷Ó㬣¬£¬ÆäÖ㦵À΢ÉúÎïÑÜÉúµÄ´úлÎï±»ÒÔΪÊÇÓ°ÏìASCVDµÄ²¡ÀíÐÄÀíÀú³ÌµÄÒªº¦Çý¶¯ÒòËØ¡£È»¶ø£¬£¬£¬ÏêϸÊǺÎÖÖ³¦µÀ΢ÉúÎï´úлÎïʩչ×÷Óü°ÆäÓ°Ï춯ÂöÖàÑùÓ²»¯µÄ»úÖÆÉÐÓдý½øÒ»²½Ñо¿¡£

ngµç×ÓÓÎÏ·¹«¹²ÎÀÉúѧԺÁèÎÄ»ª½ÌÊÚÍŶÓÔÚÐÄѪ¹ÜÁìÓòµÄ¹ú¼Ê¶¥¼¶ÆÚ¿¯Circulation Research (IF=23.213)½ÒÏþÁËÌâΪ¡°Gut Microbially Produced Indole-3-Propionic Acid Inhibits Atherosclerosis by Promoting Reverse Cholesterol Transport and its Deficiency Is Causally Related to Atherosclerotic Cardiovascular Disease¡±µÄ·âÃæÂÛÎÄ¡£¸ÃÂÛÎÄÓɹ«¹²ÎÀÉúѧԺÁèÎÄ»ª½ÌÊÚÓëÑîÑà½ÌÊÚΪÅäºÏͨѶ×÷Õߣ¬£¬£¬²©Ê¿Ñо¿ÉúѦàÚÁÁºÍ³ÂÐñΪÅäºÏµÚÒ»×÷Õߣ¬£¬£¬ngµç×ÓÓÎÏ·×÷ΪµÚÒ»µ¥Î»¡£

¸ÃÑо¿Ê×ÏÈͨ¹ý²¡Àý±ÈÕÕÑо¿·¢Ã÷¹ÚÐIJ¡»¼Õß³¦µÀ¾úȺ´úлɫ°±Ëᱬ·¢ßÅßá-3-±ûËᣨIPA£©µÄÄÜÁ¦ÏÔÖø½µµÍ£¬£¬£¬·à±ãºÍѪÇåÖÐIPAˮƽÏÔÖøïÔÌ­¡£½øÒ»²½µÄ¶¯ÎïʵÑé·¢Ã÷£¬£¬£¬ÉÅʳÔö²¹IPA¿ÉÒÔ»º½âApoE-/-СÊó¶¯ÂöÖàÑùÓ²»¯µÄÏ£Íû£¬£¬£¬Ìá¸ß¶¯ÂöÖàÑù°ß¿éµÄÎȹÌÐÔ¡£»£»£»úÖÆÑо¿·¢Ã÷£¬£¬£¬IPAͨ¹ýз¢Ã÷µÄmiR-142-5p/ABCA1ÐźÅÖáÔö½ø¾ÞÊÉϸ°ûµ¨¹Ì´¼ÍâÁ÷£¬£¬£¬´Ó¶øÒÖÖÆÅÝĭϸ°ûµÄÐγÉ¡£¶øÌåÄÚIPAȱ·¦¿É¼ÓËÙApoE-/-СÊó¶¯ÂöÖàÑùÓ²»¯µÄÏ£Íû£¬£¬£¬²¢ÓëÈËȺASCVD·¢²¡·çÏÕÔöÌíÓÐÏÔÖø¹ØÁª¡£ÕâЩЧ¹ûΪԤ·À»ò¸ÄÉÆASCVDÌṩÁËеÄDZÔÚ¸ÉÔ¤°Ðµã¡£


EC95EC61200517AA3D49B2496F7_C6D30A13_81F3

ͼһ£º£º³¦µÀ¾úȺɫ°±Ëá´úлÎïßÅßá±ûËᣨIPA£©¿¹¶¯ÂöÖàÑùÓ²»¯×÷ÓõĻúÖÆ


¸ÃÑо¿Êܹú¼Ò×ÔÈ»¿ÆÑ§»ù½ðÖØµãÏîÄ¿£¨No. 81730090ºÍNo. 82030098£©µÄ×ÊÖú¡£

ÂÛÎÄÁ´½Ó£º£ºhttps://www.ahajournals.org/doi/10.1161/CIRCRESAHA.122.321253


¡¾ÍøÕ¾µØÍ¼¡¿