ngµç×ÓÓÎÏ·

03
Ê×Ò³ / ½Ìѧ¿ÆÑÐ / ÕýÎÄ

ÎⳬÍŶÓÕ¹ÏÖÓÄÃÅÂݸ˾úѬȾ¼ÓÖØÀà·çʪÊàŦÑ×Ï£ÍûµÄлúÖÆ

¸å¼þȪԴ£º£ºÁ¥ÊôµÚ°ËÒ½Ôº ±à¼­£º£ºÌ¸Ï£¡£¡¢ÎâÁ¢¼á ÉóºË£º£ºËïÒ«±ó ÔĶÁÁ¿£º£º

ngµç×ÓÓÎÏ·ÐÂÎÅÍøÑ¶£¨Í¨Ñ¶Ô±ËÎÀ¼¹ð£©¿ËÈÕ£¬Á¥ÊôµÚ°ËÒ½ÔºÎⳬ½ÌÊÚÍŶÓÔÚ¹ú¼Ê×ÅÃûÆÚ¿¯Annals of the Rheumatic Diseases£¨ÖпÆÔº1Çø£¬TopÆÚ¿¯£¬IF=20.3£©½ÒÏþÁËÌâΪ¡°Helicobacter pylori upregulates PAD4 expression via stabilising HIF-1¦Á to exacerbate rheumatoid arthritis¡±µÄÑо¿ÂÛÎÄ¡£¸ÃÑо¿Õ¹ÏÖÁËÓÄÃÅÂݸ˾ú£¨H. pylori£©Ñ¬È¾¶ÔÀà·çʪÐÔÊàŦÑ×£¨RA£©Ï£ÍûµÄÓ°Ï죬ΪRAµÄÖÎÁÆÌṩÁËDZÔÚµÄаеãºÍÖÎÁÆË¼Ð÷¡£

RAÊÇÒ»ÖÖ³£¼ûµÄÂýÐÔÑ×Ö¢ÐÔ¼²²¡£¬²¡ÒòÖØ´ó£¬ÓëÒÅ´«¡¢ÇéÐεȶàÖÖÒòËØÇ×½üÏà¹Ø¡£½üÄêÀ´Ñо¿·¢Ã÷H. pyloriѬȾ²»µ«Óë賦¼²²¡ÓйØ£¬»¹¿ÉÄܼÓÈë¶àÖÖ賦Íâ¼²²¡µÄ¿ªÕ¹¡£

È»¶ø£¬H. pyloriѬȾÔõÑùÓ°ÏìRAÏ£ÍûÉÐÎÞ±¨µÀ¡£±¾Ñо¿ÒÔRA»¼ÕßΪÑо¿¹¤¾ß£¬ÉîÈë̽ÌÖÁËH. pyloriѬȾÔÚRAÀú³ÌÖеÄ×÷ÓûúÖÆ¡£Ñо¿·¢Ã÷£¬H. pyloriѬȾͨ¹ýÎȹÌȱÑõÓÕµ¼Òò×Ó1¦Á£¨HIF-1¦Á£©µÄ±í´ï£¬Éϵ÷ëÄ»ù¾«°±ËáÍÑÑǰ·Ã¸4£¨PAD4£©µÄˮƽ¡£

PAD4ÊÇRA²¡³ÌÖÐÒªº¦Ã¸£¬Æäͨ¹ýÔö½øÂѰ×Öʹϰ±Ëữ£¬¼¤»îÃâÒßϵͳ£¬ÒýÆð×ÔÉíÃâÒß·´Ó³£¬½ø¶ø¼ÓÖØRA²¡Çé¡£±¾Ñо¿Ê×´ÎÕ¹ÏÖÁËH. pyloriѬȾͨ¹ýHIF-1¦Á/PAD4Õâһ;¾¶¼ÓÈëRA²¡³ÌµÄ·Ö×Ó»úÖÆ¡£

E7B757E87604E74238A6B8F29F9_72A5BE57_75B0A

¸ÃÑо¿ÎªH. pyloriѬȾ¼ÓÈëRAÏ£ÍûÌṩÁËеÄÖ¤¾Ý£¬ÕâÒ»Ñо¿Ð§¹ûΪÁÙ´²ÖÎÁÆÌṩÁËеÄ˼Ð÷£¬Î´À´ÓÐÍûͨ¹ýÕë¶ÔH. pyloriµÄÖÎÁÆÀ´¼õÇáRA»¼ÕߵIJ¡Ç飬´Ó¶ø¸ÄÉÆ»¼ÕßµÄÉúÑÄÖÊÁ¿¡£

Á¥ÊôµÚ°ËÒ½Ôº²©Ê¿Ñо¿ÉúÎâ»ÜΪÂÛÎĵĵÚÒ»×÷Õߣ¬Îⳬ½ÌÊÚΪÅäºÏͨѶ×÷Õߣ¬ngµç×ÓÓÎÏ·Á¥ÊôµÚ°ËҽԺΪÂÛÎĵÚÒ»Íê³Éµ¥Î»ºÍ×îºóͨѶ×÷Õßµ¥Î»¡£

±¾Ñо¿»ñµÃÁ˹ú¼Ò×ÔÈ»¿ÆÑ§»ù½ðºÍ¹ã¶«Ê¡×ÔÈ»¿ÆÑ§»ù½ðµÄ×ÊÖú¡£

ÂÛÎÄÁ´½Ó£º£ºhttps://ard.bmj.com/content/early/2024/08/06/ard-2023-225306.long


¡¾ÍøÕ¾µØÍ¼¡¿