ngµç×ÓÓÎÏ·

05

¿ÆÑÐÏ£Íû

»Æ»³ÒåÍŶÓÔÚÖ×Áö¹â´ß»¯ÖÎÁÆÑо¿ÁìÓòÈ¡µÃϵÁÐЧ¹û

¸å¼þȪԴ £ºÒ©Ñ§Ôº£¨ÉîÛÚ£© ±à¼­ £ºÖ£Áú·É¡¢¡¢¡¢Íõ¶¬Ã· ÔĶÁÁ¿ £º

ngµç×ÓÓÎÏ·ÐÂÎÅÍøÑ¶£¨Í¨Ñ¶Ô±»Æ»³Ò壩Ö×ÁöÊÇÄ¿½ñÎ £º¦ÈËÀàÉç»áµÄÖØ´ó¿µ½¡ÎÊÌ⣬£¬£¬¿ª·¢¸ßЧ¡¢¡¢¡¢µÍ¶¾µÄ¿¹Ö×ÁöÒ©Îï¾ßÓÐÖ÷ÒªµÄÑо¿ÒâÒåºÍÉç»á¼ÛÖµ¡£¡£¡£·¦Ñõ΢ÇéÐÎÊÇʵÌåÖ×ÁöµÄÏÔÖøÌØÕ÷£¬£¬£¬µ¼ÖÂÁÙ´²Ö×ÁöÄÑÒÔ¸ùÖΡ¢¡¢¡¢ÈÝÒ׸´·¢ºÍ×ªÒÆ¡£¡£¡£Ñо¿ÖÎÁÆ·¦ÑõÖ×ÁöµÄÐÂÐÍ¿¹Ö×ÁöÒ©Îï¼°Æä×÷ÓûúÖÆ£¬£¬£¬¾ßÓÐÖØ´óµÄÀíÂÛ¼°ÁÙ´²Ó¦ÓüÛÖµ¡£¡£¡£

½üÈýÄ꣬£¬£¬ngµç×ÓÓÎϷҩѧԺ£¨ÉîÛÚ£©»Æ»³Ò帱½ÌÊÚÑо¿ÍŶÓÔÚ½ðÊô¹âÃô¼ÁµÄ¹¹Ð§ÓÅ»¯¡¢¡¢¡¢¹â¶¯Á¦ÖÎÁÆÐ»úÖÆ¡¢¡¢¡¢ÌåÄÚºÍÌåÍ⿹Ö×Áö»îÐÔÑо¿·½Ãæ×öÁËϵͳÐԺͿª´´ÐÔµÄÑо¿ÊÂÇ飬£¬£¬È¡µÃÁ˽׶ÎÐÔµÄÑо¿Ð§¹û£¬£¬£¬ÕâЩǰÆÚ¿ªÕ¹µÄÊÂÇéϸÃÜÁ¬ÏµÒ©ÎïÑз¢ÁìÓòÃæÁÙµÄÖØ´óÎÊÌâºÍÌôÕ½£¬£¬£¬¾ßÓÐÖ÷ÒªµÄ»ù´¡Ñо¿¼ÛÖµºÍDZÔÚµÄÓ¦ÓÃÔ¶¾°¡£¡£¡£

Ê×ÏÈ£¬£¬£¬ÍŶÓÊ×´ÎÌá³ö·¦ÑõÖ×Áö¹â´ß»¯ÖÎÁÆÀíÂÛ¡£¡£¡£ÏßÁ£ÌåºôÎüÁ´ÊÇÄܹ»¸ÐÊÜÑõÆøÅ¨¶Èת±äµÄÃô¸Ðϸ°ûÆ÷£¬£¬£¬²¢Í¨¹ýÏßÁ£ÌåºôÎüÁ´µ÷¿Ø·¦ÑõÓÕµ¼Òò×ӵıí´ïÒÔÔö½øÖ×Áö˳Ӧ·¦ÑõÇéÐΡ£¡£¡£Í¨¹ýÉè¼ÆÏßÁ£Ìå°ÐÏò½ðÊô¹âÃô¼Á£¬£¬£¬Ê¹ÓÃÒ¿¹âÃô¼ÁµÄ΢Ãë¼¶³¤Òý·¢Ì¬ÊÙÃüºÍÒý·¢Ì¬¸ßÑõ»¯»¹Ô­µç룬£¬£¬»ùÓڵͺÄÑõµÄ¹âÖµç×Ó×ªÒÆ»úÖÆ£¬£¬£¬ÔÚ³£ÑõºÍ·¦ÑõÇéÐÎϾùʵÏÖ¶ÔÏßÁ£ÌåºôÎüÁ´µç×Ó¹©Ì壬£¬£¬»¹Ô­Ì¬ÑÌõ£°·ÏÙàÑßʶþºËÜÕËᣨNADH£©µÄ¸ßЧ¹â´ß»¯Ñõ»¯£¬£¬£¬½ø¶øÆÆËðÏßÁ£Ìåµç×Óת´ïÁ´Õý³£ÐÄÀí¹¦Ð§£¬£¬£¬Ö×Áö·¦ÑõÓÕµ¼Òò×ÓµÄÎÞ·¨Ë³Ëì±í´ï£¬£¬£¬Ö×Áöϸ°ûÄÚÑõ»¯»¹Ô­Ê§ºâ²¢ÓÕµ¼Ö×ÁöÃâÒßÔ­ÐÔϸ°ûéæÃü£¨Í¼1£©¡£¡£¡£ÕâÏîÑо¿Îª¿ª·¢ÖÎÁÆ·¦ÑõÖ×ÁöµÄÐÂÐ͹âÃô¼Á£¬£¬£¬ÌṩÁËп´·¨ºÍÐÂÒªÁ죬£¬£¬¸ÃЧ¹ûÒÔ¡°Targeted photoredox catalysis in cancer cells¡±ÎªÌâ½ÒÏþÓÚ»¯Ñ§¶¥¼¶ÆÚ¿¯Nature Chemistry£¨2019£¬£¬£¬11£¬£¬£¬1041£¬£¬£¬IF = 24.4£¬£¬£¬SCI¸ß±»ÒýÂÛÎÄ£©£¬£¬£¬ngµç×ÓÓÎϷҩѧԺ£¨ÉîÛÚ£©»Æ»³Ò帱½ÌÊÚºÍÓ¡¶ÈÀí¹¤Ñ§ÔºSamya BanerjeeÖúÀí½ÌÊÚΪÂÛÎĵÄÅäºÏµÚÒ»×÷Õߣ¬£¬£¬Ó¢¹ú»ªÍþ´óѧPeter Sadler½ÌÊÚ¡¢¡¢¡¢·¨¹ú°ÍÀèÎÄÀíÑо¿´óѧGilles Gasser½ÌÊÚºÍngµç×ÓÓÎÏ·»¯Ñ§Ñ§Ôº³²êͽÌÊÚΪÂÛÎĵÄÅäºÏͨѶ×÷Õߣ¬£¬£¬ngµç×ÓÓÎϷΪ¸ÃЧ¹ûµÚÒ»Íê³Éµ¥Î»¡£¡£¡£

Ê×Ò³|ngµç×ÓÓÎÏ·Öйú¼¯ÍŹٷ½ÍøÕ¾

ͼ1. ·¦ÑõÖ×ÁöÏßÁ£Ìå°ÐÏòÒ¿¹âÃô¼ÁÓÃÓÚNADH¹â´ß»¯Ñõ»¯ÖÎÁÆ

¹Å°åµÄÒ¿¹âÃô¼ÁÔڿɼû¹âÇøÓòÎüÊÕÐÔÄܽϲî¡¢¡¢¡¢Ö¬ÈÜÐԸߡ¢¡¢¡¢ÏßÁ£Ìå°ÐÏòÐÔÇ¿µ¼ÖÂϸ°û°µ¶¾ÐԸߵÈȱÏÝ¡£¡£¡£ÍŶÓͨ¹ýϵͳµÄ¹¹Ð§¹ØÏµÑо¿£¬£¬£¬Á¢ÒìÐÔµØÒýÈë¾ßÓÐÇ¿¹âÎüÊÕÐÔÄܵÄÏã¶¹ËØ»ùÍźÍË®ÈÜÐԵļ¾ï§ÑλùÍÅ£¬£¬£¬»ñµÃ¹âÎüÊÕÐÔÄÜÓÅÒì¡¢¡¢¡¢°ÐÏòÖ×Áöϸ°ûÈÜøÌåµÄÐÂÐÍÒ¿¹âÃô¼Á£¬£¬£¬¾ßÓм«µÍµÄϸ°û°µ¶¾ÐÔºÍÓÅÒìµÄÉúÎïÏàÈÝÐÔ£¬£¬£¬¶ÔÌåÍâ×÷ÓýµÄÄÍË÷À­·ÇÄá¸Î°©Ï¸°ûºÍƤϺÉÁöСÊó¾ùÌåÏÖ³öÓÅÒìµÄ¹â´ß»¯ÖÎÁÆ»îÐÔ¡£¡£¡£ÕâÏîÊÂÇéΪÉè¼ÆºÍ¿ª·¢¸ßЧ¡¢¡¢¡¢µÍ¶¾µÄ½ðÊô¹âÃô¼ÁµÄÌṩÁËеÄÑо¿Ë¼Ð÷£¨Í¼2£©¡£¡£¡£ÕâÏîÑо¿Ð§¹ûÒÔ¡°In-vitro and In-vivo Photocatalytic Cancer Therapy with Biocompatible Iridium(III) Photocatalysts¡±ÎªÌâ½ÒÏþÓÚ»¯Ñ§¶¥¼¶¿¯ÎïAngewandte Chemie International Edition £¨2021£¬£¬£¬60£¬£¬£¬9474£¬£¬£¬ÈÈÃÅÂÛÎÄ£¬£¬£¬IF = 15.3£©¡£¡£¡£ngµç×ÓÓÎϷҩѧԺ£¨ÉîÛÚ£©Ñо¿Éú»Æ²ÓΪÂÛÎĵĵÚÒ»×÷Õߣ¬£¬£¬»Æ»³Ò帱½ÌÊÚΪÂÛÎÄΨһͨѶ×÷Õߣ¬£¬£¬ngµç×ÓÓÎϷΪ¸ÃЧ¹ûµÚÒ»Íê³Éµ¥Î»¡£¡£¡£

Ê×Ò³|ngµç×ÓÓÎÏ·Öйú¼¯ÍŹٷ½ÍøÕ¾

ͼ2. Ç¿¹âÎüÊÕ¡¢¡¢¡¢¸ßÉúÎïÏàÈÝÐÔÒ¿¹âÃô¼ÁÓÃÓÚÖ×Áö¹â´ß»¯ÖÎÁÆ

Ö×ÁöÒìÖÊÐÔÓë¶àÒ©ÄÍÒ©ÐÔÊÇÁÙ´²Ö×ÁöÖÎÁƵÄÄѵ㣬£¬£¬Êǵ¼ÖÂÁÙ´²Ö×ÁöÖÎÁÆÊ§°ÜºÍ¸´·¢µÄÖ÷ÒªÔ­Òò¡£¡£¡£¿ËÈÕ£¬£¬£¬¸ÃÍŶÓÊ×´ÎÔÚµ¥Ï¸°ûÌõÀí̽ÌÖÁËսʤÖ×ÁöÒìÖÊÐԵĽðÊôÒ©ÎïÉè¼ÆÕ½ÂÔ¡£¡£¡£»ùÓÚµ¥Ï¸°ûµç¸ÐñîºÏµÈÀë×ÓÌåÖÊÆ×£¨ICP-MS£©ÊÖÒÕ£¬£¬£¬Ñо¿·¢Ã÷Ïà±Èµ¥ºËÒ¿ÅäºÏÎ£¬£¬Ë«ºËÒ¿ÅäºÏÎïµÄϸ°ûÉãÈ¡ºÍ°ûÄÚÖÍÁôЧÂÊÏÔÖøÌá¸ß¡£¡£¡£±ðµÄ£¬£¬£¬Ë«ºËÒ¿ÅäºÏÎïµÄÒý·¢²¨³¤ÏÔÖøºìÒÆ¡¢¡¢¡¢ÈýÖØÒý·¢Ì¬ÊÙÃüÑÓÉì¡¢¡¢¡¢NADH¹â´ß»¯ÐÔÏÔÖøÔöÇ¿£¬£¬£¬ÔÚ525ÄÉÃ×Â̹âÕÕÉäÏ£¬£¬£¬ÌåÏÖ³öÓÅÒìµÄÖ×Áö¹â´ß»¯ÖÎÁÆ»îÐÔ£¨Í¼3£©¡£¡£¡£ÕâÏîÊÂÇ鿪´´ÐÔµØÔÚµ¥Ï¸°û²ãÃæÕ¹ÏÖ¶àºË½ðÊôÅäºÏÎïÔÚսʤÖ×ÁöÒìÖÊÐԺͶàÒ©ÄÍÒ©ÐÔÎÊÌâµÄÏÔÖøÓÅÊÆ£¬£¬£¬¶Ô¿ª·¢ÖÎÁÆÄÍÒ©ÐÔÖ×ÁöµÄÐÂÐͽðÊôÅäºÏÎïÌṩÁËеÄÀíÂÛºÍÑо¿Êµ¼ù¡£¡£¡£¿ËÈÕ£¬£¬£¬¸ÃЧ¹ûÒÔ¡°Single-Cell Quantification of a Highly Biocompatible Dinuclear Iridium(III) Complex for Photocatalytic Cancer Therapy¡±ÎªÌâ½ÒÏþÓÚ»¯Ñ§¶¥¼¶¿¯ÎïAngewandte Chemie International Edition£¨2022£¬£¬£¬DOI: 10.1002/anie.202202098£¬£¬£¬IF = 15.3£©¡£¡£¡£ngµç×ÓÓÎϷҩѧԺ£¨ÉîÛÚ£©Ñо¿Éú·¶ÖÐÏÍΪÂÛÎĵĵÚÒ»×÷Õߣ¬£¬£¬»Æ»³Ò帱½ÌÊÚºÍÓ¡¶ÈÀí¹¤Ñ§ÔºSamya BanerjeeÖúÀí½ÌÊÚΪÂÛÎÄÅäºÏͨѶ×÷Õߣ¬£¬£¬ngµç×ÓÓÎϷΪ¸ÃЧ¹ûµÚÒ»Íê³Éµ¥Î»¡£¡£¡£

Ê×Ò³|ngµç×ÓÓÎÏ·Öйú¼¯ÍŹٷ½ÍøÕ¾

ͼ3. Ë«ºËÒ¿ÅäºÏÎïÓÃÓÚսʤÖ×ÁöÒìÖÊÐÔºÍÖ×Áö¹â´ß»¯ÖÎÁÆ

»ùÓÚÍŶÓÔÚÖ×Áö¹âÖÎÁÆÁìÓòµÄÑо¿Ð¢Ë³£¬£¬£¬»Æ»³Ò帱½ÌÊÚÊÜÑûÒÔͨѶ×÷ÕßÉí·Ý׫д¹â»î»¯½ðÊô¿¹Ö×ÁöÒ©ÎïÑо¿Ï£ÍûµÄ×ÛÊöÂÛÎÄ£¬£¬£¬ÒÔ¡°New Designs for Phototherapeutic Transition Metal Complexes¡±ÎªÌâ½ÒÏþÓÚ»¯Ñ§¶¥¼¶¿¯ÎïAngewandte Chemie International Edition£¨2020£¬£¬£¬59£¬£¬£¬61£¬£¬£¬IF = 15.3£¬£¬£¬¸ß±»ÒýÂÛÎÄ£©£¬£¬£¬ngµç×ÓÓÎϷΪÂÛÎĵڶþÍê³Éµ¥Î»¡£¡£¡£±ðµÄ£¬£¬£¬»Æ»³Ò帱½ÌÊÚÒÔͨѶ×÷ÕßÉí·Ý׫дϸ°ûÆ÷°ÐÏò½ðÊôÅäºÏÎïµÄ×ÛÊöÂÛÎÄ£¬£¬£¬ÒÔ¡°Recent advances in endoplasmic reticulum targeting metal complexes¡±ÎªÌâ½ÒÏþÓÚ»¯Ñ§¶¥¼¶×ÛÊöÆÚ¿¯Coordination Chemistry Reviews £¨2020£¬£¬£¬408£¬£¬£¬213178£¬£¬£¬IF = 22.3£©£¬£¬£¬ngµç×ÓÓÎϷҩѧԺ£¨ÉîÛÚ£©Ñо¿Éú»Æ²ÓΪÂÛÎĵĵÚÒ»×÷Õߣ¬£¬£¬ngµç×ÓÓÎϷΪÂÛÎĵÚÒ»Íê³Éµ¥Î»¡£¡£¡£

ÏîÄ¿ÍŶÓÒÀÍÐngµç×ÓÓÎϷҩѧԺ£¨ÉîÛÚ£©½¨ÉèÏȽøµÄ¸ßͨÁ¿¹âÃô»¯Ò©Îïɸѡƽ̨£¬£¬£¬ÖÂÁ¦ÓÚ·¢Ã÷Ö×Áö¹â´ß»¯ÖÎÁƺÍÖ×Áö°ÐÏòÒ©ÎïµÝË͵ÄÐÂÒªÁìºÍлúÖÆ£¬£¬£¬²¢»ùÓÚ¶à×éѧƽ̨¿ªÕ¹Ö×Áö¹â´ß»¯ÖÎÁƵĻúÖÆÑо¿¡£¡£¡£Í¬Ê±£¬£¬£¬ÍŶÓÒ²Õý¿ªÕ¹ë®´ú½ðÊôÒ©ÎïºÍÈËÔ´ÍâÃÚÌåÒ©ÎïµÝËÍÔØÌåÖÆ±¸ºÍÓ¦ÓÃÑо¿¡£¡£¡£

Ïà¹ØÂÛÎÄÁ´½Ó £º

1. https://www.nature.com/articles/s41557-019-0328-4

2. https://onlinelibrary.wiley.com/doi/abs/10.1002/ange.202015671

3. https://onlinelibrary.wiley.com/doi/abs/10.1002/anie.202202098

4. https://onlinelibrary.wiley.com/doi/10.1002/anie.201905171

5. https://www.sciencedirect.com/science/article/abs/pii/S0010854519305478

¡¾ÍøÕ¾µØÍ¼¡¿