ngµç×ÓÓÎÏ·ÐÂÎÅÍøÑ¶£¨Í¨Ñ¶Ô±¶¡Ó¨£©¿ËÈÕ£¬£¬£¬ngµç×ÓÓÎÏ·¹«¹²ÎÀÉúѧԺ·ëµ¤½ÌÊÚ¿ÎÌâ×éÔÚÓªÑøÑ§ÁìÓò¶¥¼¶ÆÚ¿¯¡¶The American Journal of Clinical Nutrition¡·ÉϽÒÏþÌâΪ¡°Curcumin supplementation alleviates hepatic fat content associated with modulation of gut microbiota-dependent bile acid metabolism in patients with non-alcoholic simple fatty liver disease: a randomized controlled trial¡±µÄÔ´´ÐÔÑо¿ÂÛÎÄ¡£»£»ùÓÚÒ»ÏîËæ»ú±ÈÕÕÊÔÑ飨RCT£©£¬£¬£¬¸ÃÑо¿Õ¹ÏÖÁËÉÅʳÔö²¹½ª»ÆËØïÔ̷Ǿƾ«ÐÔ´¿´âÐÔÖ¬·¾¸Î»¼Õ߸ÎÔàÖ¬·¾º¬Á¿ÓëÆä¸ÄÉÆ³¦µÀ¾úȺ½éµ¼µÄµ¨ÖËá´úлÓйء£
·Ç¾Æ¾«ÐÔÖ¬·¾¸Î£¨NAFLD£©ÊÇ×î³£¼ûµÄÂýÐԸβ¡Ö®Ò»£¬£¬£¬ÆäÌØÕ÷ÊǸÎÔàÖ¬·¾Ðî»ý¡£ÓÉÓÚÈËÃÇÉúÑÄ·½Ê½ºÍÒûʳģʽµÄ¸Ä±ä£¬£¬£¬NAFLD ·¢²¡ÂÊÖðÄêÔö¸ß£¬£¬£¬Ô¼Ó°ÏìÈ«Çò20-30% ³ÉÄêÈË£¬£¬£¬ÆäÖзǾƾ«ÐÔ´¿´âÐÔÖ¬·¾¸Î£¨NASFL£©ÊÇNAFLDµÄÔçÆÚ½×¶ÎÇÒ¿ÉÒÔÄæ×ª£¬£¬£¬Ô¼Õ¼NAFLD µÄ80%¡£Òò´Ë£¬£¬£¬ÔÚNASFL½×¶Î¸øÓèʵʱ¸ÉÔ¤ÓÈΪÖ÷Òª¡£½ª»ÆËØÊÇÒ»ÖÖ´ÓÉÅʳÏãÁϺÍʳÓÃÉ«ËØ½ª»ÆÖÐÌáÈ¡µÄ¶à·ÓÀàÖ²ÎﻯѧÎ£¬£¬ÓÉÓÚÆä¿¹Ñס¢¡¢¿¹Ñõ»¯¡¢¡¢½µÖ¬ºÍ½µÑªÌÇÌØÕ÷£¬£¬£¬ÔÚ·ÀÖδúлÐÔ¼²²¡·½Ãæ¾ßÓÐÖ÷Òª¼ÛÖµ¡£±¾¿ÎÌâ×éǰÆÚµÄÒ»ÐòÁж¯ÎïʵÑéÑо¿Ð§¹ûÏÔʾÉÅʳÌí¼Ó½ª»ÆËØ¿ÉÒÔ½µµÍ¸ßÖ¬¸ßµ¨¹Ì´¼ÒûʳιËDzÖÊóѪҺ¸ÊÓÍÈýõ¥ºÍµ¨¹Ì´¼Ë®Æ½£¬£¬£¬ïÔ̸ÎÔàÖ¬·¾Ðî»ýºÍ¸ÄÉÆ³¦µÀ¾úȺ¡£È»¶ø£¬£¬£¬½ª»ÆËضÔNASFL»¼Õ߸ÎÔàÖ¬·¾º¬Á¿ºÍ³¦µÀ¾úȺÒÔ¼°Æäµ¨ÖËá´úлµÄÓ°ÏìÉв»ÇåÎú£¬£¬£¬ÈÔÐ迪չ¸ü¾ß˵·þÁ¦µÄÁÙ´²ÊÔÑé¡£
±¾Ñо¿½ÓÄÉËæ»ú±ÈÕÕÊÔÑ飬£¬£¬»ùÓÚFibroTouchµÄÊÜ¿ØË¥¼õ²ÎÊý£¨CAP£©ºÍ¸ÎÔàÓ²¶ÈÕÉÁ¿£¨LSM£©»®·ÖÆÀ¹À¸ÎÔàÖ¬·¾º¬Á¿ºÍ¸ÎÔàÓ²¶È¡£Ð§¹û·¢Ã÷£º£ºÓëο½å¼Á×éÏà±È£¬£¬£¬½ª»ÆËظÉÔ¤24ÖܺóÏÔÖø½µµÍNASFL»¼Õ߸ÎÔàÖ¬·¾º¬Á¿¡¢¡¢ÌåÖØºÍÌåÖÊÖ¸ÊýÒÔ¼°ÑªÇåÓÎÀëÖ¬·¾Ëá¡¢¡¢¸ÊÓÍÈýõ¥¡¢¡¢¿Õ¸¹ÑªÌÇ¡¢¡¢ÌÇ»¯ÑªºìÂѰ׺ÍÒȵºËØË®Æ½£¬£¬£¬¶øÉý¸ßHDL-Cˮƽ¡£³¦µÀ¾úȺÆÊÎöЧ¹ûÅú×¢½ª»ÆËظÉÔ¤ÏÔÖø½µµÍºñ±Ú¾úÃÅÓëÄâ¸Ë¾úÃŵıÈÖµ£¬£¬£¬²¢ÏÔÖøÔöÌíÓ뵨ÖËá´úлÇ×½üÏà¹ØµÄÄâ¸Ë¾úÊôÏà¶ÔƷò¡£ÑªÇ嵨ÖËá°ÐÏò´úл×éѧÆÊÎö·¢Ã÷½ª»ÆËظÉÔ¤24Öܺ󣬣¬£¬GÂѰ׿ÁªÊÜÌå5£¨TGR5£©×îÓÐÓõ碌î¼ÁÍÑÑõµ¨ËᣨDCA£©ÑªÇåˮƽÏÔÖøÉý¸ß¡£±ðµÄ£¬£¬£¬½ª»ÆËظÉÔ¤ÏÔ×ÅÔöÌíÍâÖÜѪµ¥ºËϸ°ûTGR5 mRNA±í´ïÁ¿ºÍѪÇåÒȸßѪÌÇËØÑùëÄ-1£¨GLP-1£©Ë®Æ½¡£

ͼ1. ½ª»ÆËظÄÉÆ·Ç¾Æ¾«ÐÔ´¿´âÐÔÖ¬·¾¸ÎµÄ×÷ÓûúÀíʾÒâͼ
Ñо¿Ð§¹û²»µ«Õ¹ÏÖÁ˽ª»ÆËظÉÔ¤¿ÉÒÔÓÐÓõؽµµÍNASFL»¼Õ߸ÎÔàÖ¬·¾º¬Á¿¡¢¡¢ÌåÖØ¡¢¡¢ÌåÖÊÖ¸ÊýºÍѪÌÇˮƽ£¬£¬£¬»¹·¢Ã÷½ª»ÆËضÔNASFL¸ÄÉÆ×÷ÓÃÓëÆäµ÷Àí³¦µÀ¾úȺ½éµ¼µÄµ¨ÖËá´úлºÍÔö½øµ¨ÖËáÊÜÌåTGR5¼¤»îÓйء£±¾Ñо¿½«ÎªÖ²ÎﻯѧÎェ»ÆËØ·ÀÖÎNASFLµÄÁÙ´²Ó¦ÓõÓÚ¨»ù´¡¡£
ngµç×ÓÓÎÏ·¹«¹²ÎÀÉúѧԺ˶ʿÉúºØÓÐÃ÷ºÍ³ÂÏþ±ùÒÔ¼°·ðɽÊÐÄϺ£ÇøÈËÃñÒ½ÔºÖ¬·¾¸ÎÃÅÕïÀîÓÀ´ºÖ÷ÈÎҽʦΪ±¾ÎÄÅäºÏµÚÒ»×÷Õߣ¬£¬£¬·ëµ¤½ÌÊÚΪ±¾ÎÄͨѶ×÷Õߣ¬£¬£¬ngµç×ÓÓÎÏ·¹«¹²ÎÀÉúѧԺΪÂÛÎĵÚÒ»ÊðÃûµ¥Î»¡£±¾Ñо¿Êܵ½¹ú¼Ò×ÔÈ»¿ÆÑ§»ù½ð¡¢¡¢¹ã¶«Ê¡×ÔÈ»¿ÆÑ§»ù½ðµÈÏîÄ¿µÄÖ§³Ö¡£
ÂÛÎÄÁ´½Ó£º£ºhttps://doi.org/10.1016/j.ajcnut.2024.05.017