ngµç×ÓÓÎÏ·ÐÂÎÅÍøѶ£¨Í¨Ñ¶Ô±»ÆÑ޾꣩Ö×ÁöתÒÆÊÇÆäÖÂËÀµÄÖ÷ÒªÒòËØ£¬£¬£¬ÆäÖйÇתÒÆÓÈÉõ¡£¡£¡£ÈéÏÙ°©µÄ¹ÇתÒÆ·¢²¡Âʸߴï65~80%£¬£¬£¬¼Ì¶øÒýÆðÍç¹ÌÐÔ¹ÇÍ´¡¢¼¹Éñ¾Õ¥È¡¡¢¸ß¸ÆѪ֢¡¢¹ÇÕÛ¼°¹ÇÈÜÊ´µÈÖÂÃüÐÔ²¢·¢Ö¢£¬£¬£¬ÑÏÖؽµµÍ»¼ÕßµÄÉúÑÄÖÊÁ¿¡£¡£¡£Òò´Ë£¬£¬£¬ÓÐÓ÷ÀÖÎÈéÏÙ°©¼°ÆäÔ¶¶Ë¹ÇתÒÆÊÇÁÙ´²Ö®¼±Ðè¡£¡£¡£
ngµç×ÓÓÎϷҩѧԺÕÔ´ºË³½ÌÊÚ¿ÎÌâ×éºã¾ÃרעÓÚÈéÏÙ°©¹ÇתÒÆÖÎÁÆÑо¿£¬£¬£¬¿ËÈÕÔÚȨÍþÆÚ¿¯Nature communicationsÔÓÖ¾ÔÚÏß½ÒÏþÁËÌâΪ¡°Engineered macrophages as near-infrared light activated drug vectors for chemo-photodynamic therapy of primary and bone metastatic breast cancer¡±µÄÑо¿ÂÛÎÄ£¬£¬£¬²¢ÒÑÉêÇë1ÏîÖйú·¢Ã÷רÀû£¨ÉêÇëºÅ£ºCN202110760793.7£©¡£¡£¡£¸ÃÑо¿»ùÓÚÈéÏÙ°©¹ÇתÒƵļ²²¡ÌØÕ÷£¬£¬£¬ÕûºÏ°ÂɳÀû²¬Ç°Ò©¼°¹âÃô»îÐÔ·Ö×ÓµÄÓÅÊÆ£¬£¬£¬¹¹½¨Á˽üºìÍâ¹â¼¤»îÐ͹¤³Ì»¯¾ÞÊÉϸ°û-Ç°Ò©µÝÒ©ÔØÌ壬£¬£¬Ö¼ÔÚʵÏÖ¹â¿ØÊÍÒ©¼°»¯ÁÆ-¹â¶¯Á¦£¨PDT£©ÁªºÏÖÎÁƵÄЧ¹û¡£¡£¡£
¸Ãϸ°ûµÝҩϵͳ¾ßÓÐÔØÒ©Á¿¸ß¡¢Ï¸°û»îÁ¦¸ß¡¢µÝҩЧÂʸ߼°Ò©Îï¿É¿ØÊͷŵÈÌØÕ÷£¬£¬£¬ÓÚÌåÄÚ¿Éͬ²½°ÐÏòµ½Ô·¢Áö¼°¹ÇתÒÆÁöÇøÓò£¨ÈçͼËùʾ£©¡£¡£¡£ÔÚÔ·¢Ö×Áö²¿Î»¾ÙÐнüºìÍâ¹âÕÕÉ䣬£¬£¬¿É¼¤»î¹âÃô»îÐÔ·Ö×ӵĹ⶯Á¦ÖÎÁÆ£¬£¬£¬ÊµÏÖ£º¢Ù¿É¿Ø´¥·¢²¢¼ÓËÙ°ÂɳÀû²¬´Óϸ°ûÔØÌåÖеÄÊÍ·Å£¬£¬£¬Ê©Õ¹ÆäÓÕµ¼Ï¸°ûÃâÒßÔÐÔéæÃü£¨immunogenic cell death, ICD£©¹¦Ð§£»¢Ú»¯ÁÆÓë¹â¶¯Á¦ÖÎÁƵÄÁªºÏ£¬£¬£¬²»µ«ÏÔÖøÒÖÖÆÔ·¢Ö×Áö£¬£¬£¬ÇÒÄÜÁªºÏÓÕµ¼ICDµÄ±¬·¢¼¤»îÃâÒßϵͳ£¬£¬£¬Ôö½øÊ÷ͻ״ϸ°û£¨dentritic cells, DCs£©³ÉÊ죬£¬£¬²¢Ôö½øÁöÄÚCD8+Tϸ°ûºÍCD4+Tϸ°ûµÄ½þÈ󣬣¬£¬Í¬Ê±Ìá¸ßѪÇåÖÐIFN-¦ÃºÍTNF-¦ÁµÄˮƽ£¬£¬£¬ÓëPD-L1¿¹ÌåÁªºÏºóÏÔÖøÒÖÖÆÔ·¢Áö¼°¹ÇתÒÆÁö£¬£¬£¬²¢ÏÔÖø»º½âÖ×ÁöתÒƵ¼ÖµĹÇÈÜÊ´¡£¡£¡£±ðµÄ£¬£¬£¬¸Ã»¯ÁÆ-¹â¶¯Á¦-ÃâÒßÁªºÏÖÎÁÆϵͳ¸³ÓèÁËСÊóºã¾Ã¿¹Ö×ÁöÃâÒßÓ°ÏóЧӦ£¬£¬£¬²¢ÏÔÖøÑÓÉìÁËСÊóµÄÉúÑÄÆÚ£¬£¬£¬ÇÒÉúÎïÏàÈÝÐÔÓÅÒì¡£¡£¡£
¸Ã¹¤³Ì»¯¾ÞÊÉϸ°ûµÝÒ©ÔØÌåµÄÖÎÁÆģʽ£¬£¬£¬ÎªÈéÏÙ°©Ô·¢¼°¹ÇתÒƵÄÖÎÁÆÌṩÁËÒ»ÖÖ»¯ÁÆ-¹â¶¯Á¦-ÃâÒßÐͬÖÎÁƵÄÐÂģʽ¡£¡£¡£
¹¤³Ì»¯¾ÞÊÉϸ°ûµÝÒ©ÔØÌåµÄ×÷ÓûúÖÆʾÒâͼ
ngµç×ÓÓÎϷҩѧԺÕÔ´ºË³½ÌÊÚΪÂÛÎĵÄͨѶ×÷Õߣ¬£¬£¬Ò©Ñ§Ôº»ÆÑ޾격ʿºóΪÂÛÎĵÚÒ»×÷Õß¡£¡£¡£¸ÃÑо¿»ñµÃ¹ú¼Ò×ÔÈ»¿Æѧ»ù½ðÓëÖйú²©Ê¿ºó¿Æѧ»ù½ðµÄ¾·ÑÖ§³Ö¡£¡£¡£
ÂÛÎÄÁ´½Ó£ºhttps://doi.org/10.1038/s41467-021-24564-0
µØµã:¹ãÖÝÊÐиÛÎ÷·135ºÅ Óʱà:510275
µç»°: 020-84112828
ngµç×ÓÓÎÏ·°æȨËùÓÐ COPYRIGHT?1999-2022 , SUN YAT-SEN UNIVERSITY