ngµç×ÓÓÎÏ·ÐÂÎÅÍøÑ¶£¨Í¨Ñ¶Ô±ÕÂÖÇçù£©¿ËÈÕ£¬ÖÐɽһԺÊàŦÍâ¿ÆÊ¢è±Òå½ÌÊÚ¡¢ÕÅ×Ï»úÖ÷ÈÎҽʦÓ뾫׼ҽѧÑо¿ÔºÅíËë½ÌÊÚÍŶÓÏàÖú£¬ÔÚ·çʪ²¡ÁìÓò¶¥¼¶ÆÚ¿¯Annals of the Rheumatic Diseases£¨Ó°ÏìÒò×Ó£º£º20.3£©ÉϽÒÏþÑо¿ÎÄÕ¡£¡£
¸ÃÑо¿Í¨¹ýµ¥Ï¸°ûת¼×é²âÐòÒÔ¼°¿Õ¼äת¼×é²âÐòÖÜÈ«ÆÊÎöÀà·çʪÐÔÊàŦÑ×£¨RA£©»¼ÕߵĻ¬Ä¤Î¢ÇéÐΣ¬Ê×´ÎÕ¹ÏÖITGA5+»¬Ä¤³ÉÏËάϸ°ûÊǼÓÈëRA»î¶¯ÆÚÏ£ÍûµÄÒªº¦Ï¸°û£¬ÓÕµ¼ÁËCXCL13hiPD-1hiÍâÖܸ¨ÖúTϸ°û (TPHs)µÄ·Ö»¯£¬ÎªRAµÄÖÎÁÆÌṩÁËаеãºÍÐÂ˼Ð÷¡£¡£
RAÊÇÒ»ÖÖÒÔ»¬Ä¤Ñ×֢Ϊ²¡Àí»ù´¡µÄ×ÔÉíÃâÒßÐÔ¼²²¡£¡£¬×îÖÕ¿ÉÄܵ¼ÖÂÊàŦ»ûÐΡ£¡£RA»¼ÕߵϬĤÑ×Ö¢ÌåÏÖ³ö¶àÑùÐÔ£¬Ö÷ÒªÌåÏÖÔÚÃâÒßϸ°ûµÄ½þÈóºÍ»ùÖÊϸ°ûµÄ»î»¯¡£¡£È»¶ø£¬ÏÖÔÚÉв»ÇåÎú¼ÓÈë¸Ã¼²²¡µÄÒªº¦Ï¸°ûÑÇȺ¡£¡£
±ðµÄ£¬»¬Ä¤ÖеĻùÖÊϸ°ûÓëÃâÒßϸ°ûÅäºÏ¼ÓÈëRAµÄ»¬Ä¤Ñ×Ö¢·´Ó³¡£¡£RA»¬Ä¤Öб£´æÒ»¸ö¸ß¶ÈÖØ´óµÄÃâÒßµ÷¿ØÍøÂ磬ÉîÈëÑо¿»¬Ä¤Î¢ÇéÐÎÖÐÃâÒßϸ°ûºÍ»ùÖÊϸ°ûµÄ×é³É¡¢·Ö×ÓÌØÕ÷¡¢¿Õ¼äÂþÑܼ°ÆäÏ໥×÷Ó㬹ØÓÚÕ¹ÏÖRAµÄ·¢²¡»úÖÆ¾ßÓÐÖ÷ÒªÒâÒå¡£¡£
¸ÃÑо¿¶ÔRA»¼Õߺ͹ÇÊàŦÑ×£¨OA£©»¼ÕߵϬĤ×éÖ¯¾ÙÐÐÁ˵¥Ï¸°ûת¼×é¡¢Tϸ°ûÊÜÌå¼°¿Õ¼äת¼×é²âÐò£¬Ê¶±ð³ö°üÀ¨ÃâÒßϸ°ûºÍ¹ÌÓÐϸ°ûÔÚÄÚµÄ45¸öϸ°ûÑÇȺ£¬Ïêϸ»æÖÆÁËRA»¼Õß»¬Ä¤µÄµ¥Ï¸°ûºÍ¿Õ¼äת¼×éͼÆ×¡£¡£
Ñо¿·¢Ã÷£¬ITGA5+»¬Ä¤³ÉÏËάϸ°ûÊÇRA»¼Õß»¬Ä¤ÖмÓÈë¼²²¡Àú³ÌµÄÒªº¦Ï¸°û£¬ÕâÀàϸ°ûÔÚ»ùÖÊÖØËÜÖÐʩչ×÷Óã¬ÇҸ߱í´ïPOSTN¡¢COL3A1¡¢CCL5ºÍTGFB1µÈ»ùÒò£¬¸»¼¯ÓÚÃâÒßµ÷¿ØÏà¹ØÍ¨Â·¡£¡£
ITGA5+»¬Ä¤³ÉÏËάϸ°ûÔÚRA»î¶¯ÆÚ»¼Õß¼°ÁܰÍϸ°û½þÈóÐÍ»¬Ä¤Ñ×ÖÐÉϵ÷£¬¿ÉÄÜÓëRAµÄÖÎÁÆ·´¿¹ÐÔÏà¹Ø¡£¡£Õâһϸ°ûÑÇȺ¿ÉÄÜÔ´×ÔDPP4+PI16+CD34+³ÉÏËάϸ°ûµÄ·Ö»¯¡£¡£ITGA5+»¬Ä¤³ÉÏËάϸ°û¿ÉÄÜÔÚ»¬Ä¤Ñ×Ö¢µÄÔçÆÚ½×¶Î·ºÆð£¬²¢Í¨¹ýÉøÍ¸TGF-¦Â1ÓÕµ¼ÖÉ×ÓCD4+ Tϸ°ûÏòCXCL13hi PD-1hi TPHsÆ«Ïò·Ö»¯¡£¡£ÊàŦǻÄÚ×¢ÉäITGA5+»¬Ä¤³ÉÏËάϸ°û»á¼ÓÖØ½ºÔÓÕµ¼ÊàŦÑ×СÊóµÄ»¬Ä¤Ñ×Ö¢ºÍ¹ÇÆÆË𡣡£

×ÛÉÏ£¬¸ÃÑо¿ÉîÈëÆÊÎöÁËRA»¼Õß»¬Ä¤Î¢ÇéÐÎÖÐÃâÒßϸ°ûºÍ¹ÌÓÐϸ°ûµÄ×é³É£¬Ê×´ÎÅжÏÁËITGA5+»¬Ä¤³ÉÏËάϸ°ûÑÇȺ£¬Õ¹ÏÖÆäÔÚRAµÄÁÙ´²ÒâÒ壬Ìá³öCD45- CD31- PDPN+ ITGA5+ »¬Ä¤³ÉÏËάϸ°ûÓëCXCL13hiPD-1hi TPHs»¥×÷ÔÚRAµÄлúÖÆ£¬ÎªRAµÄ¾«×¼ÖÎÁÆÌṩÁËÐÂÕ½ÂÔºÍDZÔڰе㡣¡£
¸ÃÂÛÎÄÊÇÖÐɽһԺÁÙ´²¿ÆÊÒÓ뾫׼ҽѧÑо¿ÔºÏàÖúµÄÓÖÒ»¸ßˮƽЧ¹û¡£¡£ngµç×ÓÓÎÏ·Á¥ÊôµÚÒ»Ò½ÔºÊàŦÍâ¿ÆÖúÀíÑо¿Ô±Ö£ÁØÁ¦ÎªµÚÒ»×÷Õߣ¬Ê¢è±Òå½ÌÊÚ¡¢ÕÅ×Ï»úÖ÷ÈÎҽʦºÍ¾«×¼Ò½Ñ§Ñо¿ÔºÅíËë½ÌÊÚΪÂÛÎÄÅäºÏͨѶ×÷Õß¡£¡£
ÂÛÎÄÁ´½Ó£º£º
https://ard.bmj.com/content/early/2024/10/31/ard-2024-225778