ngµç×ÓÓÎÏ·

03
Ê×Ò³ / ½Ìѧ¿ÆÑÐ / ÕýÎÄ

¿µÌú°î¡¢ÎäÔ¶ÖÚÍŶӷ¢Ã÷ASB7À©ÔöÐÍÖ×Áö»¼Õß¿ÉÄÜÊÇPARPÒÖÖÆ¼ÁµÄDZÔÚ»ñÒæÈËȺ

¸å¼þȪԴ£º£º£ºÖ×Áö·ÀÖÎÖÐÐÄ ±à¼­£º£º£ºÎâÁ¢¼á ÉóºË£º£º£ºËïÒ«±ó ÔĶÁÁ¿£º£º£º

ngµç×ÓÓÎÏ·ÐÂÎÅÍøÑ¶£¨Í¨Ñ¶Ô±ÎÄÏòÑô¡¢³Âä]¡¢Ö£Ãôɺ£©2025Äê5ÔÂ30ÈÕ£¬£¬Ö×Áö·ÀÖÎÖÐÐÄ¿µÌú°î¡¢ÎäÔ¶ÖÚÍŶÓÔÚ¹ú¼ÊÆÚ¿¯¡¶¿ÆÑ§¡·½ÒÏþÁËÌâΪ¡°ASB7ÊÇH3K9me3±í¹ÛÒÅ´«µÄ¸ºÏòµ÷¿Ø·Ö×Ó¡±µÄÑо¿ÂÛÎÄ¡£Ñо¿Õ¹ÏÖÁËASB7À©Ôöµ¼Ö»ùÒò×é²»Îȹ̲¢¸³ÓèÖ×Áö¶ÔPARPiÃô¸ÐÐÔ£¬£¬Î´À´»ò¿ÉÄÜΪASB7À©ÔöÐÍÖ×Áö»¼ÕßÌṩеÄÖÎÁÆÆ«Ïò¡£

Ñо¿ÍŶÓͨ¹ýÈ«»ùÒò×鹿ģµÄCRISPR-Cas9ÒÅ´«Ñ§É¸Ñ¡£¬£¬·¢Ã÷E3·ºËØÅþÁ¬Ã¸ASB7ÊÇH3K9me3µÄ½¹µã¸ºµ÷¿ØÒò×Ó¡£ÔÚµ÷¿Ø»úÖÆÉÏ£¬£¬H3K9me3µÄÔĶÁÆ÷HP1¿ÉÕÐļASB7ÖÁÒìȾɫÖÊÇøÓò½µ½âSUV39H1£¬£¬ÕâÒ»Àú³ÌÊܵ½Ï¸°ûÖÜÆÚ¼¤Ã¸CDK1-Cyclin B1ÑÏÃÜ¿ØÖÆ£¬£¬½øÈëÓÐË¿ÆÆËéMÆÚºó£¬£¬CDK1Á×ËữASB7²¢×è¶ÏÆä¶ÔSUV39H1µÄ·ºËØ»¯½µ½â£¬£¬°ü¹ÜÁËH3K9me3ÔÚËæºóϸ°ûÖÜÆÚÖеÄÖØÐÞ¡£¸ÃÑо¿Åú×¢£¬£¬ÔÚ²¸È鶯ÎïÌåϸ°û£¨º¬Ö×Áöϸ°û£©ÖУ¬£¬¡°¶Á-д-½µ½â¡±Æ½ºâ£¬£¬¶ø·Ç¾­µäµÄ¡°¶Á-д-²Á³ý¡±Æ½ºâ£¬£¬¿ÉÄÜÊÇH3K9me3ά³Ö±í¹ÛÒÅ´«ÎÈ̬µÄ»ù±¾»úÖÆ¡£

5D5C5439C589AFAAD1069027DA8_2630D1C9_53D61

ͼ1. HP1-SUV39H1-ASB7½éµ¼µÄ¡°¶Á-д-½µ½â¡±Æ½ºâ¿ØÖÆH3K9me3±í¹ÛÒÅ´«

DNAË«Á´¶ÏÁÑËðÉËλµã»á±¬·¢H3K9me3ÐÞÊΣ¬£¬½ø¶ø¼¤»îÏÂÓμ¶ÁªËðÉËÐÞ¸´Í¨Â·¡£ASB7ÔÚ¶àÖÖÖ×ÁöÖгÊÏÖÀ©Ôö״̬£¬£¬Õâµ¼ÖÂË«Á´¶ÏÁÑλµãµÄH3K9me3ÐÞÊÎˮƽȱ·¦£¬£¬½ø¶øÒýÆðÍ¬Ô´ÖØ×éÐÞ¸´ÊÜËð¡£Ï¸°û¼°¶¯ÎïʵÑéÅú×¢£¬£¬ASB7¸ß±í´ïÔöÇ¿ÁËÖ×Áöϸ°û¶ÔPARPÒÖÖÆ¼ÁµÄÃô¸ÐÐÔ¡£Ð§¹ûÌáÐÑ£¬£¬ASB7À©ÔöÐÍÖ×Áö»¼Õß¿ÉÄÜÊÇPARPÒÖÖÆ¼ÁµÄDZÔÚ»ñÒæÈËȺ¡£

Ô­ÎÄÁ´½Ó£º£º£ºhttps://www.science.org/doi/10.1126/science.adq7408?sessionid=511868241


¡¾ÍøÕ¾µØÍ¼¡¿