ngµç×ÓÓÎÏ·

05

¿ÆÑÐÏ£Íû

Á¥Êô¿ÚǻҽԺģʽÉúÎïÑо¿ÍŶÓÕ¹ÏÖ°©Ï¸°û¼ò»¯×ÔÉí»ùÒò×éÈßÓàÐòÁÐÒÔ±ã¿ìËÙÔöÖ³

¸å¼þȪԴ£º£ºÁ¥Êô¿ÚǻҽԺ | ×÷Õߣº£ºÐí±¦É½ ÔĶÁÁ¿£º£º

½üÆÚ £¬Á¥Êô¿ÚǻҽԺÐí±¦É½¸±Ñо¿Ô±ÓëÃÀ¹ú˹ÍÐÎÖ˹ҽѧÑо¿Ëù£¨Stowers Institute for Medical Research£©µÄJennifer L. Gerton½ÌÊÚÔÚ¡¶PLoS Genetics¡·£¨Ó°ÏìÒò×Ó6.100£©ÔÓÖ¾ÏàÖú½ÒÏþÑо¿ÂÛÎÄ £¬Õ¹ÏÖ°©Ï¸°û¿É¡°È¥·±´Ó¼ò¡±»ùÒò×éÖÐÈßÓàµÄºËÌÇÌåDNAÖØ¸´ÐòÁÐÀ´µÖ´ï¿ìËÙÔöÖ³µÄÄ¿µÄ£¨ÎÄÕÂÁ´½Ó£º£ºhttp://journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.1006771£©¡£¡£ÎÄÕ¿¯³ö £¬¼´Êܵ½¡°The Scientist¡±¡¢¡¢¡¢¡°ScienceDaily¡±¡¢¡¢¡¢¡°ÉúÎïͨ¡±¡¢¡¢¡¢¡°ËѺü¿Æ¼¼¡±¡¢¡¢¡¢¡°Ò׿ÆÑ§¡±¡¢¡¢¡¢¡°²âÐòÖйú¡±µÈº£ÄÚÍâ¿Æ¼¼ÐÂÎÅÍøÕ¾µÄÆÕ±é¹Ø×¢¡£¡£

ºËÌÇÌåDNA±àÂëºËÌÇÌåµÄÒªº¦×é·Ö-ºËÌÇÌåRNA £¬¶ÔÂѰ×ÖÊ·­ÒëºÍϸ°ûÔöÖ³¾ßÓÐÖ÷ÒªµÄ×÷Óᣡ£È»¶ø £¬ºËÌÇÌåDNAµÄ¿½±´ÊýÔÚÈËÀà»ùÒò×éÖÐÊÇÒ×±äµÄ £¬ÓÉÓÚÊÖÒÕÊֶεÄÏÞÖÆ £¬ÈËÃǶԲ¸È鶯Îïϸ°ûÔõÑùά³ÖºÍ¿ØÖƺËÌÇÌåDNAµÄ¿½±´ÊýºÍÎȹÌÐÔËùÖªÉõÉÙ¡£¡£±¾Ñо¿Ó¦ÓÃÅÌËãÉúÎïѧºÍÊý×Ö΢µÎʽPCR£¨Droplet digital PCR£©ÒªÁìÆÊÎöÁËÕý³£º£ºÍ°©Ö¢×´Ì¬Ï £¬ÈËÀàºÍСÊó»ùÒò×éÖкËÌÇÌåDNAµÄ¿½±´ÊýºÍÐòÁбäÒìÇéÐΡ£¡£·¢Ã÷ÈËÀà°©Ö¢»ùÒò×éÖкËÌÇÌåDNA¿½±´Êý³öºõÒâÁϵØÏÔÖøïÔÌ­ £¬²¢ÅãͬÐí¶àÆäËû»ùÒò¿½±´ÊýµÄ±äÒì¡£¡£±ðµÄ £¬°©Ö¢»ùÒò×éµÄºËÌÇÌåDNAÐòÁÐÒ²¸üÒ×±¬·¢Í»±ä¡£¡£

ƾ֤ÎÄÏ×Ö¤¾ÝµÄÌáÐÑ £¬Ñо¿ÍŶӽøÒ»²½Ì½ÌÖÁ˰©Ö¢Ä£×ÓÖÐmTOR£¨²¸È鶯ÎïÀ×ÅÁÃ¹ËØ°ÐÂÑ°× £¬mammalian target of rapamycin£©¹¦Ð§ÓëºËÌÇÌåDNA¿½±´ÊýïÔÌ­µÄ¹ØÏµ¡£¡£·¢Ã÷Pten»ùÒò£¨mTORÐźÅͨ·µÄ¸ºµ÷¿ØÒò×Ó£©ÇóýµÄ°×Ѫ²¡Ð¡ÊóÄ£×ÓÖÐ £¬°©Ö¢ÔìѪ¸Éϸ°ûÔçÆÚ¾Í·ºÆðºËÌÇÌåDNA¿½±´ÊýµÄïÔÌ­ £¬µ«Æäϸ°ûÔöÖ³¡¢¡¢¡¢ºËÌÇÌåRNAºÏ³ÉºÍÂѰ׷­ÒëˮһÂɾùÏÔÖøÌá¸ß¡£¡£ËµÃ÷ºËÌÇÌåDNA¿½±´ÊýɥʧÊÇmTORͨ;¾­±í´ïµÄ°©Ö¢µÄÒ»ÖÖ³£¼ûÌØÕ÷¡£¡£ÕâÒ»Ñо¿Ð§¹ûÌáÐÑ £¬²â¶¨ºËÌÇÌåDNA¿½±´Êý £¬¿É³ÉΪԤ²â°©Ö¢¶ÔDNAËðÉËÒ©ÎïÃô¸ÐÐÔµÄÒ»¸ö¼òÆÓ¶øÓÐÓõÄÐÂÖ¸±ê¡£¡£

¡¾ÍøÕ¾µØÍ¼¡¿