ngµç×ÓÓÎÏ·ÐÂÎÅÍøѶ£¨Í¨Ñ¶Ô±ÀîÔ£©¡¶ÖйúסÃñÓªÑøÓëÂýÐÔ²¡×´Ì¬±¨¸æ£¨2020Ä꣩¡·×îÐÂÊý¾ÝÏÔʾ£¬£¬ÎÒ¹úÁè¼ÝÒ»°ëµÄ³ÉÄêÈ˳¬ÖØ»ò·ÊÅÖ¡£¡£¡£¡£¡£ÖÚËùÖÜÖª£¬£¬·ÊÅÖ»á´øÀ´Ò»ÏµÁпµ½¡ÎÊÌ⣬£¬ÀýÈç¸ßѪѹ¡¢¡¢¡¢ÌÇÄò²¡ºÍ¸ß֬Ѫ֢µÈ£¬£¬·ÊÅÖ»¼Õß±¬·¢ÌÇÄò²¡µÄ·çÏÕÊÇ·Ç·ÊÅÖ»¼ÕßµÄ6±¶ÒÔÉÏ¡£¡£¡£¡£¡£¿ÉÊÇijЩ·ÊÅÖ»¼ÕßËƺõ½ÏÁ¿ÐÒÔË£¬£¬ËûÃÇÖ»ÊÇÌåÖؽÏÖØ£¬£¬ÑªÌÇ¡¢¡¢¡¢ÑªÖ¬¡¢¡¢¡¢ÑªÑ¹µÈ´úлָ±êÕý³££¬£¬ÕâÖÖÈËȺר¼ÒÃǼò³Æ¡°¸£ÓÑ¡±¡£¡£¡£¡£¡£¿ÉÊÇÒ²Óв¿·Ö»¼ÕߺܿìÏ£ÍûÖÁ·ÊÅֺϲ¢2ÐÍÌÇÄò²¡£¡£¡£¡£¡£¨ÌÇÓÑ£©¡£¡£¡£¡£¡£Õë¶ÔÕâ¸öÕ÷Ï󣬣¬ngµç×ÓÓÎÏ·Á¥ÊôµÚÈýÒ½ÔºÄÚÉø͸Óë´úл²¡Ñ§¿Æ³ÂÑàÃú½ÌÊÚÍŶӾ­ÓɶàÄêµÄÑо¿£¬£¬È¡µÃÁËÖØ´ó·¢Ã÷¡£¡£¡£¡£¡£

ÎÊÌâÒ»£ºÌåÖØÔöÌíÊÇÔõôÑÝÄð³ÉÌÇÄò²¡µÄÄØ£¿£¿£¿

ƾ֤½üÆÚ³ÂÑàÃú½ÌÊÚÍŶÓÁªºÏÁÙ´²ÃâÒßѧÖÐÐijÑÒ¸±Ñо¿Ô±ÔÚ¹ú¼ÊÃâÒßѧÁìÓò¸ßˮƽÔÓÖ¾Cellular & Molecular Immunology£¨IF£º11.53£©½ÒÏþµÄÔ­´´Ñо¿£¨ÂÛÎÄÎÊÌ⣺Bacteroides ovatus-mediated CD27^?MAIT cell activation is associated with obesity-related T2D progression£©£¬£¬´¿´âÐÔ·ÊÅÖÏ£ÍûΪÌÇÄò²¡µÄÖ÷ҪĻºóÍÆÊÖΪ³¦µÀ¾úȺ£¬£¬Í¬Ê±Õ¹ÏÖÁ˼ÓËÙÒȵº¦Âϸ°ûËðÉ˵ÄлúÖÆ¡£¡£¡£¡£¡£ÂÛÎÄÅäºÏµÚÒ»×÷ÕßΪÄÚÉø͸¿ÆÀîÔ¡¢¡¢¡¢ÑîÞÈ¡¢¡¢¡¢Íõ¬’²©Ê¿ºó£¬£¬ÁÙ´²ÃâÒßѧÖÐÐIJÌÅàºê¡¢¡¢¡¢ngµç×ÓÓÎÏ·ÑÛ¿ÆÖÐÐÄκÀ´½ÌÊÚΪÅäºÏͨѶ×÷Õß¡£¡£¡£¡£¡£

ÎÊÌâ¶þ£º·ÊÅÖ¼°ÌÇÄò²¡Ïà¹Ø²¢·¢Ö¢±¬·¢¿ªÕ¹µÄÔ­ÒòÊÇʲô£¿£¿£¿

³ÂÑàÃú½ÌÊÚÚ¹Ê͵½£¬£¬·ÊÅÖÒýÆðµÄÒȵºËØ·´¿¹ÊÇÌÇÄò²¡»¼²¡ÂʳÖÐøÅÊÉýµÄÖ÷ҪΣÏÕÒòËØ£¬£¬ÂýÐԵͶÈÑ×Ö¢ÔÚ·ÊÅÖ¼°ÌÇÄò²¡Ïà¹Ø²¢·¢Ö¢µÄ±¬·¢¿ªÕ¹ÖÐÆðÖ÷Òª×÷ÓÃ¡£¡£¡£¡£¡£Ñо¿ÏÔʾ£¬£¬³¦µÀ¾úȺÓë´úл²¡±£´æ»¥ÎªÒò¹û¹Øϵ£¬£¬·ÊÅÖÖ¢»¼Õߵij¦µÀͨ͸ÐÔÏÔÖøÔöÌí£¬£¬Ä³Ð©¡°Óк¦¡±Ï¸¾ú¿É´©¹ý³¦µÀÉÏƤÒÆ룬£¬Òý·¢»úÌåµÍ¶ÈÑ×Ö¢·´Ó³£¬£¬µ¼ÖÂÒȵº¦Âϸ°û¹¦Ð§ÆÆË𡢡¢¡¢ÑªÌÇÒì³£¡£¡£¡£¡£¡£Í¨¹ýÔö²¹¡°ÒæÉú¾ú¡±£¬£¬µ÷Àí³¦µÀ¾úȺÔÓÂÒ£¬£¬Ó°Ïì»úÌå´úл£¬£¬Ò²³ÉΪʱÏÂÈÈÃŵÄÊÝÉí·½Ê½Ö®Ò»¡£¡£¡£¡£¡£È»¶ø³¦µÀ¾úȺÖÖÀà·±¶à£¬£¬ÎÒÃǶÔÆäÏàʶʮ·ÖÓÐÏÞ£¬£¬¾¿¾¹ÄÄЩ¾úȺ¶Ô´úл¡°ÓÐÒ桱£¬£¬ÄÄЩ¶Ô´úл¡°Óк¦¡±£¬£¬ÔõÑù¸üÓÐÕë¶ÔÐÔµÄͨ¹ý¸ÉÔ¤Ìض¨³¦µÀ¾úȺÇý¶¯¼õÖØ£¬£¬´Ó¶ø¸ÄÉÆ»úÌå´úлÊÇÏÖÔÚ¹Ø×¢µÄÈÈÃÅ¡£¡£¡£¡£¡£

ÎÊÌâÈý:Ä»ºóÍÆÊÖÊÇÔõô¾¾³öÀ´µÄ£¿£¿£¿

³ÂÑàÃú½ÌÊÚÏòµ¼¼õÖØÁªºÏÍŶӽ¨ÉèÁËÄêËê¡¢¡¢¡¢ÐÔ±ðºÍÌåÖØÖ¸Êý(BMI)ÏàÆ¥ÅäµÄ·ÊÅÖ»¼ÕßÁÙ´²Ñо¿ÐÐÁУ¬£¬ÆäÖаüÀ¨31Ãû´¿´âÐÔ·ÊÅÖ»¼Õß(ObH×é)ºÍ33Ãû·ÊÅֺϲ¢2ÐÍÌÇÄò²¡»¼Õß(ObT2D×é)¡£¡£¡£¡£¡£ÁíÍâÈë×é24ÃûÌåÖØÕý³£µÄ×ÔÔ¸Õß(HC×é)×÷Ϊ±ÈÕÕ¡£¡£¡£¡£¡£Ñо¿ÍŶÓÊ×ÏÈͨ¹ýºê»ùÒò×é²âÐòÊÖÒÕ½ÏÁ¿ÕâÈý×éÈËȺѪҺÑù±¾£¬£¬·¢Ã÷Äâ¸Ë¾úÃÅƷòÔÚ¡°·ÊÅֺϲ¢ÌÇÄò²¡×顱µÄÍâÖÜѪÖÐÏÔÖøÔö¶à£¬£¬½øÒ»²½Ï¸·Ö¾úÖÖ£¬£¬·¢Ã÷ÂÑÐÎÄâ¸Ë¾ú(Bacteroides ovatus)Ʒò×î¸ß¡£¡£¡£¡£¡£ÏÖÔÚÒÑÖªÂÑÐÎÄâ¸Ë¾úΪһÖÖ³¦µÀ¹²Éú¾ú£¬£¬¶ø·ÊÅÖÈËȺѪҺÖеÄϸÃÜÅþÁ¬ÂÑ°×ZO-1Ïà½ÏÌåÖØÕý³£ÕßÒ²ÏÔÖøÉý¸ß£¬£¬ÌáÐÑ·ÊÅÖ»¼Õß¿ÉÄܱ£´æ²î±ð³Ì¶ÈµÄ³¦µÀÆÁÕÏËðÉË£¬£¬µ¼Ö¡°³¦Â©¡±ÒýÆðµÄ³¦¾úÒÆ룬£¬¶øÂÑÐÎÄâ¸Ë¾úÊǼÓÈëT2DM±¬·¢¿ªÕ¹µÄÒªº¦³¦µÀÒÆλ¾ú¡£¡£¡£¡£¡£

ͼ1 ·ÊÅֺϲ¢2ÐÍÌÇÄò²¡»¼Õß³¦µÀÒÆλÂÑÐÎÄâ¸Ë¾úÔö¶à

ºê»ùÒò×é²âÐò½ÏÁ¿Èý×éѪ½¬Ñù±¾ÖÐ΢ÉúÎï×é³É²î±ð£¬£¬Õ¹ÏÖ·ÊÅֺϲ¢2ÐÍÌÇÄò²¡£¡£¡£¡£¡£¨ObT2D£©»¼ÕßѪ½¬Ö㦵ÀÒÆλÂÑÐÎÄâ¸Ë¾úÌØÒìÐÔÔö¶à

Ϊ½øÒ»²½ÆÊÎöÂÑÐÎÄâ¸Ë¾ú¼ÓÈëT2DM·¢²¡µÄ»úÖÆ£¬£¬ÍŶÓËø¶¨ÁËÒ»ÖÖÓ볦µÀ¾úȺÇ×½üÏà¹ØµÄ¹ÌÓÐÀàTϸ°û¡ª¡ªÕ³Ä¤Ïà¹Øºã¶¨T£¨MAIT£©Ï¸°û¡£¡£¡£¡£¡£MAITϸ°û£¬£¬ÔÚÈËÌåÖÐÂþÑÜÆձ顢¡¢¡¢º¬Á¿¸»ºñ£¬£¬ÌØÒìÐÔʶ±ð΢ÉúÎïȪԴB×åάÉúËØ´úл²úÆ·£¬£¬ÇÒÄܸÐÖª¶àÖÖÑ×ÐÔÐźÅ£¬£¬ÔÚ¶àÖÖ¼²²¡ÖÐÊ©Õ¹Ö÷Òª×÷ÓÃ¡£¡£¡£¡£¡£Á÷ʽϸ°ûÆÊÎöÅú×¢£¬£¬Åãͬ·ÊÅÖÏ£ÍûΪ2ÐÍÌÇÄò²¡£¬£¬MAITϸ°ûÊýÄ¿Öð½¥Ï½µ£¬£¬¶øÑ×ÐÔÒò×ÓIL-17Éø͸ˮƽÖð½¥Éý¸ß¡£¡£¡£¡£¡£ÍŶӽøÒ»²½ÆÊÎöMAITϸ°ûÖÐDZÔÚÖ²¡ÐÔ¹¦Ð§ÑÇȺ£¬£¬·¢Ã÷CD27ÒõÐÔMAITÑÇȺÔÚ·ÊÅֺϲ¢2ÐÍÌÇÄò²¡×éÏÔÖøÉÏÉý£¬£¬ÆäÊýÄ¿ÓëÒȵº¦Âϸ°û¹¦Ð§ËðÉ˳̶ȳʸºÏà¹Ø£¬£¬ÌáÐѸÃÑÇȺ¿ÉÄܼÓÈë2ÐÍÌÇÄò²¡µÄ±¬·¢¿ªÕ¹¡£¡£¡£¡£¡£

ͼ2 ´¿´âÐÔ·ÊÅÖÏ£ÍûΪ2ÐÍÌÇÄò²¡Àú³ÌÖÐMAITϸ°û±íÐÍÏÔÖø¸Ä±ä

Á÷ʽϸ°ûÊõ¼ì²â¿µ½¡±ÈÕÕ£¨HC£©¡¢¡¢¡¢´¿´âÐÔ·ÊÅÖ£¨ObH£©¡¢¡¢¡¢·ÊÅֺϲ¢2ÐÍÌÇÄò²¡£¡£¡£¡£¡£¨ObT2D£©Èý×éÖÐÍâÖÜѪMAITϸ°û±ÈÀý£»£»£»ÒÔ¼°MAITϸ°ûÊÜPMAÓëionomycin´Ì¼¤ºóIL-17¡¢¡¢¡¢TNF-¦Á¡¢¡¢¡¢IFN-¦ÃÉø͸ˮƽ¡£¡£¡£¡£¡£

½ÓÏÂÀ´£¬£¬ÎªÑéÖ¤MAITϸ°ûÔÚObT2D»¼ÕßÖеÄÒ쳣ת±äÊÇ·ñÓëÂÑÐÎÄâ¸Ë¾úÓйØ£¬£¬ÍŶÓÓÖÓøÃϸ¾ú×÷ÓýÎïÌåÍâ´Ì¼¤ÍâÖÜѪMAITϸ°û£¬£¬·¢Ã÷¸Ãϸ¾ú¼òÖ±¿ÉÒÔÒýÆðCD27ÒõÐÔMAITϸ°ûÑÇȺº¬Á¿Ôö¶à£¬£¬Í¬Ê±Äܹ»´Ì¼¤MAITϸ°û±¬·¢IL-17£¬£¬²¢ÇÒÂÑÐÎÄâ¸Ë¾ú¶ÔMAITϸ°ûµÄ¼¤»îÊÇͨ¹ýTCRÒÀÀµÍ¾¾¶µÄ¡£¡£¡£¡£¡£

ͼ3 ÂÑÐÎÄâ¸Ë¾úµ¼ÖÂMAITϸ°ûÒì³£»£»£»î»¯ÓëÒȵº¦Âϸ°û¹¦Ð§ËðÉËÇ×½üÏà¹Ø

Á÷ʽϸ°ûÊõ¼ì²âHC¡¢¡¢¡¢ObH¡¢¡¢¡¢ObT2DÈý×éÖÐCD27? MAITÑÇȺ±ÈÀý£¬£¬¼°ÆäÓëÌÇ»¯ÑªºìÂÑ°×ˮƽ£¨HbA1c£©¡¢¡¢¡¢ÒȵºËØ·´¿¹Ö¸Êý£¨HOMA-IR£©¡¢¡¢¡¢Òȵº¦Âϸ°û¹¦Ð§Ö¸Êý£¨HOMA-¦Â£©Ïà¹ØÐÔÆÊÎö¡£¡£¡£¡£¡£ÂÑÐÎÄâ¸Ë¾úÌåÍâ´Ì¼¤MAITϸ°û£¬£¬ÒýÆðCD27? MAITÑÇȺº¬Á¿Ôö¶à¡¢¡¢¡¢Éø͸IL-17ˮƽÔö¸ß¡£¡£¡£¡£¡£

×ÛÉÏËùÊö£¬£¬±¾Ñо¿Í¨¹ý½ÏÁ¿Èý×é¼ÓÈëÕßµÄѪҺÑù±¾·¢Ã÷£ºÒ»ÖÖ³¦µÀȪԴµÄÂÑÐÎÄâ¸Ë¾ú£¬£¬ÔÚ¡°·ÊÅֺϲ¢2ÐÍÌÇÄò²¡×顱µÄ»¼ÕßѪҺÖи߱í´ï£¬£¬¸Ã¾ú¿É´Ì¼¤MAITϸ°ûÒì³£»£»£»î»¯£¬£¬Í¨¹ýÉø͸°×½éËØ17£¨IL-17£©£¬£¬Òý·¢»úÌåµÍ¶ÈÑ×Ö¢·´Ó³£¬£¬µ¼Ö¦Âϸ°ûÆÆËðºÍÒȵºËØ·´¿¹£¬£¬¼Ì¶øÓÕ·¢2ÐÍÌÇÄò²¡¡£¡£¡£¡£¡£

ʾÒâͼ£ºÂÑÐÎÄâ¸Ë¾úͨ¹ýÒýÆðMAITϸ°ûÒì³£»£»£»î»¯½éµ¼Òȵº¦Âϸ°û¹¦Ð§ËðÉË

´ËÇ°£¬£¬MAITϸ°ûÒÑÔÚСÊóÄ£×ÓÉϱ»Ö¤ÊµÓë·ÊÅÖÒýÆðµÄ2ÐÍÌÇÄò²¡ÓйØ£¬£¬±¾Ñо¿Ê¹ÓÃÁÙ´²Ñù±¾£¬£¬Ê״ν«Á½ÖÖÕ÷ÏóÁ¬Ïµ£¬£¬´Ó¡°³¦µÀ-ÃâÒß-´úл¡±ÖáµÄ½Ç¶ÈÆÊÎö´¿´âÐÔ·ÊÅÖÏ£ÍûΪ·ÊÅֺϲ¢2ÐÍÌÇÄò²¡µÄ·¢²¡»úÖÆ£¬£¬ÎªÔçÆÚÔ¤·ÀÌÇÄò²¡µÄ±¬·¢¿ªÕ¹ÌṩÐÂ˼Ð÷¡¢¡¢¡¢ÐÂÕ½ÂÔ¡£¡£¡£¡£¡£

ÎÊÌâËÄ£ºÎªÊ²Ã´²»ÊÇËùÓзÊÅÖ»¼Õ߶¼»áµÃÌÇÄò²¡£¡£¡£¡£¡£¿£¿£¿

³ÂÑàÃú½ÌÊÚ×ܽáµÀ£ºngµç×ÓÓÎÏ·Ñо¿ÊÂÇ鲿·ÖÚ¹ÊÍÁËΪʲôÓеĸ£ÓÑ»áÄð³ÉÌÇÓÑ£¬£¬¶øÓеÄÈ´²»»á¡£¡£¡£¡£¡£Ìض¨µÄ³¦µÀ¾úȺºÍÃâÒßϸ°û¹¦Ð§×´Ì¬Îª·ÊÅֺϲ¢2ÐÍÌÇÄò²¡µÄÏ£ÍûÌṩÁËÍⲿÌõ¼þ£¬£¬ÌáÐÑÎÒÃÇÐèÒª¾«×¼·À¿Ø¡¢¡¢¡¢¿ÆѧÖÎÀíÌåÖØ¡£¡£¡£¡£¡£

ngµç×ÓÓÎÏ·Á¥ÊôµÚÈýÒ½Ôº¼õÖØÁªºÏÍŶÓ£º

ngµç×ÓÓÎÏ·Á¥ÊôµÚÈýÒ½Ôº¼õÖØÁªºÏÍŶӽÓÄÉ¡°3+N¡±¶àѧ¿ÆÁªºÏ¾«×¼ÕïÁÆģʽÖÎÁÆ·ÊÅÖÖ¢¡£¡£¡£¡£¡£¡£¡£¡°3+N¡±ÕïÁÆģʽ¼´ÒÔÄÚÉø͸ѧ¿ÆΪÖ÷µ¼£¬£¬¡°3¡±´ú±íÔڹŰåµÄÓªÑø+Ô˶¯+ÐÄÀí¸ÉÔ¤µÄ»ù´¡ÉÏ£¬£¬ÁªºÏ½ÓÄÉ¡°N¡±Î÷Ò©¡¢¡¢¡¢ÖÐÒ½Ò©¡¢¡¢¡¢Õë¾Ä»òÕß΢´´¼õÖØÊÖÊõµÈÖÎÁÆÊֶΣ¬£¬³ä·ÖÑéÕ¹ÁªºÏÍŶÓÓÅÊÆ£¬£¬Îª»¼ÕßÌṩһվʽ·þÎñ¡£¡£¡£¡£¡£ÒÀÍÐҽԺǿʢµÄ×ÛºÏʵÁ¦£¬£¬ÕûºÏÓªÑø¿Æ¡¢¡¢¡¢¿µ¸´¿Æ¡¢¡¢¡¢¾«ÉñÐÄÀí¿Æ¡¢¡¢¡¢ÖÐÒ½Õë¾Ä¿Æ¼°Î¸³¦Íâ¿ÆµÈ¶àѧ¿ÆÓÅÊÆ×ÊÔ´£¬£¬ÖÐÎ÷Ò½Á¬Ïµ£¬£¬Îª»¼ÕßÖƶ©¿Æѧ¡¢¡¢¡¢ºÏÀí¡¢¡¢¡¢Çå¾²µÄ¸öÌ廯¼õÖØ·½°¸£¬£¬²¢ÇÒ½¨Éè¹æ·¶µÄËæ·Ã×·×Ùϵͳ¡£¡£¡£¡£¡£×Ô2020Ä꿪ÕïÒÔÀ´£¬£¬ÒÑÀÖ³ÉÕïÖÎǧÓàÃû·ÊÅÖ»¼Õߣ¬£¬×ÜÓÐÓÃÂʵִï80%ÒÔÉÏ£¬£¬ÐγÉÓÅÒìµÄÉç»áÆ·ÅÆ£¬£¬Îª¿í´ó»¼ÕßÌṩÓÅÖʵÄÒ½ÁÆ·þÎñ¡£¡£¡£¡£¡£

ÂÛÎÄÁ´½Ó£ºhttps://www.nature.com/articles/s41423-022-00871-4