ngµç×ÓÓÎÏ·

05

¿ÆÑÐÏ£Íû

ÖÐɽҽѧԺÏîÅô½ÌÊÚÍŶӹØÓÚÈËÀà×Ô±ÕÖ¢Á鳤ÀදÎïÄ£×ÓµÄÑо¿Ð§¹ûÔÚNatureÔÓÖ¾½ÒÏþ

ÔĶÁÁ¿£º£º£º

ngµç×ÓÓÎÏ·ÖÐɽҽѧԺÏîÅô½ÌÊÚ¡¢¡¢¿ÂÇí¸±½ÌÊÚÑо¿ÍŶÓÓëÉîÛÚÏȽøÔºÄÔÈÏÖªÓëÄÔ¼²²¡Ñо¿Ëù¡¢¡¢ÃÀ¹úÂéÊ¡Àí¹¤Ñ§Ôº¡¢¡¢»ªÄÏũҵ´óѧµÈÍŶÓÏàÖú£¬£¬Ó¦ÓÃCRISPR/Cas9 ÊÖÒÕÀÖ³ÉÖÆ±¸³öÐÂÐÍÄ£ÄâÈËÀà×Ô±ÕÖ¢SHANK3»ùÒòÍ»±äµÄÁ鳤ÀදÎïÄ£×Ó£¬£¬²¢»ñµÃ»ùÒòÍ»±ä×ÓÅ®£¬£¬Ê×´ÎÔÚÁ鳤ÀදÎïÖØÏÖÁËÈËÀà×Ô±ÕÖ¢Æ×ϵÕϰ­£¨Phelan-McDermid×ÛºÏÕ÷£©µÄÁÙ´²Ö¢×´£º£º£ºÍ»±äºïÌåÏÖ³ö˯ÃßÕϰ­£¬£¬Ô˶¯È±ÏݺÍÖØ¸´¿Ì°åÐÐΪÔöÌí£¬£¬ÒÔ¼°Éç½»ºÍѧϰÕϰ­¡£¡£¡£¡£¹¦Ð§´Å¹²Õñ³ÉÏñµÄÊý¾ÝÆÊÎöÕ¹ÏÖÁË´óÄÔ¾Ö²¿ºÍÈ«¾ÖÅþÁ¬Ä£Ê½µÄ¸Ä±ä£¬£¬Ö¸Ê¾Éñ¾­»·Â·Òì³£¡£¡£¡£¡£¡£¡£¸ÃÄ£×ӵĽ¨ÉèΪÆÊÎö×Ô±ÕÖ¢·¢²¡»úÀíÒÔ¼°¿ªÕ¹ÁÙ´²¸ÉÔ¤ÒªÁìµÓÚ¨ÁËÖ÷Òª»ù´¡¡£¡£¡£¡£

Ê×Ò³|ngµç×ÓÓÎÏ·Öйú¼¯ÍŹٷ½ÍøÕ¾

SHANK3Í»±äʳзºï¾ßÓÐ×Ô±ÕÖ¢»¼ÕßÀàËÆµÄ´óÄÔÅþÁ¬Ä£Ê½

¸ÃÏîЧ¹ûÓÚ6ÔÂ12ÈÕÔÚ¡¶×ÔÈ»¡·£¨Nature£©ÔÓÖ¾ÒÔ³¤ÎÄÐÎʽÔÚÏß½ÒÏþ£¬£¬ÌâΪ¡°Atypical behaviour and connectivity in SHANK3-mutant macaques¡±¡£¡£¡£¡£ ngµç×ÓÓÎÏ·ÖÐɽҽѧԺÏîÅô½ÌÊÚÓëÖйú¿ÆÑ§ÔºÉîÛÚÏȽøÊÖÒÕÑо¿ÔºÖÜêÍêͽÌÊÚ¡¢¡¢ÃÀ¹úÂéÊ¡Àí¹¤Ñ§Ôº·ë¹úƽ½ÌÊÚ¡¢¡¢»ªÄÏũҵ´óѧÑîÊÀ»ª½ÌÊÚΪÎÄÕµÄÅäºÏͨѶ×÷Õߣ¬£¬ngµç×ÓÓÎÏ·ÖÐɽҽѧԺ¿ÂÇí¸±½ÌÊÚÊÇÅäºÏµÚÒ»×÷Õß¡£¡£¡£¡£

ÏîÅô½ÌÊÚÓë¿ÂÇí¸±½ÌÊÚÍŶÓÒÀÍÐngµç×ÓÓÎÏ·¸Éϸ°ûÓëÔÙÉúҽѧ´óƽ̨£¬£¬Ê¹ÓûùÒò±à¼­ÊÖÒÕ½¨ÉèÁ˶àÖÖÈËÀ༲²¡µÄÁ鳤ÀදÎïÄ£×Ó£¬£¬2016ÄêÔÚ¹ú¼ÊÉÏÊ״ᨵÀÁËʹÓÃTALENs»ùÒò±à¼­ÊÖÒÕ½¨ÉèÄ£ÄâÈËÀàСͷ֢±íÐ͵ÄMCPH1»ùÒòÍ»±äʳзºïÄ£×Ó£¬£¬ÎªÈËÀà´óÄÔ½ø»¯ÓëÏà¹Ø¼²²¡µÄ»úÖÆÑо¿ÌṩÁËÖ÷ÒªÒÀ¾Ý£¨Cell Res, 2016£©¡£¡£¡£¡£

ÂÛÎÄÁ´½Ó£º£º£ºhttps://www.nature.com/articles/s41586-019-1278-0#article-info

¡¾ÍøÕ¾µØÍ¼¡¿