ngµç×ÓÓÎÏ·

03
Ê×Ò³ / ½Ìѧ¿ÆÑÐ / ÕýÎÄ

ngµç×ÓÓÎÏ·ÖÐɽҽѧԺ/Á¥ÊôµÚÈýÒ½Ôº¡¢¡¢¸ßÖÝÊÐÈËÃñÒ½ÔºÁªºÏÍŶӷ¢Ã÷ÐÄÍâĤ֬·¾-½»¸ÐÏ໥×÷ÓÃÓÕ·¢ÐÄÂÉʧ³£µÄлúÖÆ

¸å¼þȪԴ£º£º£ºÖÐɽҽѧԺ ±à¼­£º£º£ºÌ¸Ï £¡£¡¢¡¢Â¬ì½Î¬ ÉóºË£º£º£ºËïÒ«±ó ÔĶÁÁ¿£º£º£º

ngµç×ÓÓÎÏ·ÐÂÎÅÍøѶ£¨Í¨Ñ¶Ô±ÕÅÓñçù£©ÐÄÂÉʧ³££¨Arrhythmia£©Ó°Ïì×ÅÈ«ÇòÁè¼Ý1200ÍòÈË£¬ÇÒ·¢²¡ÂÊÒ²ÔÚÒ»Ö±ÉÏÉý£¬ÊÇÐÄÔ´ÐÔâ§ËÀµÄÖ÷ÒªÔ­ÒòÖ®Ò»¡£¡ £¡£¡£ÐÄÂÉʧ³£ÓÕ·¢ÒòËØÖڶ࣬Ñо¿Åú×¢½»¸ÐÉñ¾­ÏµÍ³£¨Sympathetic nervous system, SNS£©»î¶¯Òì³£º£º£ºÍÐÄÍâĤ֬·¾(Epicardial adipose tissue, EAT)ÔöºñÊÇÐÄÂÉʧ³£±¬·¢µÄÖ÷ÒªµÄ×ÔÁ¦·çÏÕÒòËØ¡£¡ £¡£¡£ÐÄÍâĤ֬·¾°üÈÆ×Ŵ󲿷ÖÐÄÔཻ¸ÐÉñ¾­£¬Á½ÕßÌØÊâµÄλÖùØϵÌáÐÑÐÄÍâĤ֬·¾ºÍÐĽ»¸ÐÉñ¾­Ö®¼äµÄÏ໥×÷ÓÿÉÄÜÔÚÐÄÂÉʧ³£±¬·¢ÖÐÊÎÑÝÖ÷ÒªµÄ½ÇÉ«¡£¡ £¡£¡£È»¶ø£¬ÓÉÓÚÎïÖÖ²î±ðºÍÂ×ÀíÏÞÖÆ£¬ÏÖÔÚÉÐÎÞÖ±½ÓÖ¤¾Ý֤ʵ֬·¾-½»¸ÐÉñ¾­Ï໥×÷ÓüÓÈëÐÄÂÉʧ³£µÄ±¬·¢¡£¡ £¡£¡£

¿ËÈÕ£¬ngµç×ÓÓÎÏ·ÖÐɽҽѧԺÀîΰǿ½ÌÊÚ¡¢¡¢ÏîÅô½ÌÊÚÍŶÓ¡¢¡¢ngµç×ÓÓÎÏ·Á¥ÊôµÚÈýÒ½ÔºÖì½àÃ÷½ÌÊÚÍŶӺ͸ßÖÝÊÐÈËÃñÒ½ÔºÖìÐãÁú½ÌÊÚÍŶÓÏàÖúÔÚCell Reports MedicineÔÓÖ¾ÉϽÒÏþÌâΪ¡°The adipose-neural axis is involved in epicardial adipose tissue-related cardiac arrhythmias¡±µÄÎÄÕ£¬ÀÖ³ÉÕ¹ÏÖÁËÐÄÍâĤ֬·¾-ÐĽ»¸ÐÉñ¾­ÔÚÐÄÂÉʧ³£ÖеÄÖ÷Òª×÷Óò¢ÆÊÎöÁËÆä×÷ÓûúÖÆ¡£¡ £¡£¡£

¸ÃÑо¿Ê¹ÓøÉϸ°ûȪԴµÄÐļ¡Ï¸°û¡¢¡¢½»¸ÐÉñ¾­ÔªºÍÖ¬·¾Ï¸°û½¨ÉèÁ˽»¸Ð-Ðļ¡¡¢¡¢Ö¬·¾ÉÏÇå-Ðļ¡¡¢¡¢Ö¬·¾ÉÏÇå-½»¸Ð-Ðļ¡µÈÈýÖÖ²î±ðµÄ¹²×÷Óýϵͳ£¬¼ì²âÕâЩ¹²×÷ÓýÌõ¼þÏÂÐļ¡Ï¸°ûµÄ¸Æ˲±äÇéÐΣ¨¸Æ˲±äÊÇÓÉÐ˷ܼ¤¶¯ËùÓÕ·¢µÄÐļ¡Ï¸°û°ûÖÊÄÚ˲ʱÐÔ¸ÆÔö¸ß£¬ÊÇÐļ¡Ï¸°ûÖ÷ÒªµÄCa2+´¦ÀíÌØÕ÷£¬ÓëÐļ¡Ï¸°ûËõ¶Ì½ÚÂÉÇ×½üÏà¹Ø£©¡£¡ £¡£¡£Ð§¹û·¢Ã÷£¬Ðļ¡Ï¸°ûÓëÖ¬·¾ÉÏÇå»ò½»¸ÐÉñ¾­¹²×÷Óýʱ£¬Ðļ¡Ï¸°û±¬·¢¸Æ˲Òì³£µÄƵÂʽÏδ´¦ÀíµÄÐļ¡Ï¸°ûÎÞÏÔÖø¸Ä±ä£»È»¶ø£¬×÷ÓýϵͳÖÐͬʱ¼ÓÈëÖ¬·¾ÉÏÇåºÍ½»¸ÐÉñ¾­Ê±£¨¼´ÈýÕß¹²×÷Óý×飩£¬Ðļ¡Ï¸°û¸Æ˲±äÒì³£µÄ±¬·¢ÆµÂÊÏÔןßÓÚÆäËûÁ½Á½¹²×÷Óýϵͳ¡£¡ £¡£¡£Í¬Ê±£¬Î¢µç¼«ÕóÁмì²âЧ¹ûÏÔʾÈýÕß¹²×÷Óý×éÖУ¬Ðļ¡Ï¸°ûµç´«µ¼Ä£Ê½¸Ä±ä£¬±¬·¢ÀàËÆÐÄÂÉʧ³£Ñù¸Ä±ä¡£¡ £¡£¡£½øÒ»²½Ñо¿·¢Ã÷£¬Ö¬·¾Ï¸°ûÒò×Óleptinͨ¹ýleptinÊÜÌ弤»îSOCS3½ø¶øÒÖÖÆJAK2/SATA3ͨ·£¬´Ùʹ½»¸ÐÉñ¾­Éø͸¸ü¸ßˮƽµÄÉñ¾­µÝÖÊ¡£¡ £¡£¡£Í¬Ê±£¬¸ÃÑо¿·¢Ã÷£¬½»¸ÐÉñ¾­Ö÷ÒªÒÀÀµÓÚÉñ¾­ëÄY£¨NPY£©ÓëY1RµÄÏ໥×÷Óõ¼ÖÂÐļ¡Ï¸°ûµÄ½ÚÂÉÒì³£¡£¡ £¡£¡£ ÁÙ´²Êý¾Ý½øÒ»²½Åú×¢£¬ÐÄÍâĤ֬·¾ÔöºñµÄ·¿²ü»¼ÕßÆä¹Ú×´ñ¼ÑªÇåÖÐNPYµÄº¬Á¿Ô¶¸ßÓÚ·ÇÐÄÍâĤ֬·¾ÔöºñµÄ·¿²ü»¼Õߣ¬ÇÒÓë·¿²üµÄÑÏÖس̶ȳÊÕýÏà¹Ø¡£¡ £¡£¡£

×îºó£¬Ñо¿Ö°Ô±Ì½ÌÖÁËNPYÓÕ·¢Ðļ¡Ï¸°û½ÚÂÉÒì³£µÄ·Ö×Ó»úÖÆ£¬·¢Ã÷ÈýÕß¹²×÷Óý×éµÄÐļ¡Ï¸°ûÄÚ¸Æ/¸Æµ÷ÂÑ°×ÒÀÀµÐÔÂÑ°×¼¤Ã¸ II £¨CaMK¢ò£©¡¢¡¢ÄƸƽ»Á÷Ì壨NCX£©»îÐÔÉý¸ß£¬µ¼ÖÂÑÓ³Ùºó³ý¼«£¨DADs£©ÔöÌí£¬ÒýÆðÐļ¡Ï¸°û¸Æ˲±äÒì³££¬±¬·¢ÐÄÂÉʧ³£Ñù¸Ä±ä¡£¡ £¡£¡£¶øY1ÊÜÌåÒÖÖƼÁ¡¢¡¢CaMK¢òÒÖÖƼÁ¡¢¡¢NCXÒÖÖƼÁ¿ÉÒÔÓÐÓÃ×è¶ÏNPYµÄÖÂÐÄÂÉʧ³£×÷Óᣡ £¡£¡£

048F83850B7E9DA2B57F42D7421_B455315B_391EE

×ÛÉÏËùÊö£¬¸ÃÑо¿Í¨¹ý½¨Éè¹²×÷ÓýÄ£×ÓÄ£ÄâÐÄÔà×é֯΢ÇéÐΣ¬ÉîÈë̽ÌÖÐÄÍâĤ֬·¾ÏàÌåÌùÂÉʧ³£µÄ±¬·¢ÆøÀí¡£¡ £¡£¡£Ñо¿Ð§¹ûÅú×¢£¬Ö¬·¾Òò×Óleptin¼¤»î½»¸ÐÉñ¾­£¬´ÙʹÆäÉø͸¸ü¸ßˮƽµÄNPY¡£¡ £¡£¡£NPYͨ¹ýY1RÊÜÌåÒýÆðÐļ¡Ï¸°ûÄÚ¸ÆÎÈ̬Òì³££¬ÓÕ·¢Ðļ¡Ï¸°ûÐÄÂÉʧ³£Ñù¸Ä±ä¡£¡ £¡£¡£ÒÖÖÆY1RºÍÏÂÓθÆÐźÅÏà¹ØÂѰ׿ÉÒÔÓÐÓÃ×è¶ÏNPYµÄ×÷Óᣡ £¡£¡£¸ÃÑо¿Ö¤ÊµÖ¬·¾-Éñ¾­Öá¼ÓÈëÐÄÂÉʧ³£µÄ±¬·¢£¬ÎªÐÄÂÉʧ³£µÄÖÎÁÆÌṩÁËDZÔÚµÄаеã¡£¡ £¡£¡£Í¬Ê±£¬Ò²ÎªÑо¿EAT/ ½»¸ÐÉñ¾­ÏµÍ³Ïà¹Ø¼²²¡µÄ·¢²¡»úÖÆ¡¢¡¢Ì½Ë÷Ô¤·À/ÖÎÁÆÕ½ÂÔÌṩÓÐÁ¦µÄ¹¤¾ß¡£¡ £¡£¡£

ngµç×ÓÓÎÏ·ÖÐɽҽѧԺµÄÀîΰǿ½ÌÊÚ¡¢¡¢ÏîÅô½ÌÊÚ£¬ngµç×ÓÓÎÏ·Á¥ÊôµÚÈýÒ½ÔºÖì½àÃ÷½ÌÊں͸ßÖÝÊÐÈËÃñÒ½ÔºÖìÐãÁú½ÌÊÚΪÅäºÏͨѶ×÷Õߣ»ÍŶӳÉÔ±·¶Óñ±¦²©Ê¿¡¢¡¢»Æɺɺ²©Ê¿ºÍÀîËÕ»ª¸±Ö÷ÈÎҽʦΪÅäºÏµÚÒ»×÷Õß¡£¡ £¡£¡£

ÂÛÎÄÁ´½Ó£º£º£ºhttps://doi.org/10.1016/j.xcrm.2024.101559

¡¾ÍøÕ¾µØͼ¡¿