11ÔÂ5ÈÕ£¬£¬ÃÀ¹ú¿ÆѧԺԺ¿¯£¨PNAS£©ÔÚÏß½ÒÏþÁËngµç×ÓÓÎÏ·ÊýѧѧԺÕżҾü¸±½ÌÊÚºÍÖÜÌìÊÙ½ÌÊÚµÄ×îÐÂÑо¿ÂÛÎÄ¡°Markovian Approaches to Modeling Intracellular Reaction Processes with Molecular Memory¡±¡£ÕżҾü¸±½ÌÊÚΪÂÛÎĵĵÚÒ»×÷Õߣ¬£¬ÖÜÌìÊÙ½ÌÊÚΪÂÛÎĵÄͨѶ×÷Õߣ¬£¬ngµç×ÓÓÎϷΪΨһ×÷Õßµ¥Î»¡£
¸ÃÑо¿½â¾öÁËÉú»¯·´Ó³ÏµÍ³£¨°üÀ¨ÉúÎï·Ö×ÓÍøÂ磩Ñо¿ÁìÓòÖеÄÒ»¸öºã¾Ãδ½â¾öµÄÎÊÌ⣬£¬¼´ÔõÑù½¨Ä£º£º£ºÍÆÊÎö´øÓзÖ×ÓÓ°ÏóµÄÉú»¯·´Ó³ÏµÍ³¡£Îª´Ë£¬£¬×÷ÕßÁ¢ÒìÐԵؽ¨ÉèÆðÒ»Ì×ÊÊÓÃÀíÂÛ£¬£¬Æä½¹µãÊǾ²Ì¬¹ãÒ廯ѧÖ÷·½³Ì£¬£¬Ëü°ÑÒ»¸ö·ÇÂíÊÏÎÊÌâת»¯ÎªÒ»¸öÂíÊÏÎÊÌ⣬£¬²¢ÓÉ´ËÕ¹ÏÖ³ö·ÇÂíÊÏÉú»¯·´Ó³ÏµÍ³µÄʵÖÊÌØÕ÷¡£
·ÇÂíÊÏÉú»¯·´Ó³ÏµÍ³¿ÉÓÐÓÃת»¯ÎªÂíÊÏÉú»¯·´Ó³ÏµÍ³¾ÙÐн¨Ä£ÓëÆÊÎö
ºã¾ÃÒÔÀ´£¬£¬Éú»¯·´Ó³ÏµÍ³µÄ½¨Ä£ÓëÆÊÎöÒÀÀµÓÚÂíÊϼÙÉ裬£¬¼´·´Ó³ÎïµÄËæ»úÔ˶¯²»ÊÜÒÔǰ״̬µÄÓ°Ï죬£¬¶ø½öÊÜÄ¿½ñ״̬µÄÓ°Ï졣Ȼ¶ø£¬£¬ÕâÖÖÎÞÓ°ÏóµÄ¼ÙÉèÊǺÜÊÇÀíÏ뻯µÄ£¬£¬ÏÖʵµÄ·´Ó³ÏµÍ³ÊÇ´øÓÐÓ°ÏóµÄ£¬£¬ÀýÕâÑù¶àÉúÎïѧʵÑéÒѾ֤ʵ£º£º£º·Ö×ÓÓ°ÏóÆձ鱣´æÓÚ»ùÒò±í´ïµ÷¿ØϵͳÖУ¬£¬²¢¶Ô»ùÒò±í´ïˮƽÓÐÖ÷ÒªÓ°Ïì¡£ÓÉÓÚ·Ö×ÓÓ°ÏóÄܹ»µ¼Ö·ÇÂíÊÏ·´Ó³Ô˶¯Ñ§£¬£¬ÒÔ¼°ÓÉÓÚ¾µäµÄÂíÊÏÀíÂÛ²»¿É¹»Ö±½ÓÓ¦ÓÃÓÚ·ÇÂíÊÏ·´Ó³Àú³ÌµÄ½¨Ä£ÓëÆÊÎö£¬£¬´Ó¶øµ¼ÖÂÐí¶àÀíÂÛÌôÕ½¡£¾ÓɶԷÇÂíÊÏÉú»¯·´Ó³ÏµÍ³µÄ¶àÄêÑо¿£¬£¬×÷Õß½¨ÉèÆðÒ»Ì×ÊÊÓõÄÀíÂÛÓëÒªÁ죬£¬Ö÷Òª°üÀ¨¾²Ì¬¹ãÒ廯ѧÖ÷·½³Ì£¨stationary generalized chemical master equation£©¡¢¡¢¾²Ì¬¹ãÒ帣¿£¿£¿Ë-ÆÕÀÊ¿Ë·½³Ì£¨stationary generalized Fokker-Planck equation£©ºÍ¾²Ì¬¹ãÒåÏßÐÔÔëÉùÆȽü£¨generalized linear noise approximation£©£¬£¬Õ¹ÏÖ³ö£º£º£ºÖ»¹Ü¸÷¸ö·´Ó³ÎïµÄÔÝ̬¶¯Á¦Ñ§¿ÉÄÜÊÇ·ÇÂíÊϵģ¬£¬µ«Éú»¯·´Ó³ÏµÍ³µÄÕû¸ö΢¹Û±äÁ¿Ëæʱ¼äÑÝ»¯×îºó¶¼Äð³ÉÂíÊϱäÁ¿£¬£¬²»¹Ü·´Ó³ÍøÂçµÄÍØÆËÔõÑùÖØ´óÒÔ¼°²»¹ÜÌØÕ÷»¯·Ö×ÓÓ°ÏóµÄÆÚ´ýʱ¼äÂþÑܵÄÐÎʽÔõÑùÖØ´ó¡£ÕâÈýÖÖÒ»°ãÐÔÃûÌÿª·¢ÁËÑо¿ÖØ´óÉúÎï·Ö×ÓϵͳµÄÐÂÆ«Ïò£¬£¬¾ßÓпíÀ«µÄÓ¦ÓÃÔ¶¾°£¬£¬ÌØÊâÊÇÄܹ»×ÊÖúÈËÃÇ·¢Ã÷еÄÉúÎïѧ֪ʶ¡£
¸ÃÑо¿ÊÂÇé»ñµÃÁ˹ú¼Ò×ÔÈ»¿Æѧ»ù½ð¡¢¡¢¹ãÖÝÊпƼ¼ÍýÏëÏîÄ¿¡¢¡¢¹ã¶«Ê¡ÖصãÁìÓòÑз¢ÍýÏëÏîÄ¿£¬£¬ÒÔ¼°ngµç×ÓÓÎÏ·¹ã¶«Ê¡ÅÌËã¿ÆѧÖصãʵÑéÊҵĴóÁ¦Ö§³Ö¡£
ÂÛÎÄÁ´½Ó£º£º£º http://doi.org/10.1073/pnas.1913926116
µØµã:¹ãÖÝÊÐиÛÎ÷·135ºÅ Óʱà:510275
µç»°: 020-84112828
ngµç×ÓÓÎÏ·°æȨËùÓÐ COPYRIGHT?1999-2022 , SUN YAT-SEN UNIVERSITY