ngµç×ÓÓÎÏ·

05

¿ÆÑÐÏ£Íû

Ö×Áö·ÀÖÎÖÐÐÄÐìÈð»ªÍŶӷ¢Ã÷¿ÉÓÃÓÚ½áÖ±³¦°©É¸²é¡¢¡¢ÔçÆÚÕï¶Ï¼°Ô¤ºóÔ¤²âµÄÑ­»·Ö×ÁöDNA¼×»ù»¯·Ö×Ó±ê¼ÇÎï

ÔĶÁÁ¿£º£º£º

1ÔÂ1ÈÕ£¬£¬£¬ngµç×ÓÓÎÏ·Ö×Áö·ÀÖÎÖÐÐÄÐìÈ𻪽ÌÊÚ¿ÎÌâ×éÔÚ¹ú¼Ê×ÅÃûѧÊõÆÚ¿¯Science Translational Medicine£¨2019ÄêIF=17.161£©½ÒÏþÁËÌâΪ¡°Circulating tumor DNA methylation profiles enable early diagnosis, prognosis prediction, and screening for colorectal cancer¡±µÄÑо¿¡£¡£Ö×Áö·ÀÖÎÖÐÐÄÂæ»Üåû¸±Ö÷ÈÎҽʦ£¬£¬£¬ÕÔÆë¸±Ñо¿Ô±£¬£¬£¬Î¤çâÖ÷ÈÎҽʦµÈΪÎÄÕµĵÚÒ»×÷Õߣ¬£¬£¬ÐìÈ𻪽ÌÊÚÊÇÎÄÕµÄͨѶ×÷Õß¡£¡£ÕâÊÇÐìÈ𻪽ÌÊÚÍŶӽ«Ñ­»·Ö×ÁöDNA£¨ctDNA£©¼×»ù»¯±ê¼ÇÎïÀÖ³ÉÓ¦ÓÃÓڸΰ©µÄÕï¶Ï¼°Ô¤ºóÔ¤²âÖ®ºó£¬£¬£¬ÔÚ°©Ö¢ÒºÌå»î¼ìÁìÓòÈ¡µÃµÄÓÖÒ»ÖØ´óÍ»ÆÆ¡£¡£

ÔÚͨ¹ý¼ì²âѪҺÖÐctDNAÌØ¶¨»ùÒòλµãµÄ¼×»ù»¯Ë®Æ½¶Ô¸Î°©¾ÙÐÐÔçÕï¼°Ô¤ºóÔ¤²âµÄÑо¿Ð§¹û¿¯µÇÔÚ¡¶Nature Materials¡·Ö®ºó£¬£¬£¬ÐìÈ𻪽ÌÊÚÍŶÓÒ»Ö±Æð¾¢Ì½Ë÷ctDNA¼×»ù»¯±ê¼ÇÎïÔÚ½áÖ±³¦°©ÔçÕï·½ÃæÓ¦ÓõĿÉÄÜ¡£¡£¾­ÓɽøÒ»²½Ñо¿£¬£¬£¬ÐìÈ𻪽ÌÊÚÍŶÓÕÒµ½ÁËÓ¦ÓÃctDNA¼×»ù»¯·Ö×Ó±ê¼ÇÎï¶Ô½áÖ±³¦°©¾ÙÐÐɸ²éºÍÔçÆÚÕï¶Ï£¬£¬£¬¼°ÁÆÐ§ºÍÔ¤ºóÔ¤²âµÄÐÂÒªÁì¡£¡£Í¨¹ý³éÈ¡¼¸ºÁÉýµÄѪҺ¼ì²âѪÖÐctDNA¼×»ù»¯µÄ±ê¼ÇÎï¾ÍÄܶԽáÖ±³¦°©¾ÙÐÐÔçÕïɸ²é£¬£¬£¬¸üΪÎÞ´´¡¢¡¢¾­¼Ã¡¢¡¢ÇáÓ¯£¬£¬£¬Í¬Ê±¸üÓÐÀûÓÚÌá¸ß»¼ÕßµÄÒÀ´ÓÐÔ¡£¡£

Ñо¿ÍŶÓÏÈ´ÓTCGAÊý¾Ý¿â»ñÈ¡459Àý¾ßÓÐÍêÕûÁÙ´²¡¢¡¢·Ö×Ó¼°²¡ÀíÐÅÏ¢µÄ½áÖ±³¦°©£¨CRC£©×éÖ¯Êý¾Ý¼¯£¬£¬£¬ÔÙ´Ó¹ýÍùÑо¿Êý¾Ý¿âGSE40279»ñÈ¡754ÀýÕý·²ÈËȫѪ»ùÒò¼×»ù»¯Êý¾Ý£¬£¬£¬É¸Ñ¡³öºòÑ¡ctDNA¼×»ù»¯±ê¼ÇÎïºó£¬£¬£¬¶ÔÓÉngµç×ÓÓÎÏ·Ö×Áö·ÀÖÎÖÐÐĵȶàÖÐÐÄÍøÂçµÄ801ÀýCRC»¼ÕߺÍ1021ÀýÕý³£±ÈÕÕѪ½¬ÌáÈ¡µÄcfDNA¾ÙÐÐÁ˰ÐÏò¼×»ù»¯¼ì²â£¬£¬£¬ÔËÓÃLASSOºÍËæ»úÉ­ÁÖµÈËã·¨£¬£¬£¬É¸Ñ¡³ö9¸öÓÃÓÚÕï¶ÏCRCµÄctDNA¼×»ù»¯±ê¼ÇÎ£¬£¬5¸öÓÃÓÚÔ¤²âCRCÔ¤ºóµÄctDNA¼×»ù»¯±ê¼ÇÎ£¬£¬»ùÓÚÕâЩ¼×»ù»¯±ê¼ÇÎïÀֳɽ¨ÉèÁËCRCÕï¶ÏÄ£×ÓºÍÔ¤ºóÔ¤²âÄ£×Ó¡£¡£Ñо¿ÍŶӻ¹ÔÚ¹ú¼ÊÉÏÊ×´ÎÌá³ö»ùÓÚctDNA¼×»ù»¯Æ×µÄCRC·Ö×Ó·ÖÐÍ£¬£¬£¬ÎªÁÙ´²ÖÎÁÆÌṩÁ˸ü¶àµÄ²Î¿¼ÐÅÏ¢¡£¡£

Ê×Ò³|ngµç×ÓÓÎÏ·Öйú¼¯ÍŹٷ½ÍøÕ¾

ctDNA ¼×»ù»¯Õï¶Ï½áÖ±³¦°©£¬£¬£¬AUC´ï0.96£¬£¬£¬×¼È·ÂʽÏCEAÏÔÖøÌá¸ß29%

ÔÚ¸ÃÑо¿µÄѵÁ·×éºÍÑéÖ¤×éÈËȺÖУ¬£¬£¬CRCÕï¶ÏÄ£×ÓºÍÔ¤ºóÔ¤²âÄ£×Ó¾ùÌåÏÖ³öÁËÁîÈËÖª×ãµÄЧ¹û¡£¡£ÔÚѵÁ·×éºÍÑéÖ¤×éµÄÈËȺÖУ¬£¬£¬¸ÃÕï¶ÏÄ£×Ó׼ȷÂʾùµÖ´ï96%£¬£¬£¬²¢ÇÒÔÚÑéÖ¤×éÖиÃÄ£×ÓÕï¶ÏÃô¸ÐÐÔ´ï87.9%£¬£¬£¬ÌØÒìÐÔ´ï89.6%£¬£¬£¬Ïà¹ØÓÚÏÖÔÚÁÙ´²³£ÓõĽáÖ±³¦°©ÑªÇå±ê¼ÇÎï°©Åß¿¹Ô­CEAµÄ׼ȷÂÊΪ67%£¬£¬£¬Õï¶Ï׼ȷ¶È´ó·ù¶ÈÌá¸ß¡£¡£ÔÚ¶Ô»¼ÕßÔ¤ºóÔ¤²âµÄ׼ȷÐÔ·½Ã棬£¬£¬Æ¾Ö¤ctDNA¼×»ù»¯±ê¼ÇÎïÔ¤ºóÔ¤²âÄ£×ÓÅÌËã»ñµÃÁªºÏÔ¤ºóÆÀ·ÖÖ¸Êý£¨cp-score£©¶Ô»¼ÕßµÄÔ¤ºóÔ¤²âµÄ׼ȷÐÔÒªÏÔןßÓÚÁÙ´²³£ÓõÄÔ¤ºóÖ¸±ê£¬£¬£¬ÈçÖ×ÁöÔ­·¢²¿Î»¡¢¡¢TMN·ÖÆÚ¡¢¡¢CEAµÈ¡£¡£¶ø½«cp-scoreÓëÕâЩͨÀýÔ¤ºóÖ¸±êÁ¬ÏµÒԺ󣬣¬£¬¶Ô»¼ÕßÔ¤ºóÔ¤²âµÄ׼ȷÐÔ»¹Äܹ»»ñµÃ½øÒ»²½µÄÌá¸ß£¬£¬£¬ÔÚѵÁ·×黼ÕßÖжÔÔ¤ºóÔ¤²âµÄ׼ȷÐÔµÖ´ï82%£¬£¬£¬ÔÚÑéÖ¤×黼ÕßÖжÔÔ¤ºóÔ¤²âµÄ׼ȷÐÔµÖ´ï87%¡£¡£¶ÔÔ¤ºóµÄ׼ȷԤ²â£¬£¬£¬¿ÉºÜºÃµÄÖ¸µ¼Ò½Éú¶Ô²î±ðµÄ»¼Õß¾ÙÐиüΪ¸öÌ廯µÄ¾«×¼ÖÎÁÆ£¬£¬£¬ÀýÈç¶ÔÔ¤ºó²»¼ÑÕß×èÖ¹¸øÓèÌ«¹ýµÄÖÎÁÆ£¬£¬£¬¶ø¶Ô¸´·¢¸ßΣ»£»£»¼ÕßÔò¸øÓè¸üΪÆð¾¢µÄ¸¨ÖúÖÎÁƵÈ¡£¡£

Ê×Ò³|ngµç×ÓÓÎÏ·Öйú¼¯ÍŹٷ½ÍøÕ¾

ctDNA¼×»ù»¯Ô¤ºóÔ¤²âÄ£×Ó¿ÉÓÐÓÃÇø·Ö¸ß·çÏպ͵ͷçÏÕÈËȺ

Ñо¿ÍŶӻ¹ÔÚǰհÐÔÐÐÁÐÖÐÑéÖ¤Á˵¥¸öctDNA¼×»ù»¯±ê¼ÇÎïÔÚ½áÖ±³¦°©É¸²éÖеļÛÖµ¡£¡£Í¨¹ý¶Ô1493Àý½áÖ±³¦°©¸ßΣÈËȺͬʱ¾ÙÐеij¦¾µÉ¸²éºÍѪ½¬ctDNA¼×»ù»¯¼ì²âЧ¹û¾ÙÐнÏÁ¿£¬£¬£¬ÏÔʾctDNA¼×»ù»¯±ê¼ÇÎï¿É¼ì²â³ö26ÀýÔçÆÚ³¦°©»¼Õߣ¬£¬£¬26ÀýÏ£ÍûÆÚÏÙÁö£¨°©Ç°²¡±ä£©£¬£¬£¬¶ÔÖ×ÁöµÄ¼ì³öÃô¸ÐÐÔ´ï89.7%£¬£¬£¬ÌØÒìÐÔ´ï86.8%£¬£¬£¬¶ÔÏ£ÍûÆÚÏÙÁöµÄ¼ì³öÂÊÃô¸ÐÐÔ´ï33.3%£¬£¬£¬Ãô¸ÐÐÔºÍÌØÒìÐÔ¾ù½ÏÏÖÓеÄÎÞ´´É¸²éÒªÁìÓÐËùÌá¸ß¡£¡£ÕâÒ»Ñо¿Ð§¹û¹ØÓÚÓÅ»¯½áÖ±³¦°©É¸²é£¬£¬£¬¾ßÓÐÖ÷ÒªµÄÒâÒ壬£¬£¬ÓкÜÊÇÁÉÀ«µÄÓ¦ÓÃÔ¶¾°¡£¡£

ÐìÈ𻪽ÌÊÚÍŶӵÄÕâÏîЧ¹ûÊÇÎÒ¹ú¿ÆÑ§¼ÒÔÚÖ×ÁöÒºÌå»î¼ìÁìÓòÓÖÒ»Ïî¾ßÓйú¼ÊÁìÏÈˮƽµÄÖØ´óÍ»ÆÆ£¬£¬£¬²»µ«ÎªCRCµÄɸ²éÌṩÁËеÄÒªÁ죬£¬£¬Ò²ÎªCRCµÄ¾«×¼ÕïÖÎÌṩÁËÖ÷ÒªµÄ²Î¿¼¡£¡£ÏÖÔÚ¸ÃÍŶÓÈÔÔÚÆð¾¢¿ªÕ¹ctDNA·Ö×Ó±ê¼ÇÎïÔÚÆäËûÖ×Áöɸ²é¡¢¡¢Õï¶Ï¡¢¡¢Ô¤ºóÔ¤²â¡¢¡¢°ÐÏòÒ©ÎïɸѡµÈ·½ÃæµÄ»ù´¡ºÍת»¯Ñо¿£¬£¬£¬Îª·¢Ã÷¸ü¶àµÄÔçÆÚÖ×Áö»¼Õߣ¬£¬£¬½øÒ»²½¸ÄÉÆ»¼ÕßµÄÁÆÐ§ºÍÔ¤ºó£¬£¬£¬Ìṩ¸ü¶à¡¢¡¢¸üÓÐÁ¦µÄ¹¤¾ßºÍÊֶΡ£¡£

ÂÛÎÄÁ´½Ó£º£º£ºhttps://stm.sciencemag.org/content/12/524/eaax7533

¡¾ÍøÕ¾µØÍ¼¡¿