ϸ°ûÄÚ±£´æ×ŶàÖÖ¹¦Ð§Ö÷ÒªµÄË«Á´RNAÁ¬ÏµÂѰף¬£¬£¬ÆäÖÐADARÂѰ׼Ò×åÄÜÁ¬Ïµµ½Ìض¨RNAµÄË«Á´ÇøÓò£¬£¬£¬²¢´ß»¯A¼î»ù±¬·¢ÍѰ±»ù·´Ó³ÌìÉúI¼î»ù£¬£¬£¬µ¼ÖÂA-to-I RNA±à¼¡£¡£ÔÚ²¸È鶯Îïϸ°ûÖУ¬£¬£¬ADARÂѰ׼Ò×庬ÓÐÈý¸ö³ÉÔ±£ºADAR1¡¢¡¢¡¢ADAR2¼°ADAR3£¬£¬£¬ËüÃÇÔÚ¶àÆ÷¹Ù·¢Óý¡¢¡¢¡¢´óÄÔ¹¦Ð§ÖÐʩչÖ÷ÒªµÄ¹¦Ð§¡£¡£×î½üµÄÑо¿Åú×¢ADAR1½éµ¼µÄ·Ç±àÂëÇøÓòRNA±à¼¿ÉÓÃÓÚ±ê¼Ç¡°×ÔÎÒ¡±ºÍ¡°·ÇÎÒ¡±RNA£¬£¬£¬ÔÚÏÈÌìÃâÒßϵͳÖÐÆðÁËÖ÷ÒªµÄ¸ºµ÷¿Ø×÷Óᣡ£ÓÉÓÚRNA±à¼µÄ¸ºµ÷¿ØÐ§Ó¦£¬£¬£¬ÒÖÖÆADAR1µÄ±à¼»îÐÔ¿ÉÒÔ¼«´óµØÔö½øÖ×ÁöÃâÒßÁÆ·¨µÄЧ¹û£¬£¬£¬Òò´ËADAR1¿ÉÒÔ×÷ΪÖ×ÁöÃâÒßÁÆ·¨µÄÖ÷Òª°Ð±ê¡£¡£
±ðµÄ£¬£¬£¬ADARÂѰ׿ÉÒÔÓÃÀ´¾ÙÐж¨µãRNA±à¼¡£¡£Ïà±ÈÓÚDNA±à¼£¬£¬£¬¶¨µãRNA±à¼¾ßÓпɿغͿÉÄæÐÔ£¬£¬£¬²»Ó°Ïì»ùÒò×éÎȹÌÐÔ£¬£¬£¬²¢ÇÒ¿ÉÒÔÖ»µ¼ÈëRNA¶ø·ÇÂѰף¬£¬£¬²»»áÓÕµ¼ÃâÒß·´Ó³£¬£¬£¬ÔÚÁÙ´²ÉϾßÓÐһϵÁÐÓÅÊÆ¡£¡£ÏÖÔÚÒÑÓжà¸öÑо¿Ê¹ÓÃÌØ¶¨µÄÏòµ¼RNAÕÐļADARÂѰ׾ÙÐж¨µãRNA±à¼£¬£¬£¬¿ÉÊÇÕâÒ»ÁìÓò×î´óµÄÎÊÌâÖ®Ò»ÊÇRNA±à¼Ð§Âʵ͡£¡£Õ¹ÏÖÄÚÔ´ADARÔõÑùÓÐÓõÄʶ±ðºÍ±à¼µ×Îï¿ÉÒÔÓÃÓÚÖ¸µ¼ºÍÓÅ»¯RNA°ÐÏò±à¼ÏµÍ³¡£¡£

ADARÂѰ×Á¬ÏµºÍ±à¼RNAË«Á´ÇøÓòʾÒâͼ
¿ËÈÕ£¬£¬£¬ngµç×ÓÓÎÏ·ÉúÃü¿ÆÑ§Ñ§ÔºÕÅÈñ½ÌÊÚÑо¿ÍŶӿª·¢ÁËÒ»¸ö¸ßЧµÄ²¶»ñRNAÁ¬ÏµÂѰ×Ë«Á´RNAµ×ÎïµÄ½¨¿â²âÐòÊÖÒÕ£¨irCLASH£©ÒÔ¼°ºóÐøµÄÒ»ÕûÌ×ÉúÎïÐÅϢѧÆÊÎöÒªÁ죻£»£»Ê×´ÎÔÚת¼×éˮƽÉÏϵͳµØ»æÖÆÁËÈËÀàADARÂѰ׵ÄÄÚÔ´Ë«Á´RNAµ×ÎïͼÆ×£»£»£»Õ¹ÏÖÁ˾öÒéADARÁ¬ÏµÐ§Âʺͱà¼Ð§Âʵĵ×ÎïÌØÕ÷ºÍADARÁ¬Ïµ³¤Ë«Á´RNAµÄÌåÄÚÄ£×Ó¡£¡£
¸ÃÑо¿Ê¹ÓÃirCLASHÊÖÒÕϵͳ¹¹½¨ºÍÆÊÎöÁËÈËÀàADAR1¡¢¡¢¡¢ADAR2¼°ADAR3µÄË«Á´RNAµ×ÎïͼÆ×£¬£¬£¬·¢Ã÷Óë֮ǰƾ֤ÅÌËãÍÆµ¼µÄÑо¿ÉèÏë²î±ð£¬£¬£¬ADAR¾ßÓдó×ڵġ¢¡¢¡¢³¤¾àÀëµÄË«Á´RNAµ×Îï¡£¡£¸ÃÑо¿·¢Ã÷²»ÍêÈ«»¥²¹Åä¶ÔµÄµ×ÎïÓëADARÂѰ×Ò²ÓкܺõÄÇ׺Ͷȣ¬£¬£¬ÌØÊâÊÇADAR2¼Ò×å³ÉÔ±¡£¡£Ñо¿»¹½øÒ»²½Õ¹ÏÖÁ˾öÒéADARÁ¬ÏµÐ§Âʺͱà¼Ð§Âʵĵ×ÎïÌØÕ÷¡£¡£irCLASH²âÐòÊÖÒÕ¼°ºóÐøµÄÕûÌ×ÉúÎïÐÅϢѧÆÊÎöÒªÁìµÄ¿ª·¢ÎªÑо¿Ë«Á´RNAÁ¬ÏµÂѰ׵ÄÄÚÔ´µ×ÎïÌṩÁËÐµĹ¤¾ß¡£¡£Í¬Ê±£¬£¬£¬¸ÃÑо¿Õ¹ÏÖµÄADARÓëµ×ÎïÏ໥×÷Óü°´ß»¯ÌØÕ÷ΪÑо¿Ö°Ô±¿ª·¢¸ßЧµÄRNA±à¼¹¤¾ßÌṩÁË×ÊÔ´±¦¿â¼°Ë¢ÐÂÆ«Ïò¡£¡£
¸ÃÏîÊÂÇé (irCLASH reveals RNA substrates recognized by human ADARs) ÓÚ3ÔÂ23ÈÕ½ÒÏþÔÚ¡¶×ÔÈ»-½á¹¹ºÍ·Ö×ÓÉúÎïѧ¡·£¨Nature Structural & Molecular Biology£©ÔÓÖ¾£¬£¬£¬ngµç×ÓÓÎÏ·ÉúÃü¿ÆÑ§Ñ§ÔºÌØÆ¸¸±Ñо¿Ô±ËÎÓñÁú²©Ê¿¼°²©Ê¿ÉúÑîÎıøÎª¸ÃÂÛÎĵIJ¢ÁеÚÒ»×÷Õߣ¬£¬£¬ÕÅÈñ½ÌÊÚΪͨѶ×÷Õß¡£¡£ÉÏÊöÑо¿ÊÂÇé»ñµÃ¹ú¼ÒÖØµãÑз¢ÍýÏë¡¢¡¢¡¢¹ã¶«Ê¡ÖØ´ó¿Æ¼¼×¨Ïî¡¢¡¢¡¢Öé½È˲ÅÍýÏëÁ¢Òì´´ÒµÍŶӺ͹ú¼Ò×ÔÈ»¿ÆÑ§»ù½ðίµÈ×ʽð×ÊÖú¡£¡£
ÂÛÎÄÁ´½Ó£ºhttps://www.nature.com/articles/s41594-020-0398-4