ngµç×ÓÓÎÏ·

05

¿ÆÑÐÏ£Íû

ngµç×ÓÓÎÏ·2ÏîÑо¿ÈëÑ¡Öйú2021Äê¶ÈÖ÷ҪҽѧϣÍû

¸å¼þȪԴ£º£º£ºÖ×Áö·ÀÖÎÖÐÐÄ ±à¼­£º£º£ºÍõ¶¬Ã· ÔĶÁÁ¿£º£º£º

ngµç×ÓÓÎÏ·ÐÂÎÅÍøÑ¶£¨Í¨Ñ¶Ô±Âæ»Üåû¡¢¡¢³ÂÓêÅæ¡¢¡¢ÕÔÏÖÍ¢£©¿ËÈÕ£¬£¬£¬Öйúҽѧ¿ÆÑ§ÔºÔÚÖйúҽѧ¿ªÕ¹´ó»áÉÏÐû²¼ÁËÖйú2021Äê¶ÈÖ÷ҪҽѧϣÍû¡£¡£¡£ngµç×ÓÓÎÏ·Ö×Áö·ÀÖÎÖÐÐÄÐìÈ𻪽ÌÊÚÍŶÓ¡¢¡¢Âí¿¥½ÌÊÚÍŶÓǣͷµÄÑо¿ÈëÑ¡¡£¡£¡£ÆäÖУ¬£¬£¬ÁÙ´²Ò½Ñ§ÁìÓò¹²7Ï£¬£¬ngµç×ÓÓÎÏ·Õ¼2Ïî¡£¡£¡£

·¢Ã÷PD-1¿¹ÌåÁªºÏ»¯ÁÆ¿ÉÏÔÖøÑÓÉìÍíÆÚʳ¹ÜÁÛ°©»¼ÕßµÄÉúÑÄʱ¼ä

Ö÷ÒªÍê³Éµ¥Î»£º£º£ºngµç×ÓÓÎÏ·Ö×Áö·ÀÖÎÖÐÐĵÈ

Ö÷ÒªÍê³ÉÈË£º£º£ºÐìÈ𻪡¢¡¢Âæ»ÜåûµÈ¡£¡£¡£

Ñо¿À´ÓÉ£º£º£ºJAMA. 2021£º£º£º326(10):916-925

ʳ¹Ü°©ÊÇÒ»ÖÖÖйú¸ß·¢µÄÏû»¯µÀÖ×Áö£¬£¬£¬¾ÝÌìÏÂÎÀÉú×é֯ͳ¼Æ£¬£¬£¬ÎÒ¹úÿÄêз¢Ê³¹Ü°©²¡ÀýÊýºÍéæÃü²¡ÀýÊýռȫÇòÒ»°ëÒÔÉÏ¡£¡£¡£ÓëÎ÷·½¹ú¼ÒÒÔÏÙ°©ÎªÖ÷µÄ²¡ÀíÌØÕ÷²î±ð£¬£¬£¬ÎÒ¹ú95%ʳ¹Ü°©²¡ÀíÌåÏÖΪÁÛ×´ÉÏÆ¤Ï¸°û°©¡£¡£¡£ÍíÆÚʳ¹ÜÁÛ°©ÖÎÁÆÁÆÐ§²î£¬£¬£¬Ø½ÐèΪÖйúʳ¹Ü°©»¼Õß̽Ë÷¸üÓÐÓõÄÖÎÁÆÊֶΡ£¡£¡£

Ϊ´Ë£¬£¬£¬ÐìÈ𻪽ÌÊÚǣͷ¿ªÕ¹ÁËÒ»ÏîÆÀ¹À¿¨ÈðÀûÖéµ¥¿¹£¨PD-1¿¹Ì壩ÁªºÏ×Ïɼ´¼ÎÂ˳²¬£¨TP£©ÓÃÓÚÍíÆÚʳ¹ÜÁÛ°©Ò»ÏßÖÎÁƵÄËæ»ú¡¢¡¢Ë«Ã¤¡¢¡¢Î¿½å¼Á±ÈÕÕ¡¢¡¢¶àÖÐÐÄ¢óÆÚÁÙ´²Ñо¿ESCORT-1stÑо¿¡£¡£¡£Ñо¿Ð§¹ûÏÔʾ£¬£¬£¬Ïà±È»¯ÁÆ×飬£¬£¬PD-1¿¹ÌåÁªºÏ»¯ÁÆ×éÏÔÖø¸ÄÉÆÁË»¼ÕßµÄOS£¨15.3¸öÔÂvs.12.0¸öÔ£©£¬£¬£¬éæÃü·çÏÕÏÔÖøÏ½µÁË30%£¬£¬£¬PFSÒ²ÏÔÖøÑÓÉ죨6.9¸öÔÂvs.5.6¸öÔ£©£¬£¬£¬×ÜÓÐÓÃÂʸߴï72.1%£¨ÏÖÔÚ¹ú¼Ê×î¸ßÓÐÓÃÂÊ£©¡£¡£¡£¶ø»¼ÕßÇå¾²ÐÔ·½Ã棬£¬£¬PD-1¿¹Ìå+»¯ÁÆÓë±ÈÕÕ×éÏà±Èδ¼ûÏÔ×ÅÐÂÔö²»Á¼ÊÂÎñ£¬£¬£¬Á½×黼ÕßÉúÑÄÖÊÁ¿ÆÀ·ÖÏ൱¡£¡£¡£

ESCORT-1stÑо¿Ö¤ÊµÁË¿¨ÈðÀûÖéµ¥¿¹ÁªºÏTP·½°¸ÔÚÎÒ¹úÍíÆÚʳ¹ÜÁÛ°©»¼ÕßÖеÄ׿ԽÁÆÐ§ºÍÇå¾²ÐÔ£¬£¬£¬»ùÓÚESCORT-1stÑо¿£¬£¬£¬Öйú¹ú¼ÒÒ©Æ·¼àÊÓÖÎÀí¾Ö£¨NMPA£©Åú×¼¿¨ÈðÀûÖéµ¥¿¹ÁªºÏ×Ïɼ´¼ÎÂ˳²¬ÓÃÓÚ¾Ö²¿ÍíÆÚ/¸´·¢»ò×ªÒÆÐÔʳ¹ÜÁÛ°©»¼ÕßµÄÒ»ÏßÖÎÁÆ¡£¡£¡£

±ÇÑʰ©·Å»¯ÁƺóʹÓÿ¨ÅàËû±õ½Ú×໯ÁƸ¨ÖúÖÎÁƸÄÉÆ¾Ö²¿ÍíÆÚ±ÇÑʰ©»¼ÕßÉúÑÄÆÚ

Ö÷ÒªÍê³Éµ¥Î»£º£º£ºngµç×ÓÓÎÏ·Ö×Áö·ÀÖÎÖÐÐÄ¡¢¡¢ÖÐÄÏ´óÑ§ÏæÑÅÒ½Ôº¡¢¡¢»ªÖпƼ¼´óѧͬ¼ÃҽѧԺÁ¥ÊôЭºÍÒ½Ôº¡¢¡¢¹óÖÝÒ½¿Æ´óѧÁ¥ÊôÖ×ÁöÒ½Ôº¡¢¡¢¹ãÎ÷Ò½¿Æ´óѧÁ¥ÊôÖ×ÁöÒ½Ôº¡¢¡¢¿Õ¾ü¾üÒ½´óѧÎ÷¾©Ò½Ôº¡¢¡¢»ªÖпƼ¼´óѧͬ¼ÃҽѧԺÁ¥Êôͬ¼ÃÒ½ÔºµÈ¡£¡£¡£

Ö÷ÒªÍê³ÉÈË£º£º£ºÂí¿¥¡¢¡¢ËïÓ±¡¢¡¢Ð»·½ÔÆ¡¢¡¢ÌÆÁáçç¡¢¡¢³ÂÓêÅæ¡¢¡¢ÁõÐè¡¢¡¢ÖÜÇÙ¡¢¡¢ÑîÀ¤Óí¡¢¡¢½ð·ç¡¢¡¢ÖìС¶«¡¢¡¢Ê¯Ã·¡¢¡¢ºú¹úÇå¡¢¡¢ºúΰººµÈ¡£¡£¡£

Ñо¿À´ÓÉ£º£º£ºThe Lancet. 2021£»£»£»398£º£º£º303-313

±ÇÑʰ©¸ß·¢ÓÚÖйú£¬£¬£¬Äêз¢²¡ÀýռȫÇòÒ»°ë¡£¡£¡£·ÅÁƺóÍç¹ÌµÄÈ«ÉíϸС²ÐÁôÖ×ÁöÊÇÆäÖÎÁÆÊ§°ÜµÄȪԴ£¬£¬£¬¶øÓÉÓÚ·ÅÁƺó»¼ÕßÉíÌå״̬²î£¬£¬£¬ÄÑÒÔÄÍÊܼÈÍù¸ßÇ¿¶ÈµÄ¹Å°å»¯ÁÆ£¨Íê³ÉÂʽöÔ¼40%-50%£©£¬£¬£¬³ÉÎªÖÆÔ¼ÁÆÐ§Ìá¸ßµÄÆ¿¾±¡£¡£¡£

Âí¿¥Ñо¿ÍŶÓÌá³öÁËС¼ÁÁ¿¡¢¡¢³¤Ê±¼ä¿Ú·þϸ°û¶¾Ò©Î│ÅàËû±õµÄ½Ú×໯ÁÆÄ£Ê½£¬£¬£¬Æä¿Éͨ¹ýɱÉËÖ×Áö¸Éϸ°ûµÈ»úÖÆ³ÖÐøÒÖÖÆÖ×Áö£¬£¬£¬Í¬Ê±Ìá¸ß»úÌåÄÍÊÜÐÔ£¬£¬£¬²¢Í¨¹ýǣͷһÏî¶àÖÐÐÄ¡¢¡¢Ç°Õ°ÐÔÁÙ´²Ñо¿·¢Ã÷£¬£¬£¬ÔÚ·ÅÁƺóʹÓá°¿¨ÅàËû±õ½Ú×໯ÁÆ¡±¿É½«Ö×ÁöÏ£Íû·çÏÕÏÔÖø½µµÍ45%£¬£¬£¬ÇÒÑÏÖØ¶¾¸±×÷Óñ¬·¢ÂʽϹŰ廯ÁÆïÔÌ­ÁËÎå·ÖÖ®Èý£¬£¬£¬Íê³ÉÂÊ´ï74%¡£¡£¡£

¸ÃÑо¿Í»ÆÆÁ˹Ű廯ÁƵÄÁÆÐ§Æ¿¾±£¬£¬£¬²¢ÇÒ¸ÃģʽÀÏÒ©ÐÂÓ㬣¬£¬¿Ú·þÓÃÒ©Àû±ã¿É¼°£¬£¬£¬Ò×ÓÚÏòϲãÍÆ¹ã¡£¡£¡£¼ÓÄôó¶àÂ×¶à´óѧRobert Kerbel½ÌÊÚͬÆÚÊöÆÀÔÞÉÍ¡°¸Ã·Å»¯ÁÆÐÂģʽΪ»¼Õß´øÀ´ÁËÏÔÖøµÄÉúÑÄ»ñÒæ£¬£¬£¬Í¬Ê±½¨ÉèÁ˿ɻݼ°¿í´ó¿ªÕ¹Öйú¼Ò»¼ÕߵĿ¹°©Ä£Ê½¡±¡£¡£¡£Ñо¿Ò»¾­½ÒÏþ¼´¸ÄдÁ˹ú¼ÊͨÓõÄÃÀ¹úNCCNÖ¸ÄÏ£¬£¬£¬²¢ÈëÑ¡ÁËÖйú¿ÆÐ­2021Äê¶È¡°ÖйúÉúÃü¿ÆÑ§Ê®´óÏ£Íû¡±¡£¡£¡£

¾ÝÏàʶ£¬£¬£¬Öйú2021Äê¶ÈÖ÷ҪҽѧϣÍû¾Û½¹¸ÃÄê¶È±¬·¢µÄ¾ßÓÐÒ»¶¨Ñ§ÊõÓ°ÏìÁ¦¡¢¡¢Éç»áÓ°ÏìÁ¦ºÍÔö½øÑ§¿Æ¿ªÕ¹¡¢¡¢Ë¢Ð¡°´Ù·ÀÕï¿ØÖοµ¡±Êµ¼ù¡¢¡¢Íƶ¯¿µ½¡¹¤ÒµÇ°½øÇ±Á¦µÄҽѧ¿Æ¼¼Ï£Íû£¬£¬£¬åàÑ¡½ÓÄÉ¡°¶àÔª»¯¼ÆÁ¿Ö¸±ê¡±Óë¡°¶àÖ÷ÌåÑÐÅС±ÏàÁ¬ÏµµÄ·ÖÀàÆÀ¼Û·½Ê½£¬£¬£¬ÎÞÆ«ÒÐÄÉÈë¶àÔ´Êý¾Ý£¬£¬£¬°üÀ¨ÎÒ¹úÑо¿ÕßÔÚ2021Äê¶È½ÒÏþµÄҽѧÑо¿ÂÛÎÄ¡¢¡¢»ñÊÚȨµÄ¹ú¼ÊרÀû¡¢¡¢»ñÅúÉÏÊеĹú²úÒ©Îï²úÆ·¡¢¡¢Åú×¼×¢²áµÄ¹ú²úÁ¢ÒìÒ½ÁÆÆ÷е²úÆ·£¬£¬£¬ÍøÂç×ܼƶà´ï27.6ÍòÓàÌõÊý¾Ý×÷ΪåàÑ¡»ù´¡Êý¾Ý¡£¡£¡£Ñо¿ÍŶӾÙÐÐÁ¿»¯ÆÊÎö¡¢¡¢×¨¼ÒÆÀ¼ÛºÍ×ÛºÏÑÐÅУ¬£¬£¬ÐγÉ77¸ö±¸Ñ¡Ï£¬£¬¾­Ñ§²¿Î¯Ô±ÍƼö¡¢¡¢ÉóºËίԱ»áÉóºË¡¢¡¢Ö´Î¯»áÉ󶨣¬£¬£¬×îÖÕ±¬·¢31ÏîÄê¶ÈÖ÷ҪϣÍû¡£¡£¡£

ÎĸåÖÕÉ󣺣º£ºÖ×Áö·ÀÖÎÖÐÐÄ ÎÄÏòÑô

¡¾ÍøÕ¾µØÍ¼¡¿