ngµç×ÓÓÎÏ·

05

¿ÆÑÐÏ£Íû

׿ҵºè¡¢ËÕÎÄÈçÍŶӷ¢Ã÷¸»º¬miR-21a-5pÍâÃÚÌå±£»£»£»¤ÊÓÍøÄ¤Éñ¾­Ï¸°ûËðÉË

¸å¼þȪԴ£º£ºÖÐɽÑÛ¿ÆÖÐÐÄ ±à¼­£º£ºÖ£Áú·É¡¢Íõ¶¬Ã· ÔĶÁÁ¿£º£º

ngµç×ÓÓÎÏ·ÐÂÎÅÍøÑ¶£¨Í¨Ñ¶Ô±ËÕÎÄÈ磩Éñ¾­ÖÂäÐÔÑÛ²¡¾ßÓв»¿ÉÄæÐÔºÍÖÂäÂʸߵÄÌØµã £¬¸ø»¼Õß¡¢¼ÒÍ¥ºÍÉç»á´øÀ´ÑÏÖØµÄÓ°Ïì £¬Ò»Ö±ÊÇØ½´ý½â¾öµÄÌìÏÂÐÔÄÑÌâ¡£¡£¡£È±Ñª¡¢È±ÑõºÍÑ×Ö¢µÈ¶àÖÖÒòËØÔì³ÉÊÓÍøÄ¤Éñ¾­Ï¸°ûµÄ²»¿ÉÄæËðÉË¡£¡£¡£ËäÈ»ÒÑÓдó×ÚÑо¿ÊµÑéѰÕÒÓÐÓõÄÖÎÁÆ £¬µ«Ç±ÔÚµÄÉñ¾­±£»£»£»¤Ò©ÎïÔÚ¢ò/¢óÆÚÁÙ´²ÊÔÑéÖÐЧ¹û¾ù²»²ÇÏë £¬ÈÔ²»¿É×èÖ¹»òÄæ×ªÉñ¾­ËðÉË £¬×èÖ¹ÏÖÔÚ £¬ÈÔȻȱÉÙÇå¾²ÓÐÓõÄÖÎÁÆÒªÁì £¬Ø½´ý×·ÇóеÄÖÎÁÆË¼Ð÷¡£¡£¡£ngµç×ÓÓÎÏ·ÖÐɽÑÛ¿ÆÖÐÐÄ׿ҵºè¡¢ËÕÎÄÈç½ÌÊÚÍŶӷ¢Ã÷¸»º¬miR-21a-5pÍâÃÚÌå±£»£»£»¤ÊÓÍøÄ¤Éñ¾­Ï¸°ûËðÉË £¬ÎªÊÓÍøÄ¤Éñ¾­ËðÉËÖÎÁÆÌṩÁËеÄÖÎÁÆÆ«Ïò £¬²¢ÎªMSCȪԴµÄÍâÃÚÌåÔÚÉñ¾­ÖÂäÐÔÑÛ²¡µÄÁÙ´²×ª»¯ÌṩÁË¿ÆÑ§ÒÀ¾ÝºÍ»ù´¡¡£¡£¡£

3ÔÂ25ÈÕ £¬ngµç×ÓÓÎÏ·ÖÐɽÑÛ¿ÆÖÐÐÄ׿ҵºè½ÌÊÚÍŶÓÔÚ¹ú¼ÊÖøÃûÆÚ¿¯BiomaterialsÔÓÖ¾ÉÏÒÔResearch articleÐÎʽ½ÒÏþÌâΪ¡°TNF-¦Á stimulation enhances the neuroprotective effects of gingival MSCs derived exosomes in retinal ischemia-reperfusion injury via the MEG3/miR-21a-5p axis¡±µÄÂÛÎÄ £¬Ñо¿·¢Ã÷¼ä³äÖʸÉϸ°ûȪԴµÄÍâÃÚÌ帻º¬miR-21a-5pÄܹ»±£»£»£»¤ÊÓÍøÄ¤Éñ¾­Ï¸°ûËðÉË £¬²¢ÇÒÊ״η¢Ã÷TNF-¦ÁÔ¤´¦Àí¸Éϸ°û¿ÉÔöÇ¿ÆäÍâÃÚÌåµÄÉñ¾­±£»£»£»¤×÷Óà £¬Îª¸ÉÔ¤ÊÓÍøÄ¤Éñ¾­Ï¸°ûËðÉËÌṩеÄÖÎÁÆÕ½ÂÔ £¬²¢ÇÒÌá³öÁËÒ»ÖÖÔöÇ¿ÍâÃÚÌåÁÆÐ§µÄ·½°¸¡£¡£¡£

¼ä³äÖʸÉϸ°û£¨Mesenchymal stromal cells, MSC£©ÊÇÒ»ÖÖÂþÑÜÆÕ±éµÄ¶àDZÐÑĿϸ°û £¬¾ß±¸ÃâÒßµ÷Àí¡¢Î¢ÇéÐε÷¿ØºÍËðÉ˺óÐÞ¸´µÈ¡£¡£¡£¼ÈÍùÑо¿ÒÑ֤ʵMSC¿ÉÓÐÓÃÖÎÁƶàÖÖ¼²²¡ £¬µ«MSCÖÎÁÆÇ±ÔÚµÄÇå¾²ÎÊÌâµÈÒÀÈ»×èÈÅÆäÔÚÁÙ´²ÉÏÆÕ±éʹÓᣡ£¡£

MSC¿Éͨ¹ýÅÔÉøÍ¸»úÖÆÊ©Õ¹ÃâÒßµ÷¿Ø×÷Óà £¬ÆäÖÐMSCȪԴµÄÍâÃÚÌå×÷ΪһÖÖMSCÉøÍ¸µÄÑÇϸ°ûÒòËØ £¬¿ÉÒÔ×÷ΪMSCµÄÅÔÉøÍ¸Òò×ÓÀ´Ê©Õ¹ÉúÎïѧЧӦ £¬Îª½øÒ»²½ÊµÏÖÎÞϸ°ûÖÎÁÆ£¨ cell-free therapy £©ÌṩÁËеÄʵÏÖ;¾¶¡£¡£¡£ÍâÃÚÌåÊÇÓÉϸ°ûÄÚ¶àÅÝÌåÓëϸ°ûĤÈÚºÏºó £¬Êͷŵ½Ï¸°ûÍâ»ùÖÊÖеÄĤÐÔÄÒÅÝ £¬Ö±¾¶Îª30-150nm¡£¡£¡£ÆäÄÚº¬ÓÐÂѰס¢mRNAºÍmiRNAµÈÎïÖÊ £¬ÆÕ±é¼ÓÈëϸ°ûÖ®¼äµÄ½»Á÷¡£¡£¡£¸ÃÑо¿ÊÂÇ齫MSCȪԴµÄÍâÃÚÌ壨G-exo£©¾­²£Á§ÌåÇ»×¢Éä £¬Ó¦ÓÃÓÚÊÓÍøÄ¤ËðÉ˵ÄÖÎÁÆ £¬·¢Ã÷¿ÉÒÔµ÷ÀíÃâÒßÑ×Ö¢·´Ó³ £¬±£»£»£»¤ÊÓÍøÄ¤Éñ¾­½Úϸ°û£¨Retinal ganglion cell £¬RGC£©ËðÉË¡£¡£¡£²¢ÇÒÊ״η¢Ã÷TNF-¦Á Ô¤´Ì¼¤ºó £¬¿ÉÔöÇ¿MSCȪԴµÄG-exo£¨TG-exo£©µÄ±£»£»£»¤×÷Óᣡ£¡£

Ê×Ò³|ngµç×ÓÓÎÏ·Öйú¼¯ÍŹٷ½ÍøÕ¾

ͼ1. TG-exo¿É¼õÇáÊÓÍøÄ¤È±ÑªÔÙ¹à×¢ËùÖÂRGCµòÍöËðÉË

ÔÚÌåÄÚºÍÌåÍâÄ£×ÓÖÐ £¬½øÒ»²½·¢Ã÷G-exoÄÚ¸»º¬µÄmiRNA-21-5p¾ù¿É±£»£»£»¤RGCËðÉË £¬²¢ÒÖÖÆÐ¡½ºÖÊϸ°û¼¤»î¡£¡£¡£

Ê×Ò³|ngµç×ÓÓÎÏ·Öйú¼¯ÍŹٷ½ÍøÕ¾

ͼ2. TG-exoÄÚµÄmiR-21-5p½éµ¼Á˶ÔÊÓÍøÄ¤ËðÉ˱£»£»£»¤×÷ÓÃ

½øÒ»²½Ñо¿Ö°Ô±Ô¤²â²¢ÑéÖ¤ÁËmiRNA-21-5pµÄÉÏÓÎMEG3ºÍÏÂÓΰÐÂѰ×PDCD4¡£¡£¡£Í¨¹ý˫ӫ¹âËØÃ¸±¨¸æ»ùÒò²â¶¨ºÍ¹¦Ð§È±Ê§Ñо¿µÈÏà¹ØÊµÑé £¬Ö¤ÊµMEG3/miRNA-21-5p/PDCD4ÐźÅÖá½éµ¼ÁËTG-exo¶ÔÊÓÍøÄ¤ËðÉ˵ÄÉñ¾­±£»£»£»¤×÷Óᣡ£¡£

Ê×Ò³|ngµç×ÓÓÎÏ·Öйú¼¯ÍŹٷ½ÍøÕ¾

ͼ3. TG-exoÄÚµÄmiR-21-5p½éµ¼ÁËÑ×Ö¢ÒÖÖÆºÍ¶ÔRGCµÄ±£»£»£»¤×÷ÓÃ

¸ÃÏîÄ¿Ñо¿»ñµÃÁ˹ú¼ÒÖØµãÑз¢ÍýÏëºÍ¹ú¼Ò×ÔÈ»¿ÆÑ§»ù½ðÖ§³Ö¡£¡£¡£ngµç×ÓÓÎÏ·ÖÐɽÑÛ¿ÆÖÐÐÄ¡¢ÑÛ¿ÆÑ§¹ú¼ÒÖØµãʵÑéÊÒΪµÚÒ»µ¥Î» £¬ÓÝ×ÓîÚ²©Ê¿ÊDZ¾ÂÛÎĵĵÚÒ»×÷Õß £¬×¿Òµºè½ÌÊÚ¡¢ËÕÎÄÈç½ÌÊÚºÍÖìÓ±æÃÒ½ÉúÊDZ¾ÂÛÎÄͨѶ×÷Õß¡£¡£¡£

ÂÛÎÄÁ´½Ó£º£ºhttps://www.sciencedirect.com/science/article/pii/S0142961222001235#ack0010

¡¾ÍøÕ¾µØÍ¼¡¿