ngµç×ÓÓÎÏ·

05

¿ÆÑÐÏ£Íû

ÉúÃü¿ÆÑ§Ñ§ÔºÕÅÈñ½ÌÊÚÍŶÓÕ¹ÏÖmRNA m5CµÄÐòÁÐ½á¹¹ÌØÕ÷ºÍ¶¯Ì¬×ª±ä¼ÍÂÉ

ÔĶÁÁ¿£º£º

5ÔÂ7ÈÕ£¬ngµç×ÓÓÎÏ·ÉúÃü¿ÆÑ§Ñ§ÔºÕÅÈñ½ÌÊÚÍŶÓÔÚ¡¶×ÔÈ»-½á¹¹ºÍ·Ö×ÓÉúÎïѧ¡·£¨Nature Structural & Molecular Biology£©ÔÓÖ¾½ÒÏþÁËÌâΪ¡°Genome-wide identification of mRNA 5-methylcytosine in mammals¡±µÄÑо¿ÂÛÎÄ¡£¡£¡£¸ÃЧ¹ûÕ¹ÏÖÁËm5CÐÞÊÎÔÚ²¸È鶯Îïϸ°ûϵÓë×éÖ¯µÄmRNAÖеÄ׼ȷ¶¨Î»ºÍ¶¯Ì¬×ª±ä£¬²¢Åú×¢mRNAÉϵÄm5C¾ÝÓÐÆæÒìµÄÐòÁÐºÍ½á¹¹ÌØÕ÷¡£¡£¡£ngµç×ÓÓÎÏ·ÉúÃü¿ÆÑ§Ñ§ÔºÌØÆ¸¸±Ñо¿Ô±»ÆÌΡ¢²©Ê¿Éú³ÂÍñÓ±¡¢²©Ê¿ÉúÁõ½¡ºãΪ¸ÃÂÛÎĵIJ¢ÁеÚÒ»×÷Õߣ¬ÕÅÈñ½ÌÊÚΪͨѶ×÷Õß¡£¡£¡£

5-methylcytosine£¨m5C£©ÐÞÊÎÆÕ±é±£´æÓÚtRNAºÍrRNAÖУ¬È»¶ø¹ØÓÚmRNAÉÏÊÇ·ñ±£´æm5CÐÞÊΣ¬Ñ§½ç±£´æºÜ´óµÄÕùÒé¡£¡£¡£¸ÃÑо¿Í¨Ì«¹ýÎö·¢Ã÷£¬ÏÖÔÚ±¨µ¼µÄ¡°m5C¡±Î»µãÍùÍù³É´Ø±£´æÓÚ¸ßGCº¬Á¿ÇøÓò£¬¶ÔÕë¶ÔNSUN2µÄRNA×ÌÈŲ»Ãô¸Ð£¬Ò²ÎÞ·¨±»m5C¿¹ÌåËù¸»¼¯£¬¼«¿ÉÄÜÊÇʵÑéÒýÈëµÄ¼ÙÑôÐÔ¡£¡£¡£Æ¾Ö¤ÕâÒ»ÌØÕ÷£¬¸ÃÑо¿½¨ÉèÁËÒ»Ì×ÐÂÓ±µÄÉúÎïÐÅϢѧÅÌËãÁ÷³Ì¹ýÂËÔëÒô£¬µÃÒÔ׼ȷµØ¶¨Î»mRNAÉϵÄm5C¡£¡£¡£Í¨¹ý½øÒ»²½ÆÊÎö£¬¸ÃÑо¿·¢Ã÷NSUN2ÒÀÀµµÄm5CλµãÇãÏòÓÚÓµÓÐÒ»¸ö3¡¯¸»GµÄ»ùÐò£¬Í¨³£Î»ÓÚÔÚÒ»¸öС¾±»·½á¹¹µÄµ×²¿£¬ÓëÆätRNAµ×Îï¸ß¶ÈÒ»Ö£¬Õ¹ÏÖÁËmRNA m5C ÐòÁÐºÍ½á¹¹ÌØÕ÷µÄÓÉÀ´¡£¡£¡£¸ÃÑо¿·¢Ã÷³ýÁËNSUN2£¬NSUN¼Ò×åÆäËû³ÉÔ±²»µ÷¿ØmRNA m5Cλµã£¬ÌåÏÖ³ýÁËNSUN¼Ò×å³ÉÔ±£¬¿ÉÄܱ£´æÐµļ׻ù×ªÒÆÃ¸¼ÓÈëÁ˲»ÒÀÀµÓÚNSUN2 µÄmRNA m5CλµãµÄ´ß»¯¡£¡£¡£Í¨¹ý½øÒ»²½¶Ô7¸öÈËÀà×éÖ¯ÓÚ10¸öСÊó×éÖ¯µÄת¼×é²âÐòÆÊÎö£¬»®·ÖÈ·ÈÏÁË3212Óë2498¸ö¸ßÖÃÐŶÈλµã¡£¡£¡£Ð§¹ûÅú×¢£¬ÔÚ²î±ð×éÖ¯ÖÐmRNA m5CλµãµÄÊýÄ¿Óë¼×»ù»¯Ë®Æ½Óкܴó²î±ð¡£¡£¡£ÔÚÈ˺ÍСÊóµÄغÍè¡¢¸ÎÔà¡¢Ðļ¡ºÍ¹Ç÷À¼¡£¬mRNAÉÏÓÐÊý°Ù¸ö¸ßÖÃÐŶȵÄm5Cλµã£¬¶øÔÚÆäËûµÄһЩ×éÖ¯ÔòÁÈÁÈ¿ÉÊý¡£¡£¡£ÁíÍ⣬ÕâЩm5CλµãÔÚÈ˺ÍÀÏÊóÖ®¼ä²¢²»ÊؾÉ£¬ËµÃ÷ËüÃǺܿÉÄÜÊÇÊܵ½Ë³Ê½µ÷¿Ø£¨cis-regulation£©µÄ¡£¡£¡£

ÕâÏîÑо¿¿ª·¢µÄÒªÁìΪmRNA m5CµÄÑо¿ÌṩÁËÐµĹ¤¾ß£»£» £»Æä¹¹½¨µÄ²¸È鶯ÎïmRNA m5C ׼ȷͼÆ×Ϊ·¢Ã÷mRNAÉÏm5CÐÞÊεĵ÷¿ØºÍ¹¦Ð§µÓÚ¨Á˼áʵµÄ»ù´¡¡£¡£¡£°ÂµØÀûÒò˹²¼Â³¿ËÒ½¿Æ´óѧAlexandra Lusser½ÌÊÚÔÚͬÆÚ׫дµÄÆÀÊöÎÄÕ¡°Getting a hold on cytosine methylation in mRNA¡±ÖУ¬ÆÀ¼ÛÕÅÈñ½ÌÊÚ¿ÎÌâ×鿪·¢µÄÐÂÅÌËãÒªÁìÔöÌíÁËm5C¼ì²âµÄ׼ȷ¶È£¬½øÒ»²½ÌṩÁËtRNA¼×»ù»¯×ªÒÆÃ¸NSUN2½éµ¼mRNA¼×»ù»¯µÄÁîÈËÐÅ·þµÄÖ¤¾Ý¡£¡£¡£

ÉÏÊöÑо¿ÊÂÇé»ñµÃ¹ú¼ÒÖØµãÑз¢ÍýÏë¡¢¹ã¶«Ê¡ÖØ´ó¿Æ¼¼×¨Ïî¡¢Öé½­È˲ÅÍýÏëÁ¢Òì´´ÒµÍŶӺ͹ú¼Ò×ÔÈ»¿ÆÑ§»ù½ðίµÈ×ʽð×ÊÖú¡£¡£¡£

ÂÛÎÄÁ´½Ó£º£ºhttps://www.nature.com/articles/s41594-019-0218-x

ÆÀÊöÁ´½Ó£º£ºhttps://www.nature.com/articles/s41594-019-0217-y

¡¾ÍøÕ¾µØÍ¼¡¿