´´ÉËÐÔ¼¹ËèËðÉ˿ɵ¼Ö¼¹ËèÉñ¾ÔªµÄ´ó×ÚéæÃü£¬£¬£¬ÑÏÖØµÄ»áʹ»¼ÕßÍêÈ«ËðʧÔ˶¯ºÍ¸ÐÊܹ¦Ð§£¬£¬£¬Ôì³ÉÊÜËð½Ú¶ÎÒÔÏÂÍêȫ̱»¾¡£¡£Éñ¾¸Éϸ°ûÒÆÖ²Ò»Ö±±»ÒÔΪÊÇÒ»ÖÖ¿ÉÐеļ¹ËèËðÉËϸ°ûÁÆ·¨£¬£¬£¬¿ÉÓÐÓÃÔö²¹ÊÜËðéæÃüµÄÉñ¾Ôª²¢ÖØÐÞÉñ¾ÍøÂç¡£¡£È»¶ø£¬£¬£¬ÓÉÓÚÒÆÖ²¸Éϸ°û¼«µÍµÄ´æ»îÂʺÍÌåÄÚ·Ö»¯Æ«Ïò²»ÊÜ¿ØÖƵÈÍ»³öÎÊÌ⣬£¬£¬Ö±½Ó½«Î´³ÉÊìµÄÉñ¾¸Éϸ°û×¢Éäµ½ËðÉ˲¿Î»ºó£¬£¬£¬¼¹ËèÉñ¾ÔÙÉúºÍ¹¦Ð§»Ö¸´Ð§¹û²¢²»²ÇÏë¡£¡£
Õë¶Ô¼¹ËèËðÉËϸ°ûÒÆÖ²ÁÆ·¨ÖеÄÍ´µãÎÊÌ⣬£¬£¬ÖÊÁÏ¿ÆÑ§Ó빤³ÌѧԺ°×Ó¨¸±½ÌÊÚÍŶÓÌá³öÁËÒ»ÖÖʹÓÃ×ÔÈ»¼¹Ëè×é֯ȪԴµÄÍÑϸ°û»ùÖÊ΢Äý½º×÷ΪÉñ¾¸É/×æÏ¸°û£¨Neural stem/progenitor cells, NSPCs£©ÒÆÖ²ÔØÌ壬£¬£¬Í¨¹ýÌåÍâÔ¤·Ö»¯ºÍ΢´´ÔλעÉ䷽ʽ¶ÔÑÏÖØµÄ¼¹Ëè´ìÉ˼²²¡Ä£×Ó¾ÙÐÐϸ°ûÖÎÁÆ¡£¡£ÓÉÓÚ¸ÃÍÑϸ°û»ùÖÊ΢Äý½º¾ßÓм¹Ëè×éÖ¯ÌØÒìÐÔµÄÉúÎï»îÐÔ£¬£¬£¬¿ÉÔÚÌåÍâÔö½øNSPCsÏòÉñ¾Ôª·Ö»¯£¬£¬£¬²¢ÔÚÒÆÖ²ºóͨ¹ý¸ÄÉÆ¼¹ËèËðÉË΢ÇéÐÎÕÙļÄÚÔ´ÐÔ¸Éϸ°û£¬£¬£¬ÊµÏÖϸ°ûÒÆÖ²ÁÆ·¨ÓëÄÚÔ´ÐÔÐÞ¸´ÔÙÉúµÄÐͬ×÷Óᣡ£ÕâÖÖÔλϸ°ûÖÎÁÆÒªÁìÀÖ³ÉÌá¸ßÁËÒÆÖ²NSPCsÓÃÓÚ¼¹ËèËðÉËÖÎÁƵÄÊõºóЧ¹û£¬£¬£¬¾ßÓм«Ç¿µÄÁÙ´²×ª»¯Ç±Á¦¡£¡£

ͼ1. NSPC@DSCM-MGsµÄÖÆ±¸Àú³Ì
Ê×ÏÈ£¬£¬£¬±¾Ñо¿Ê¹ÓÃ×ÔÖ÷´î½¨µÄ΢Á÷¿ØÏµÍ³½«NSPCs·â×°ÔÚ¼¹ËèȪԴÍÑϸ°û»ùÖÊ΢Äý½º(DSCM-MGs)ÖУ¬£¬£¬ÀֳɻñµÃÁ˸ºÔØNSPCsµÄÍÑϸ°û»ùÖÊ΢Äý½º(NSPC@DSCM-MGs)£¬£¬£¬²¢ÔÚÌåÍâ¶ÔÆä¾ÙÐÐÉñ¾ÔªÏò·Ö»¯ÓÕµ¼¡£¡£Ð§¹û֤ʵ£¬£¬£¬ NSPC@DSCM-MGs ÖÐÈýά·õÓýµÄNSPCsÔÚÆßÌìÄڴ󲿷ÖÏòÉñ¾Ôª¶ø·ÇÐÇÐνºÖÊϸ°û·Ö»¯¡£¡£¸ÃЧ¹ûͬʱÅú×¢»ùÓÚ΢Äý½ºµÄÈýά×÷Óýϵͳ£¬£¬£¬Ïà±ÈÓڹŰåµÄ´ó¿éË®Äý½ºÈýά×÷Óý£¬£¬£¬¿ÉÒÔÔ½·¢ÏÔ×ŵØÌá¸ßNSPCsÏòÉñ¾Ôª·Ö»¯µÄЧÂÊ¡£¡£

ͼ2. NSPC@DSCM-MGsÔÚÌåÍâÔ¤·õÓý¿ÉÔö½øNSPCsÏòÉñ¾Ôª·Ö»¯
½«¾ÓÕµ¼·Ö»¯Ô¤·õÓýNSPC@DSCM-MGs±¬·¢µÄ3DÉñ¾Çò×¢Éäµ½ÑÏÖØ´ìÉ˵ĴóÊó¼¹ËèÄ£×ÓÖУ¬£¬£¬·¢Ã÷ÍÑϸ°û»ùÖÊ΢Äý½º¿ÉÓÐÓñ£»¤ÒÆÖ²Ï¸°û£¬£¬£¬ÃâÊܼôÇÐËðÉ˺Ͳ¡±ä²¿Î»Ñ×֢΢ÇéÐεÄËðÉË£¬£¬£¬ÏÔÖøÌá¸ßÁËÍâÔ´ÐÔϸ°ûµÄ´æ»îÂÊ¡£¡£±ðµÄ£¬£¬£¬NSPC@DSCM-MGsÔÚÌåÄÚÌá¸ßÁËÒÆÖ²µÄÒÔ¼°ÕÙļµÄÄÚÔ´ÐÔNSPCsÏòÉñ¾Ôª·Ö»¯µÄЧÂÊ£¬£¬£¬ÓÐÓÃÔö²¹Á˼¹ËèËðÉ˺óËðʧµÄÉñ¾ÔªÊýÄ¿£¬£¬£¬ÒÖÖÆÁ˽ºÖÊñ£ºÛµÄÐγɡ£¡£±ðµÄ£¬£¬£¬´ó×Ú´æ»îµÄÔ¤·Ö»¯NSPC@DSCM-MGsÆð¾¢µ÷ÀíËðÉ˲¿Î»Î¢ÇéÐΣ¬£¬£¬Ôö½øÄÚÔ´ÐÔϸ°ûÕÙļ¡¢ÖáÍ»ÔÙÉúºÍÉñ¾ÍøÂçÖØÐÞ£¬£¬£¬²¢×ÊÖúά³Ö¼¹Ëè×éÖ¯½á¹¹µÄÍêÕûÐÔ£¬£¬£¬Ôö½øÁËÑÏÖØ¼¹Ëè´ìÉË´óÊóµÄÔ˶¯¹¦Ð§»Ö¸´¡£¡£

ͼ3. ÒÆÖ²µÄNSPC@DSCM-MGsÔÚÌåÄÚÔö½øÖáÍ»ÔÙÉúºÍÉñ¾ÍøÂçÖØÐÞ
×ÛÉÏËùÊö£¬£¬£¬ÕâÖÖ»ùÓÚÍÑϸ°û»ùÖÊ΢Äý½ºÔØÌå¼°Ô¤·õÓýÊÖÒÕµÄÐÂÐ͸Éϸ°ûÒÆÖ²Õ½ÂÔ£¬£¬£¬ÔÚϸ°û±£»¤ºÍϸ°ûÔËÆøµ÷¿Ø·½ÃæÏÔʾ³öÆæÒìµÄÓÅÊÆ£¬£¬£¬Í¨¹ýÄÚÔ´ÐÔºÍÍâÔ´ÐÔϸ°ûµÄÐͬ×÷ÓÃÓÐÓÃÔö½øÊÜËð¼¹ËèµÄÔÙÉúÐÞ¸´¡£¡£¸ÃÒªÁìÔÚ×éÖ¯¹¤³ÌºÍÔÙÉúҽѧÁìÓòµÄÁÙ´²Ó¦ÓÃÖоßÓм«´óÔ¶¾°£¬£¬£¬²¢ÇÒÓÐÏ£ÍûÀ©Õ¹Ó¦ÓÃÓÚÆäËû¼²²¡µÄÖÎÁÆÖС£¡£
¸ÃÊÂÇéÓÚ2024Äê6ÔÂ20ÈÕÒÔ¡°Transplantation of Pre-Differentiated 3D Neural Spheroids in Decellularized Extracellular Matrix Microgels Promotes Neuronal Network Reconstruction and Functional Recovery after Severe Spinal Cord Contusion¡±ÎªÌâÔÚÏß½ÒÏþÓÚ¹ú¼Ê×ÅÃûѧÊõÆÚ¿¯Advanced Functional MaterialsÉÏ£¨DOI:10.1002/adfm.202407097£©¡£¡£ÖÊÁÏ¿ÆÑ§Ó빤³ÌѧԺ21¼¶Ë¶Ê¿Ñо¿ÉúÕÅ¿ÉöΣ¨ÅÅÃûµÚÒ»£©ºÍ²©Ê¿ºóÈÄ×ÓÁúΪ¸ÃÂÛÎÄÅäºÏµÚÒ»×÷Õߣ¬£¬£¬°×Ó¨¸±½ÌÊÚΪΨһͨѶ×÷Õߣ¬£¬£¬ÖÊÁÏ¿ÆÑ§Ó빤³ÌѧԺΪÂÛÎĵÚÒ»µ¥Î»¡£¡£¸ÃÑо¿ÊÂÇéÊܵ½¹ú¼Ò×ÔÈ»¿ÆÑ§»ù½ð¡¢¹ã¶«Ê¡»ù´¡ÓëÓ¦Óûù´¡Ñо¿»ù½ðµÈÏîÄ¿µÄ´óÁ¦Ö§³Ö¡£¡£
Á´½Ó£ºhttps://doi.org/10.1002/adfm.202407097