11ÔÂ9ÈÕ£¬ngµç×ÓÓÎÏ·ËïÒÝÏɼÍÄîÒ½ÔºÁÖÌìì§½ÌÊÚÍŶӵÄÑо¿ÂÛÎÄ¡°Long noncoding RNA LBCS inhibits self-renewal and chemoresistance of bladder cancer stem cells through epigenetic silencing of SOX2¡±ÔÚÏß½ÒÏþÔÚClinical Cancer Research(IF 2017=10.19£©¡£¡£¡£ÁÖÌìì§½ÌÊںͻƽ¡½ÌÊÚΪͨѶ×÷Õߣ¬³ÂÐñÖúÀíÑо¿Ô±¡¢¡¢Ð»Èñ»Ô²©Ê¿ÉúºÍ¹ËÅô²©Ê¿ÎªµÚÒ»×÷Õß¡£¡£¡£
°òë×°©ÊÇÎÒ¹úÄÐÐÔÃÚÄòÉúֳϵͳ×î³£¼ûµÄ¶ñÐÔÖ×Áö£¬»¯ÁÆÊǰòë×°©×îÖ÷ÒªµÄÖÎÁÆÊÖ¶ÎÖ®Ò»£¬»¯ÁÆÔçÆÚÄÜʹÖ×ÁöËõС£¬µ«ºóÆÚÒò·ºÆð»¯ÁÆÄÍÒ©¶øµ¼ÖÂÖ×ÁöÔٴθ´·¢ºÍÎÞ·¨¿ØÖÆ£¬Òò´Ë»¯ÁÆÄÍÒ©Êǰòë×°©¸´·¢ºÍÖÎÁÆÊ§°ÜµÄÖ÷ÒªÔÒò£¬Ò²ÊÇÁÙ´²µÄÒªº¦ÄÑÌâ¡£¡£¡£ÏÖÔÚº£ÄÚÍâÑо¿Åú×¢Ö×Áö¸Éϸ°ûÊÇÖ×Áö±¬·¢¡¢¡¢¿ªÕ¹¡¢¡¢ÄÍÒ©ºÍ¸´·¢µÄÒªº¦¡£¡£¡£Òò´Ë£¬ÆÊÎö°òë×°©¸Éϸ°ûµ÷¿Ø»¯ÁÆÄÍÒ©µÄ·Ö×Ó»úÖÆ£¬Ñ°ÕÒÌØÒìÐÔ¸ÉÔ¤°ÐµãÊǰòë×°©Ñо¿µÄ½¹µãÎÊÌâ¡£¡£¡£

»úÖÆÊ¾Òâͼ
¸ÃÑо¿Ê×ÏÈͨ¹ý»ùÒòоƬÅжϰòë×°©¸Éϸ°ûÏà¹ØµÄlncRNAs£¬·¢Ã÷lncRNA LBCSÔÚ°òë×°©¸Éϸ°ûºÍ°©×éÖ¯ÖÐÏÔ×ŵͱí´ï£¬ÁÙ´²Ïà¹ØÐÔÆÊÎö·¢Ã÷LBCSÓë·Ö¼¶¡¢¡¢·ÖÆÚ³Ê¸ºÏà¹Ø£¬Óë×ÜÌåÉúÑĺÍÎÞ¼²²¡ÉúÑijÊÕýÏà¹Ø£¬ÊÇÉúÑÄÔ¤ºóµÄ×ÔÁ¦Ô¤²âÒò×Ó¡£¡£¡£ÌåÄÚÍâµÄ¹¦Ð§Ñ§ÊµÑé·¢Ã÷LBCSÄÜÒÖÖÆ°òë×°©¸Éϸ°ûµÄ¸ÉÐÔ¡¢¡¢³ÉÁöºÍ»¯ÁÆÄÍÒ©¡£¡£¡£»£»£»úÖÆÑо¿·¢Ã÷LBCSÄÜÁ¬Ïµ²¢½éµ¼hnRNPKºÍEZH2Ðγɸ´ºÏÎ²¢ÕÙļ¸Ã¸´ºÏÎïµ½SOX2Æô¶¯×ÓÉϵ÷¿ØH3K27me3£¬´Ó¶øÒÖÖÆ¸ÉÐÔ»ùÒòSOX2µÄ±í´ï¡£¡£¡£½øÒ»²½Ñо¿Åú×¢SOX2ÔÚ°òë×°©Öи߱í´ï£¬Óë¸ß·Ö¼¶ºÍÔ¤ºó²»Á¼Ç×½üÏà¹Ø£¬SOX2ÊÇÔö½ø°òë×°©Ï¸°ûµÄ¸ÉÐԺͻ¯ÁÆÄÍÒ©µÄÒªº¦»ùÒò¡£¡£¡£
¸ÃÑо¿Ê״η¢Ã÷lncRNA LBCSÔÚ°òë×°©¸Éϸ°ûµÄ×ÔÎÒ¸üкͻ¯ÁÆÄÍÒ©ÖÐʩչÖ÷ÒªµÄÒÖ°©»ùÒò×÷Óã¬Éϵ÷LBCSÄÜÒÖÖÆ°òë×°©³ÉÁöºÍÔöÌí»¯ÁÆÃô¸ÐÐÔ¡£¡£¡£LBCS-hnRNPK-EZH2-SOX2µ÷¿ØÖáÓÐÍû³ÉΪ¸ÉÔ¤°òë×°©»¯ÁÆÄÍÒ©µÄÐÂÖÎÁưе㡣¡£¡£±¾Ñо¿Îª°ÐÏò°òë×°©¸Éϸ°ûÖÎÁƺÍÌá¸ß°òë×°©»¯ÁÆÃô¸ÐÐÔÌṩ¿ÆÑ§ÒÀ¾ÝºÍÐÂ˼Ð÷¡£¡£¡£
ÉÏÊöÑо¿ÊÂÇé»ñµÃ¹ú¼Ò×ÔÈ»¿ÆÑ§»ù½ðÓÅÒìÇàÄê»ù½ð¡¢¡¢ÃæÉÏÏîÄ¿¡¢¡¢ÇàÄêÏîÄ¿£¬¹ã¶«Ê¡×ÔÈ»¿ÆÑ§»ù½ðºÍ¹ãÖÝÊпƼ¼ÏîÄ¿µÈ»ù½ðµÄ×ÊÖú¡£¡£¡£
ÂÛÎÄÁ´½Ó£º£º£ºhttp://clincancerres.aacrjournals.org/content/early/2018/11/09/1078-0432.CCR-18-1656