ngµç×ÓÓÎÏ·ÐÂÎÅÍøѶ£¨Í¨Ñ¶Ô±ÌÆÑÞÀö£©¾§×´ÌåÊÇÑÛÄÚ͸Ã÷µÄ˫͹͸¾µ×´×éÖ¯£¬£¬¾ßÓн«¹âÏß¾Û½¹ÔÚÊÓÍøĤµÄ¹¦Ð§¡£¾§×´Ìå»ì×Ǽ´°×ÄÚÕÏ£¬£¬ÊÇÌìÏÂÊ×λÖÂäÔÒò¡£ÏÖÔÚ³£ÓüÙÌ壨È˹¤¾§×´Ì壩¾ÙÐÐÊÖÊõÌæ»»ÖÎÁÆ£¬£¬µ«Ò½ÁƺÍÉç»á¾¼Ã±¾Ç®ÖØ´ó¡£ÈÃÈËÌ徧״ÌåÖÕÉí¼á³Ö͸Ã÷£¬£¬ÉõÖÁÔçÆÚÄæת»ì×Ç£¬£¬ÊÇ·ÀÖΰ×ÄÚÕÏ×îÀíÏëµÄÒªÁ죬£¬Ò²ÊÇÈËÀàµÄ²»Ð¸×·Çó¡£¾§×´ÌåÉÏƤϸ°ûÊǾ§×´Ìå½¹µãϸ°û£¬£¬¶ÔËü¾ÙÐиÉÔ¤ºÍµ÷¿Ø¿ÉÄÜÊÇʵÏÖÕâһĿµÄµÄÓÐÓÃ;¾¶£¬£¬µ«¼ÈÍù¶ÔËüµÄÉúÎïѧÌØÕ÷ȱ·¦ÖÜÈ«µÄÊìϤºÍʹÓá£ngµç×ÓÓÎÏ·ÖÐɽÑÛ¿ÆÖÐÐÄÁõÞÈÖ¾½ÌÊÚ»ùÓÚ±¾ÍŶÓÔÚ´ËÁìÓòµÄºã¾ÃÊÂÇ飬£¬´ÓÈ«ÉúÃüÖÜÆڵĽǶȣ¬£¬·¢Ã÷²¢ÐðÊö¾§×´ÌåÉÏƤϸ°ûÔÚ¾§×´ÌåÅßÌ¥·¢Óý¡¢¡¢¡¢Í¸Ã÷ÐÔά³ÖÓë´´ÉËÐÞ¸´²î±ðÀú³ÌÖеÄÖ÷Òª×÷Ó㬣¬Îª×ÔÌåϸ°û½éµ¼µÄ×éÖ¯¹¦Ð§Î¬³ÖºÍÐÞ¸´ÁÆ·¨ÌṩÀíÂÛÒÀ¾Ý£¬£¬Ç㸲ÁË°×ÄÚÕÏÁÙ´²·ÀÖεĹŰåÀíÄ£¬Îª¸ÃÁìÓòÑо¿Ö¸Ã÷ÎúδÀ´Æ«Ïò¡£ÎÄÕÂ2022Äê8ÔÂ31ÈÕÒÔ¡°The lens epithelium as a major determinant in the development, maintenance, and regeneration of the crystalline lens¡±ÎªÌâÔÚÑÛ¿Æ×î¾ßÓ°ÏìÁ¦ÆÚ¿¯Progress in Retinal and Eye ResearchÔÚÏß½ÒÏþ¡£
ÁõÞÈÖ¾½ÌÊÚÍŶӻØíøÁ˾§×´ÌåÉÏƤϸ°ûÔÚ¾§×´ÌåÉúÃüÖÜÆÚÖгÊÏÖµÄÉñÆæÀú³Ì£¬£¬ÐðÊöÁ˾§×´ÌåÉÏƤϸ°ûÔÚÅßÌ¥·¢Óý¡¢¡¢¡¢ÎÈ̬ά³ÖºÍÊõºóÔÙÉúÈý¸ö½×¶ÎÊ©Õ¹µÄ¾öÒéÐÔ×÷Óá£
ÅßÌ¥ÆÚ£¬£¬ÈªÔ´ÓÚ±íƤÍâÅß²ãµÄµ¥²ãϸ°ûÐγɾ§×´ÌåÅÝ£¬£¬²î±ð²¿Î»Êܲî±ðµ÷¿ØÐźŵÄÓ°Ï죬£¬Ðγɾ§×´ÌåÈýά½á¹¹µÄ²î±ð²¿Î»¡ £ºó²¿ºÍ³àµÀ²¿µÄ¾§×´ÌåÉÏƤϸ°ûÂÄÀúÁËϸ°ûÖÜÆÚµÄÍ˳ö¡¢¡¢¡¢¾§ÌåÂѰ׵ıí´ï¡¢¡¢¡¢°ûÌåÀ³¤¡¢¡¢¡¢ÍÑϸ°ûÆ÷¼°È¥ºËµÈÒªº¦»·½Ú»®·ÖÐγɳõ¼¶ºÍ´Î¼¶¾§×´ÌåÏËά£»£»£»Ç°²¿¾§×´ÌåÉÏƤϸ°û·Ö»¯À©ÔöÐγÉÉÏƤ²ã£¬£¬ÆäÖв¿·Öϸ°û±£´æÁË·Ö»¯ÎªÏËάϸ°ûµÄÄÜÁ¦¡£ÕâЩ»·½ÚÊܵ½»ùÒò»òÇéÐÎÒòËصȵÄÓ°Ï죬£¬¶¼½«µ¼Ö¾§×´Ìå·¢ÓýÒì³£¡£Ê¹ÓÃÈ«»ùÒò×é»ùÒò·ÖÐͺÍÈ«»ùÒò×é¹ØÁªÑо¿ (GWAS) µÈ¾ÙÐлùÒòɸ²é£¬£¬Ê¹ÓÃXÉäÏß¾§ÌåѧºÍÀ䶳µç×ÓÏÔ΢¾µÆÊÎöRNAºÍÂÑ°×Öʽṹ£¬£¬ÓÐÖúÓÚÕ¹ÏÖÒÅ´«È±ÏÝÔõÑùË𺦾§×´ÌåÉÏƤϸ°ûÄÚµÄÂÑ°×Öʹ¦Ð§£¬£¬ÎªÕ¹ÏÖ¾§×´Ìå·¢ÓýÒì³£µÄ·Ö×Ó»úÖÆÌṩеÄÊӽǡ£
¾§×´Ìå³ÉÊìºó£¬£¬Ç°ÄÒϺͳàµÀ²¿µÄ¾§×´ÌåÉÏƤϸ°ûͨ¹ýÎïÖʺϳÉÓë½»Á÷¡¢¡¢¡¢»ºÂýµÄÔöÖ³·Ö»¯Î¬³Ö¾§×´ÌåÎÈ̬¡£²î±ðÇøÓòµÄ¾§×´ÌåÉÏƤϸ°û¡¢¡¢¡¢¾§×´ÌåÏËάϸ°ûµÄϸ°ûĤ¼ä±£´æµçλ²î£¬£¬Ðγɾ§×´Ìå΢ѻ·£¬£¬ÔËÊäÄÜÁ¿¼°ÑõÆøµÈÎïÖÊ£¬£¬ËüµÄÒì³£½«ÒýÆð°×ÄÚÕÏ¡£µ¨¹Ì´¼µÄºÏ³ÉÕÏ°ÒýÆð¾§×´Ìå»ì×Ç¡£ÑòëçÞ´¼Êǵ¨¹Ì´¼ºÏ³ÉµÄÖ÷ÒªÖÐÐIJúÆ·£¬£¬»¹¿ÉÒÔÎȹ̷Ö×ÓÅóÙ¡¢¡¢¡¢ÔöÇ¿ÂÑ°×øÌå»îÐÔ£¬£¬ÒÔ¸ÄÉƾ§×´ÌåÂÑ°×ÏûÈڶȣ¬£¬Î¬³Ö»ò»Ö¸´¾§×´Ìå͸Ã÷ÐÔ¡£
¾§×´ÌåÊÖÊõºó£¬£¬ÎÒÃÇ¿ÉÒÔ¼ÝÔ¦¾§×´ÌåÉÏƤϸ°ûÔöÖ³·Ö»¯µÄÉúÎïѧÌØÕ÷ÓÃÓÚÁÙ´²ÖÎÁÆ¡£¾§×´ÌåÉÏƤϸ°ûµÄ²»ÍêÈ«·Ö»¯ÓëÏËά»¯±¬·¢»ì×ǵÄ×éÖ¯£¬£¬ÍêÈ«·Ö»¯¡¢¡¢¡¢ÓÐÐòÅÅÁб¬·¢Í¸Ã÷µÄ¾§×´ÌåÏËά×éÖ¯¡£ÔÚÈ˹¤¾§×´ÌåÑÛÄÚ£¬£¬Ö²ÈëµÄ¼ÙÌåÊ©Õ¹¹âѧ×÷Ó㬣¬¾§×´ÌåÉÏƤϸ°ûµÄÔöÖ³»áÓ°ÏìÈ˹¤¾§×´ÌåµÄ¹¦Ð§¡£¿£¿£¿ÉÒÔ½ÓÄÉÈ˹¤¾§×´ÌåµÄÖ±½Ç·½±ßÆÁÕÏЧӦºÍºóÄÒÒºÁ÷Å×¹âÊÖÒյȣ¬£¬É¨³ý»òÒÖÖƾ§×´ÌåÉÏƤϸ°û¡£ÔÚÓ¤Ó׶ù£¬£¬¿ÉÒÔˢа×ÄÚÕÏÕª³ýʱµÄÇ°¡¢¡¢¡¢ºó˺ÄÒ¿Ú´óС£¬£¬Ôö½øÎÞ¾§×´ÌåÑÛÖܱ߲¿Soemmerring »·µÄÐγɣ¬£¬ÀûÓÚIIÆÚÄÒ´üÄÚÖ²ÈëÈ˹¤¾§×´Ì壻£»£»»òÕßͨ¹ý¾§×´Ì峬΢´´ÊÖÊõ£¬£¬ÒƳý»ì×Ǿ§×´ÌåÄÚÈÝÎï¶ø±£´æ¾§×´ÌåÉÏƤϸ°û£¬£¬¿ÉÔλÔÙÉú³öÓÐÇü¹âÁ¦µÄ͸Ã÷¾§×´Ì壬£¬¸ÄÉÆÓ¤Ó׶ù°×ÄÚÕϵÄÔ¤ºó¡£
ʵÏÖÈËÀྦྷ״ÌåÖÕÉí͸Ã÷ÊÇ°×ÄÚÕÏ·ÀÖεÄ×îÖÕÄ¿µÄ£¬£¬Ñо¿ºÍʹÓþ§×´ÌåÉÏƤϸ°ûµÄÉúÎïѧÌØÕ÷¿ÉÄÜÊÇʵÏÖÕâһĿµÄµÄÓÐÓÃ;¾¶¡£
¾§×´ÌåÉÏƤϸ°ûÔÚ·¢Óý¡¢¡¢¡¢Í¸Ã÷ÐÔά³ÖºÍÔÙÉúÐÞ¸´ÖеÄ×÷ÓÃ
ÂÛÎÄÁ´½Ó £ºhttps://authors.elsevier.com/a/1fgRa4pAsjh4fM
µØµã:¹ãÖÝÊÐиÛÎ÷·135ºÅ Óʱà:510275
µç»°: 020-84112828
ngµç×ÓÓÎÏ·°æȨËùÓÐ COPYRIGHT?1999-2022 , SUN YAT-SEN UNIVERSITY